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Total 6511 results found since Jan 2013.
Novel pharmacological approaches in abdominal aortic aneurysm
Clin Sci (Lond). 2023 Aug 14;137(15):1167-1194. doi: 10.1042/CS20220795.ABSTRACTAbdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: L ídia Puertas-Umbert Rafael Almendra-Pegueros Francesc Jim énez-Altayó Marc Sirvent Mar ía Galán Jos é Martínez-González Cristina Rodr íguez Source Type: research
Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes
Clin Immunol. 2023 Aug 8:109729. doi: 10.1016/j.clim.2023.109729. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune disease characterized by the immune system's failure to maintain self-tolerance, resulting in the autoimmune destruction of pancreatic beta cells. Although T1D has conventionally been viewed as a T-cell-dominant disease, recent research has emphasized the contribution of B cells in the onset of the disease. However, the mechanism underlying aberrant B cell responses remains unknown. B cell metabolism is a crucial prerequisite for B cell function and the development of adaptive immune respon...
Source: Clinical Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Zeying Li Mingjiu Zhao Jingyue Li Wenjun Luo Juan Huang Gan Huang Zhiguo Xie Yang Xiao Jiaqi Huang Xia Li Bin Zhao Zhiguang Zhou Source Type: research
Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis
CONCLUSIONS: The choice of metformin or COCP treatment should be based on symptoms, noting that there are some biochemical benefits from combination treatment, targeting both major endocrine disturbances seen in PCOS; hyperinsulinemia and hyperandrogenism.PMID:37554096 | DOI:10.1210/clinem/dgad465
Source: The Journal of Clinical Endocrinology and Metabolism - August 9, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research
Influence of Solute Carrier Family 22 Member 1 (SLC22A1) Gene Polymorphism on Metformin Pharmacokinetics and HbA1c Levels: A Systematic Review
CONCLUSION: Three studies found that rs12208357, rs34059508, and G465R had a considerable impact (p < 0.05) on metformin pharmacokinetics, resulting in increased metformin plasma (Cmax), a higher active amount of drug in the blood (AUC), and lower volume of distribution (Vd) (p<0.05). SLC22A1 polymorphisms with effects on HbA1c include rs628031 (four of seven studies), rs622342 (four of six studies), rs594709 (one study), rs2297374, and rs1867351 (one of two studies), rs34130495 (one study), and rs11212617 (one study) (p < 0.05).PMID:37550919 | DOI:10.2174/1573399820666230807145202
Source: Current Diabetes Reviews - August 8, 2023 Category: Endocrinology Authors: Dimas Adhi Pradana Erna Kristin Dwi Aris Agung Nugrahaningsih Akhmad Kharis Nugroho Rizaldi Taslim Pinzon Source Type: research
New Inspirations from Discovering the Molecular Target of Metformin
Curr Pharm Des. 2023 Aug 7. doi: 10.2174/1381612829666230807160956. Online ahead of print.NO ABSTRACTPMID:37550903 | DOI:10.2174/1381612829666230807160956
Source: Current Pharmaceutical Design - August 8, 2023 Category: Drugs & Pharmacology Authors: Chengfei Zhao Source Type: research
Influence of Solute Carrier Family 22 Member 1 (SLC22A1) Gene Polymorphism on Metformin Pharmacokinetics and HbA1c Levels: A Systematic Review
CONCLUSION: Three studies found that rs12208357, rs34059508, and G465R had a considerable impact (p < 0.05) on metformin pharmacokinetics, resulting in increased metformin plasma (Cmax), a higher active amount of drug in the blood (AUC), and lower volume of distribution (Vd) (p<0.05). SLC22A1 polymorphisms with effects on HbA1c include rs628031 (four of seven studies), rs622342 (four of six studies), rs594709 (one study), rs2297374, and rs1867351 (one of two studies), rs34130495 (one study), and rs11212617 (one study) (p < 0.05).PMID:37550919 | DOI:10.2174/1573399820666230807145202
Source: Current Diabetes Reviews - August 8, 2023 Category: Endocrinology Authors: Dimas Adhi Pradana Erna Kristin Dwi Aris Agung Nugrahaningsih Akhmad Kharis Nugroho Rizaldi Taslim Pinzon Source Type: research
New Inspirations from Discovering the Molecular Target of Metformin
Curr Pharm Des. 2023 Aug 7. doi: 10.2174/1381612829666230807160956. Online ahead of print.NO ABSTRACTPMID:37550903 | DOI:10.2174/1381612829666230807160956
Source: Current Pharmaceutical Design - August 8, 2023 Category: Drugs & Pharmacology Authors: Chengfei Zhao Source Type: research
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis
In this study, we observed significant ferroptosis in NIT-1 cells and primary mouse islets after exposure to high glucose and palmitate (HG/PA). Compared to Exe and Sax, Met significantly alleviated glucolipotoxicity-induced pancreatic β cell ferroptosis. Blocking the activity of glutathione peroxidase 4 (GPX4) with Ras-selective lethal 3 or inhibiting its expression by small interfering RNA transfection significantly attenuated the anti-ferroptosis effects of Met. Mechanistically, Met alleviates HG/PA-induced β cell ferroptosis by regulating the GPX4/ACSL4 axis. Collectively, our findings highlight the significance of f...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Yue Sun Li-Qun Guo De-Guo Wang Yu-Jie Xing Ya-Ping Bai Teng Zhang Wen Wang Si-Min Zhou Xin-Ming Yao Jin-Han Cheng Wei-Wei Chang Kun Lv Chun-Xiao Li Xiang Kong Source Type: research
Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade
This study aims to investigate the effect of curcumin (Cur) and resveratrol (Res) as a potential combination therapy on MAFLD. Cur, Res and Cur+Res were tested in palmitic acid (PA)-induced-HepG2 cells. MAFLD model was established using Goto-Kakizaki rats. The animals were treated with vehicle control (model group), Cur (150 mg/kg), Res (150 mg/kg), Cur+Res (150 mg/kg, 8:2, w/w), or metformin (Met, positive control, 400 mg/kg/day) via oral gavage for 4 weeks. Wistar rats were used as the control group. Network pharmacology was conducted to elucidate the molecular actions of Cur and Res, followed by q-PCR and immunoblotting...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2023 Category: Drugs & Pharmacology Authors: Yuhui He Huan Wang Shiling Lin Tao Chen Dennis Chang Yibin Sun Chenxiang Wang Yang Liu Yusheng Lu Jianyuan Song Shaohua Li Wen Xu Yanxiang Lin Yanfang Zheng Xian Zhou Qiumei Huang Mingqing Huang Source Type: research
