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Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research

Post-Ganglionic Sympathetic Neurons can Directly Sense Raised Extracellular Na+ via SCN7a/Nax
The relationship between dietary NaCl intake and high blood pressure is well-established, and occurs primarily through activation of the sympathetic nervous system. Nax, a Na+-sensitive Na+ channel, plays a pivotal role in driving sympathetic excitability, which is thought to originate from central regions controlling neural outflow. We investigated whether post-ganglionic sympathetic neurons from different ganglia innervating cardiac and vasculature tissue can also directly sense extracellular Na+. Using whole-cell patch clamp recordings we demonstrate that sympathetic neurons from three sympathetic ganglia (superior cerv...
Source: Frontiers in Physiology - June 17, 2022 Category: Physiology Source Type: research

Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase ‐2 expression and proliferation
We hypothesized that the release of epidermal growth factor (EGF) by human pulmonary microvascular endothelial cells (hPMVEC) could result in the proliferation of human pulmonary arterial smooth muscle cells via activation of the EGF receptor (EGFR) on the hPASMC leading to Arg2 up-regulation. Our data suggest that hypoxic hPMVEC do release EGF, which activates hPASMC EGFR leading to Arg2 protein expression and an increase in viable smooth muscle cell numbers. AbstractThe hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) re...
Source: Physiological Reports - June 9, 2022 Category: Physiology Authors: Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. Nelin Tags: ORIGINAL ARTICLE Source Type: research

Mechanical Strain Regulates Myofibroblast Differentiation of Human Scleral Fibroblasts by YAP
In conclusion, mechanical strain activated scleral myofibroblast differentiation via YAP. The YAP pathway may play an important role in regulating scleral myofibroblast differentiation and ECM remodeling of the sclera in glaucoma.
Source: Frontiers in Physiology - September 30, 2021 Category: Physiology Source Type: research

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