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GSE179496 Targeting the Viral Suppressor of RNAi Provides a Novel Strategy for Antiviral Therapy
Contributors : Yuan Fang ; Zezhong Liu ; Yang Qiu ; Jing Kong ; Yuhong Fu ; Yujie Liu ; Chong Wang ; Jia Quan ; Qian Wang ; Wei Xu ; Lei Yin ; Jie Cui ; Yi Xu ; Stephen Curry ; Shibo Jiang ; Lu Lu ; Xi ZhouSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Enterovirus A71RNA interference (RNAi) is an antiviral immunity conserved in diverse eukaryotes including mammals, while viruses encodes viral suppressors of RNAi (VSRs) as countermeasures. However, the physiological impact of RNAi on viral infection in mammals has not been fully assessed, and it also remains unknown whether antiviral RNAi can...
Source: GEO: Gene Expression Omnibus - July 31, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Enterovirus A71 Source Type: research

Susceptibility of Enterovirus-D68 to RNAi-mediated antiviral knockdown
Publication date: Available online 20 July 2019Source: Antiviral ResearchAuthor(s): Nicholas Klaiber, Michael A. McVoy, Wei ZhaoAbstractEnterovirus D68 (EV-D68) represents an emerging pathogen which has demonstrated a capacity for causing epidemic illness in pediatric and immunocompromised patients. With no effective antiviral treatment available, therapeutic interventions are currently limited to supportive care. Utilizing available genomic sequences from the 2014 B3 Epidemic EV-D68 clade and the 1962 Fermon EV-D68 strains, we performed in silico comparative genomic analysis, identifying several islands of phylogenetic co...
Source: Antiviral Therapy - July 21, 2019 Category: Virology Source Type: research

Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-{alpha}1 degradation Immunology
In this study, we found that in cells pretreated with IFN-β, EV71 infection could still lead to a cytopathic effect, and the viral replication was not affected. The mechanism by which EV71 antagonizes interferon signaling, however, has been controversial. Our study indicated that EV71 infection did not inhibit phosphorylation of STAT1/2 induced by IFN-β stimulation, but p-STAT1/2 transport into the nucleus was significantly blocked. We showed that EV71 infection reduced the formation of STAT/karyopherin-α1 (KPNA1) complex upon interferon stimulation and that the virus down-regulated the expression of KPNA1, a nuclear lo...
Source: Journal of Biological Chemistry - June 16, 2017 Category: Chemistry Authors: Chunyang Wang, Menghuai Sun, Xinhui Yuan, Lianfu Ji, Yu Jin, Carol J. Cardona, Zheng Xing Tags: Microbiology Source Type: research

Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor
Publication date: Available online 17 April 2017 Source:Antiviral Research Author(s): Kan Xing Wu, Justin Jang-Hann Chu Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease (HFMD) associated with severe neurological disease. EV71's pathogenesis remains poorly understood and the lack of approved antiviral has led to its emergence as a clinically important neurotropic virus. The goals of this study were to: (i) identify novel anti-EV71 compounds that may serve as lead molecules for therapeutics; and (ii) investigate their targets in downstream studies. We screened a 502-compound library of hi...
Source: Antiviral Therapy - April 17, 2017 Category: Virology Source Type: research