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Source: GEO: Gene Expression Omnibus
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Total 1028 results found since Jan 2013.
GSE186225 CUT-tag analysis of T24 cells treated with a control scramble (scr) siRNA or a si-circSLC38A1
This study aims to investigate whether circSLC38A1 could affect the enrichment of downstream genes by the transcription factor ILF3.T24 cells were treated with a control scramble (scr) siRNA or a siRNA that specifically knock down the expression of circSLC38A1, 48h after ttansfection, cells were collected and treated for CUT-tag.CUT-tag-Seq analysis provided evidence of ILF3 enrichment of downstream genes changes between si-NC and si-circSLC38A1 T24 cells.
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE185523 RNASeq of human bronchial epithelial (HBE) cells with cGAS-siRNA transfected
Contributors : Zhangchu Jin ; Wenqi Diao ; Anyi Guo ; Shiyi Yang ; Yinling Han ; Yinfang Wu ; Yun Zhao ; Yanping Wu ; Jiaxin Shen ; Songmin Ying ; Wen Li ; Huhao Shen ; Zhihua Chen ; Fugui YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a newly discovered sensor that detects cytosolic DNA as a universal danger-associated molecular pattern (DAMP). Here, we used RNA-seq to analyze transcriptomic expression difference between control-siRNA and cGAS-siRNA cells to find out what genes involved in the r...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE135920 Reprogramming of root cells during nitrogen-fixing symbiosis entails dynamic polysome association of coding and non-coding RNAs
Contributors : Soledad Traubenik ; Mauricio Reynoso ; Karen Hobecker ; Marcos Lancia ; Maureen Hummel ; Benjamine Rosen ; Christhpher Town ; Julia Bailey-Serres ; Flavio A Blanco ; Maria E ZanettiSeries Type : Expression profiling by high throughput sequencingOrganism : Medicago truncatulaGMUCT 2.0 data were analyzed to globally identify 5 ’ ends differentially accumulated in SKI3 RNAi roots as compared with GUS RNAi, as well as those that change in abundance in response to rhizobiaSUPERKILLER3 (*SKI3),* a member of SKI complex that guides RNAs to the 3 to 5' exoribonuclease of the exosome complex. In the absence of a fu...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Medicago truncatula Source Type: research
GSE210922 FOXM1-mediated regulation of reactive oxygen species and radioresistance in oral squamous cell carcinoma cells
Contributors : Hisashi Takeshita ; Ryoji Yoshida ; Junki Inoue ; Mayumi Hirayama ; Toru Oyama ; Ryuta Kubo ; Keisuke Yamana ; Yuka Nagao ; Shunsuke Gohara ; Junki Sakata ; Masatoshi Hirayama ; Kenta Kawahara ; Nozomu Takahashi ; Akiyuki Hirosue ; Yoshikazu Kuwata ; Manabu Fukumoto ; Ryo Toya ; Ryuji Murakami ; Hideki NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRadioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) cell lines, generated by irradiating parental...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE206084 RNA-seq on primary human kidney epithelial cells with oleate treatment and PLIN2 knockdown
Contributors : Haikuo Li ; Benjamin D HumphreysSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we investigated the transcriptomic changes induced by oleic acid treatment on human Primary Renal Proximal Tubule Epithelial Cells (RPTECs) with RNA-seq. We also profiled cells with oleic acid treatment after PLIN2 gene knockdown with siRNA treatment.
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE156106 Macrophage-mediated abscopal effects of radiation therapy
Contributors : Yoko Nishiga ; Alexandros P Drainas ; Julien SageSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRadiation therapy is a mainstay of cancer treatment, with more than 50% of all cancer patients receiving radiation during the course of their disease. Tumor irradiation can activate both innate and adaptive immune responses, and these responses can be pro- or anti-tumor growth . These observations have led to the search for antitumor approaches combining radiotherapy and specific immunotherapies, most commonly strategies promoting the systemic activation of T cells. Thus far...
Source: GEO: Gene Expression Omnibus - September 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE213861 Ferroptosis of tumor-associated neutrophils is immunosuppressive and promotes tumor growth
Contributors : Gozde Kar ; Ayumi HashimotoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFerroptosis is a non-apoptotic form of regulated cell death triggered by the discoordination of regulatory redox mechanisms culminating in massive peroxidation of polyunsaturated phospholipids. The development of the concept of ferroptosis stemmed from an active search for alternatives to apoptosis in cancer cells. Ferroptosis inducers have shown remarkable effectiveness in killing tumor cells in vitro, yet with no obvious success in experimental animal models, with a notable exception of immune-...
