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Specialty: Cardiology
Procedure: Gastroschisis Repair
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Total 24 results found since Jan 2013.
FUS regulates the alternative splicing of cell proliferation genes related to atherosclerosis
Exp Biol Med (Maywood). 2023 Sep 9:15353702231187642. doi: 10.1177/15353702231187642. Online ahead of print.ABSTRACTFUS plays a significant role as an RNA-binding protein in several cellular processes, including RNA splicing, DNA repair, and transcriptional regulation. However, the RNA-binding capacity of FUS in atherosclerosis is unclear. We aimed to study the functions of FUS in inflammatory regulation through the role of the splicing factor. We knocked down FUS with siRNA to further study the overall transcriptional level and select alternative splicing (AS) of FUS regulation in human umbilical vein endothelial cells (H...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Jianjun Hou Shaobing Yang Ying Guo Ning Yan Shaobin Jia Source Type: research
MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis
Bioengineered. 2022 Apr;13(4):11214-11227. doi: 10.1080/21655979.2022.2063496.ABSTRACTEndothelial dysfunction is an initial and essential step in vascular-remodeling diseases, including atherosclerosis and neointima formation. During vascular remodeling, activated endothelial cells can release pro-inflammatory factors that promote phenotypic switching of vascular smooth muscle cells (VSMCs) to the proliferative phenotype. We previously reported that MEK1/2 inhibitor, U0126, has a protective effect on the development of atherosclerosis and vascular calcification. However, the effect of MEK1/2 inhibitors on neointimal format...
Source: Atherosclerosis - April 29, 2022 Category: Cardiology Authors: Yali Yan Mengmeng Zhu Jialing Ma Xiaoyu He Xiaoxiao Yang Hongmei Xu Meixiu Jiang Shuang Zhang Yajun Duan Jihong Han Yuanli Chen Source Type: research
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart
Conclusions: Our data demonstrates that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling thus augmenting removal of apoptotic cells, resolution of inflammation and therefore efficient cardiac recovery after injury.PMID:34623174 | DOI:10.1161/CIRCRESAHA.120.317900
Source: Circulation Research - October 8, 2021 Category: Cardiology Authors: Mallikarjun Patil Sherin Saheera Praveen K Dubey Asher Kahn-Krell Prem Kumar Govindappa Sarojini Singh Sultan Tousif Qinkun Zhang Hind Lal Jianyi Zhang Gangjian Qin Prasanna Krishnamurthy Source Type: research
miR-106a –363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury
AbstractEndogenous capability of the post-mitotic human heart holds great promise to restore the injured myocardium. Recent evidence indicates that the extracellular vesicles (EVs) regulate cardiac homeostasis and regeneration. Here, we investigated the molecular mechanism of EVs for self-repair. We isolated EVs from human iPSC-derived cardiomyocytes (iCMs), which were exposed to hypoxic (hEVs) and normoxic conditions (nEVs), and examined their roles in in vitro and in vivo models of cardiac injury. hEV treatment significantly improved the viability of hypoxic iCMs in vitro and cardiac function of severely injured murine m...
Source: Basic Research in Cardiology - March 19, 2021 Category: Cardiology Source Type: research
From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases
AbstractNucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of nucleic acid-based therapies; (iii) they enable effective modulation of therapeutic targets that cannot be sufficiently or optimally addressed using traditional small molecule drugs or antibodies. Nucleic acid-based therapeutics include (i) RNA-targeted therapeutics for gene silencing; (ii) microRNA-mo...
Source: European Heart Journal - April 29, 2020 Category: Cardiology Source Type: research
The Long Non-Coding RNA CPR Regulates Cardiomyocyte Proliferation and Cardiac Repair.
CONCLUSIONS: Together, our findings identified that CPR is a suppressor of cardiomyocyte proliferation, and it indicates that lncRNA(s) take parts in the regulation of cardiomyocyte proliferation and cardiac repair. Our study provides an lncRNA-based therapeutic strategy for effective cardiac repair and regeneration.
PMID: 30832495 [PubMed - as supplied by publisher]
Source: Circulation - March 4, 2019 Category: Cardiology Authors: Ponnusamy M, Liu F, Zhang YH, Li RB, Zhai M, Liu F, Zhou LY, Liu CY, Yan KW, Dong YH, Wang M, Qian LL, Shan C, Xu S, Wang Q, Zhang YH, Li PF, Zhang J, Wang K Tags: Circulation Source Type: research
S1P-S1PR2 Axis Mediates Homing of Muse Cells into Damaged Heart for Long Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction.
Conclusions: Muse cells may provide reparative effects and robust functional recovery, and may thus provide a novel strategy for the treatment of AMI.
PMID: 29475983 [PubMed - as supplied by publisher]
Source: Circulation Research - February 23, 2018 Category: Cardiology Authors: Yamada Y, Wakao S, Kushida Y, Minatoguchi S, Mikami A, Higashi K, Baba S, Shigemoto T, Kuroda Y, Kanamori H, Amin M, Kawasaki M, Nishigaki K, Taoka M, Isobe T, Muramatsu C, Dezawa M, Minatoguchi S Tags: Circ Res Source Type: research
A Cytokine-like Protein DKK3 Is Atheroprotective.
Conclusions -This study provides the evidence for a role of DKK3 in the protection against atherosclerosis involving endothelial migration and repair, with great therapeutic potential implications against atherosclerosis.
PMID: 28674110 [PubMed - as supplied by publisher]
Source: Circulation - July 3, 2017 Category: Cardiology Authors: Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Del Barco Barrantes I, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A, Xu Q Tags: Circulation Source Type: research
Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-kit+ progenitor cells
Cardiac c-kit+ progenitor cells are important for maintaining cardiac homeostasis and can potentially contribute to myocardial repair. However, cellular physiology of human cardiac c-kit+ progenitor cells is not well understood. The present study investigates the functional store-operated Ca2+ entry (SOCE) channels and the potential role in regulating cell cycling and migration using confocal microscopy, RT-PCR, Western blot, coimmunoprecipitation, cell proliferation, and migration assays. We found that SOCE channels mediated Ca2+ influx, and TRPC1, STIM1, and Orai1 were involved in the formation of SOCE channels in human ...
Source: AJP: Heart and Circulatory Physiology - November 15, 2015 Category: Cardiology Authors: Che, H., Li, G., Sun, H.-Y., Xiao, G.-S., Wang, Y., Li, G.-R. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research
