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Total 2210 results found since Jan 2013.
Real-World Data About Treatment Outcomes for Patients with EGFR-Mutated NSCLC Resistance to Osimertinib and Platinum-Based Chemotherapy
CONCLUSION: Given the limited real-world efficacy on EGFR-mutant NSCLC resistant to osimertinib and platinum-based chemotherapy, the development of more highly potent post-treatment therapies is warranted.PMID:37572265 | DOI:10.1007/s12325-023-02616-9
Source: Adv Data - August 12, 2023 Category: Epidemiology Authors: Hidetoshi Hayashi Makoto Nishio Michiko Takahashi Hiroaki Tsuchiya Mami Kasahara-Kiritani Source Type: research
Systemic therapies for high-volume metastatic hormone-sensitive prostate cancer: a network meta-analysis
CONCLUSIONS: REZ + ADT were the highest ranked doublet therapy for improvement in OS of patients with high-volume mHSPC, second only to triplet therapy (DAR + DOC + ADT and ABI + DOC + ADT).PMID:37548225 | DOI:10.1080/0284186X.2023.2241985
Source: Acta Oncologica - August 7, 2023 Category: Cancer & Oncology Authors: Zhonghan Zhou Shuai Liu Jingchang Mei Tian Liu Feng Liu Guiming Zhang Source Type: research
The CAIX inhibitor SLC-0111 exerts anti-cancer activity on gastric cancer cell lines and resensitizes resistant cells to 5-Fluorouracil, taxane-derived, and platinum-based drugs
Cancer Lett. 2023 Aug 5:216338. doi: 10.1016/j.canlet.2023.216338. Online ahead of print.ABSTRACTGastric cancer (GC) is the fifth most frequent malignancy and the fourth leading cause of worldwide cancer-related death. Despite the usage of multimodal perioperative chemotherapy (pCT), GC progressively gains chemoresistance, thereby, the identification of suitable targets to overcome drug resistance is fundamental. Amongst the potential biomarkers, carbonic anhydrase IX (CAIX) - associated with a poor prognosis of several solid cancers - has gained the most attention. In a cohort of GC patients who received perioperative FLO...
Source: Cancer Control - August 7, 2023 Category: Cancer & Oncology Authors: Elena Andreucci Alessio Biagioni Sara Peri Giampaolo Versienti Fabio Cianchi Fabio Staderini Lorenzo Antonuzzo Claudiu T Supuran Erika Olivo Elisa Pasqualini Luca Messerini Daniela Massi Matteo Lulli Jessica Ruzzolini Silvia Peppicelli Francesca Bianchini Source Type: research
Systemic therapies for high-volume metastatic hormone-sensitive prostate cancer: a network meta-analysis
CONCLUSIONS: REZ + ADT were the highest ranked doublet therapy for improvement in OS of patients with high-volume mHSPC, second only to triplet therapy (DAR + DOC + ADT and ABI + DOC + ADT).PMID:37548225 | DOI:10.1080/0284186X.2023.2241985
Source: Acta Oncologica - August 7, 2023 Category: Cancer & Oncology Authors: Zhonghan Zhou Shuai Liu Jingchang Mei Tian Liu Feng Liu Guiming Zhang Source Type: research
Characterization of tumor microenvironment infiltration and therapeutic responses of cell cycle-related genes' signature in breast cancer
CONCLUSION: The nomogram based on CCG could assess tumour immune micro-environment regulation and therapeutic responses of immunotherapy in BC. Moreover, it may provide novel information on the control of immune micro-environment infiltration in BC and aid in the development of targeted immunotherapy.PMID:37540256 | DOI:10.1007/s00432-023-05198-9
Source: Clinical Genitourinary Cancer - August 4, 2023 Category: Cancer & Oncology Authors: Huacong Wu Yutao Chen Mengyi Li Zijun Chen Jie Liu Guie Lai Source Type: research
A novel model based on disulfidptosis-related genes to predict prognosis and therapy of bladder urothelial carcinoma
CONCLUSION: The present study results suggest that disulfidptosis-related genes influence the prognosis of BLCA through their involvement in immune cell infiltration. Thus, these findings indicate the role of disulfidptosis in BLCA and its potential regulatory mechanisms.PMID:37541976 | DOI:10.1007/s00432-023-05235-7
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Shiyong Xin Ruixin Li Junjie Su Qiong Cao Haojie Wang Zhihao Wei Guanyu Li Wang Qin Zheng Zhang Chengliang Wang Chengdong Zhang Jianguo Zhang Source Type: research
Characterization of tumor microenvironment infiltration and therapeutic responses of cell cycle-related genes' signature in breast cancer
CONCLUSION: The nomogram based on CCG could assess tumour immune micro-environment regulation and therapeutic responses of immunotherapy in BC. Moreover, it may provide novel information on the control of immune micro-environment infiltration in BC and aid in the development of targeted immunotherapy.PMID:37540256 | DOI:10.1007/s00432-023-05198-9
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Huacong Wu Yutao Chen Mengyi Li Zijun Chen Jie Liu Guie Lai Source Type: research
A novel model based on disulfidptosis-related genes to predict prognosis and therapy of bladder urothelial carcinoma
CONCLUSION: The present study results suggest that disulfidptosis-related genes influence the prognosis of BLCA through their involvement in immune cell infiltration. Thus, these findings indicate the role of disulfidptosis in BLCA and its potential regulatory mechanisms.PMID:37541976 | DOI:10.1007/s00432-023-05235-7
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Shiyong Xin Ruixin Li Junjie Su Qiong Cao Haojie Wang Zhihao Wei Guanyu Li Wang Qin Zheng Zhang Chengliang Wang Chengdong Zhang Jianguo Zhang Source Type: research
Characterization of tumor microenvironment infiltration and therapeutic responses of cell cycle-related genes' signature in breast cancer
CONCLUSION: The nomogram based on CCG could assess tumour immune micro-environment regulation and therapeutic responses of immunotherapy in BC. Moreover, it may provide novel information on the control of immune micro-environment infiltration in BC and aid in the development of targeted immunotherapy.PMID:37540256 | DOI:10.1007/s00432-023-05198-9
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Huacong Wu Yutao Chen Mengyi Li Zijun Chen Jie Liu Guie Lai Source Type: research