Source: GEO: Gene Expression Omnibus - September 24, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE169129 VPRBP, a novel androgen receptor and OGT target is an essential mediator of cellular transformation in prostate cancer
In this study, we employed chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) to identify changes in p53 binding to the genome in VPRBP knockdown LNCaPs compared to scrambled siRNA transfected control cells. Stabilization of p53 was associated increased p53 recruitment to the chromatin.
Source: GEO: Gene Expression Omnibus - September 22, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE205371 Ferroptosis of tumor-associated neutrophils is immunosuppressive and promotes tumor growth
Contributors : Dmitry Gabrilovich ; Rina KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFerroptosis is a non-apoptotic form of regulated cell death triggered by the discoordination of regulatory redox mechanisms culminating in massive peroxidation of polyunsaturated phospholipids. The development of the concept of ferroptosis stemmed from an active search for alternatives to apoptosis in cancer cells. Ferroptosis inducers have shown remarkable effectiveness in killing tumor cells in vitro, yet with no obvious success in experimental animal models, with a notable exception of immun...
Source: GEO: Gene Expression Omnibus - September 19, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE212324 RNA-sequencing in for Low, high or high density+PTPRK-deleted HeLa cells
Contributors : Hyun A Sohn ; Young I Yeom ; Dong C LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDensity-dependent regulation of cell growth is presumed to be caused by cell-cell contact, but the underlying molecular mechanism is not yet clearly defined. Our goal is to identify receptor-type protein tyrosine phosphatase-kappa (PTPRK) is an important regulator of cell contact-dependent growth inhibition and to elucidate the related mechanism regulated by PTPRK with analyzing transcriptome-based datasets generated from different condition of cell density combined with manipulation ...
Source: GEO: Gene Expression Omnibus - September 2, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE183178 Identification of Wnt target genes associated with malignant phenotypes in CTNNB1-mutated NSCLC
Contributors : Noriaki Sunaga ; Luc GirardSeries Type : Expression profiling by arrayOrganism : Homo sapiensMicroarray analysis comparing the expression profiles of siRNA-mediated CTNNB1-silenced and CTNNB1-retained HCC15 cells harboring a homozygous CTNNB1 S45F mutation revealed that besides several known Wnt genes, LGR6 was significantly downregulated by CTNNB1 knockdown in HCC15 cells.
Source: GEO: Gene Expression Omnibus - September 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE158301 RNA-seq in RAW264.7 cells after silence of Synbindin in response to LPS
Contributors : Luoyan Ai ; Antao XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRAW264.7 cells were transfected with Synbindin siRNA for 48hours, then 100ng/ml LPS were treated cells for 4 hours. Before and after LPS stimulation, cells were collected and RNA were extracted for RNA-seq.
Source: GEO: Gene Expression Omnibus - September 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE92503 Transcriptome analysis of Streptococcus suis upon exposure to sub-lethal concentrations of LL-37
Contributors : Peter van Baarlen ; Gaiser Rogier ; Michiel WelsSeries Type : Expression profiling by arrayOrganism : Streptococcus suisStreptococcus suis is a major pig pathogen as well as an emerging zoonotic pathogen. We studied the generic and adaptive resistance response of S. suis upon exposure to sub-lethal concentrations of the human cathelicidin LL-37. We aimed to search for inducible mechanisms of resistance to AMPs as well as induction of virulence gene expression upon exposure to AMPs, in order to gain insights into host-derived factors that might mediate S. suis pathogenesis.
Source: GEO: Gene Expression Omnibus - September 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Streptococcus suis Source Type: research
GSE205981 RNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of lncRNA LINC00094 (SERLOC)
Contributors : Minna Piipponen ; Liisa Nissinen ; Veli-Matti K ähäriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Long non-coding RNAs (lncRNAs) are involved in various biological processes, and their role in cancer progression is emerging. Whole transcriptome analysis of cSCC cells (n=8) and normal human epidermal keratinocytes (NHEKs, n=4) revealed overexpression of long intergenic ncRNA (LINC00094) in cSCC cells (GSE66412). We wanted...
Source: GEO: Gene Expression Omnibus - August 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189140 MliR, a novel regulator of the MerR family involved in iron uptake
Contributors : Martin Aran ; Leonardo Pellizza ; Rodrigo Sieira ; Magali BialerSeries Type : Expression profiling by high throughput sequencingOrganism : Bizionia argentinensis JUB59The MerR family of transcriptional regulators are dimeric proteins with an N-terminal helix-turn-helix DNA binding domain (DBD), followed by an antiparallel coiled-coil subunit interaction region, and usually by a C-terminal effector binding domain (EBD). This family is distinguished by the high amino acid similarity in the DBD and low similarity in the EBD, consistent with the role of this domain in each protein in sensing effector molecules. ...
Source: GEO: Gene Expression Omnibus - August 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bizionia argentinensis JUB59 Source Type: research
