• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Activation of RAS contributes to peritoneal fibrosis via dysregulation of low-density lipoprotein receptor.
In conclusion, increased intracellular RAS activity impaired lipid homeostasis and induced ECM accumulation in HPMCs by disrupting the LDLr pathway, which contributed to PF. PMID: 33427062 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - January 11, 2021 Category: Urology & Nephrology Authors: Liu J, Feng Y, Li N, Shao QY, Zhang Q, Sun C, Xu P, Jiang CM Tags: Am J Physiol Renal Physiol Source Type: research

Elevated expression of HDAC6 in clinical peritoneal dialysis patients and its pathogenic role on peritoneal angiogenesis.
In this study, we analyzed the expression of HDAC6 in the peritoneum from patients with non-PD and PD-related peritonitis and dialysis effluent from stable PD patients. Our study revealed that HDAC6 expressed highly in the peritoneum with peritonitis and co-stained with α-smooth muscle actin (α-SMA), a biomarker of the myofibroblast. And the level of HDAC6 in the dialysate increased with time and positively correlated with transforming growth factor-β1 (TGF-β1), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), and negatively with cancer antigen 125 (CA125). In vitro, blockading HDAC6 with a selective...
Source: Renal Failure - September 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells.
Abstract Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by rapamycin...
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Liu J, Zhu W, Jiang CM, Feng Y, Xia YY, Zhang QY, Xu PF, Zhang M Tags: Am J Nephrol Source Type: research

The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions
Conclusions Overexpression of FoxO1 caused upregulation of p27, which promoted cell cycle arrest and inhibited hyperproliferation of MCs induced by HG. Degradation of FoxO1 caused an increase in p27 and stimulated MC proliferation. These findings unveil part of the molecular mechanism of FoxO1 regulation of MC hyperproliferation induced by HG.
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Liu, F., Ma, X.-J., Wang, Q.-Z., Zhao, Y.-Y., Wu, L.-N., Qin, G.-J. Tags: BASIC SCIENCE Source Type: research

Experimental acute kidney injury
Conclusions: WNT10A expression may promote fibrotic progression and kidney dysfunction in AIN. Blockade of WNT10A expression may be a feasible therapeutic strategy against kidney fibrosis.
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Kuma, A., Yamada, S., Miyamoto, T., Serino, R., Tamura, M., Otsuji, Y., Kohno, K., Cho, W. Y., Kim, M.-G., Jo, S.-K., Kim, H. K., Jado, J. C., Humanes, B., Lopez-Parra, V., Camano, S., Lara, J. M., Cercenado, E., Tejedor, A., Lazaro, A., Jansen, M., Caste Tags: Sunday, June 1st, 2014: Posters Source Type: research

Cell signalling and apoptosis
Conclusions: These results suggest that activation of S1P signaling mediated by S1PR-3 results in chronic pathological fibrosis, such as in chronic kidney disease (CKD).
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Shiohira, S., Yoshida, T., Sugiura, H., Nishida, M., Nitta, K., Tsuchiya, K., Grampp, S., Goppelt-Strube, M., Eckardt, K. U., Schodel, J., Kang, S. W., Kim, Y., Seo, S.-K., Kim, T., Ong, S., Yang, W. S., Han, N. J., Lee, J. M., Baek, C. H., Park, S.-K., K Tags: Monday, June 2nd, 2014: Posters Source Type: research

Tubular ischemia and toxicity
Conclusions: EPC-derived EVs protect the kidney from ischemic AKI by delivering mRNAs coding for factor H, DAF and CD59 to injured tubular epithelial and endothelial cells. These results confirmed previous data on the relevance of complement inhibition after kidney IRI and suggest the potential use of EPC-derived EVs as therapeutic option to avoid delayed graft function after kidney transplantation.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Cantaluppi, V., Medica, D., Figliolini, F., Gatti, S., Bruno, S., Quercia, A. D., Dellepiane, S., Biancone, L., Tetta, C., Camussi, G., Zhou, L., Dai, X., Feng, M., Huang, X., Fu, P., Lan, H. Y., de Ramon, L., Ripoll, E., Luzardo, L., Merino, A., Bolanos, Tags: Abstracts Source Type: research

Cell signalling
Conclusions: Taken together, it is likely that klotho protects against renal fibrotic process accompanied by down-regulation of fibrotic markers, counteracting to TGF-β, and one of possible mechanism mediating translocation of Na/K ATPase, resulting in Ca+ channel stabilization/alternation of Ca+ ion concentration. Klotho should be involved in the accentuation of the progression of renal fibrosis in CKD.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Tsuchiya, K., Shiohira, S., Sugiura, H., Suzuki, M., Okano, K., Nitta, K., Kaesler, N., Immendorf, S., Ouyang, C., Carmeliet, P., Floege, J., Kruger, T., Schlieper, G., Georgescu, A., Kalucka, J., Olbrich, S., Baumgartl, J., Hackenbeck, T., Eckardt, K.-U. Tags: Abstracts Source Type: research