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Therapy: Stem Cell Therapy

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Total 19 results found since Jan 2013.

Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF- α by reduction of fatty acid β-oxidation and anti-oxidation
Free Radic Biol Med. 2022 Sep 9:S0891-5849(22)00583-4. doi: 10.1016/j.freeradbiomed.2022.09.002. Online ahead of print.ABSTRACTTumor necrosis factor-α (TNF-α) is an inflammatory cytokine involved in cell survival, apoptosis, and homeostasis. However, the regulatory effect of TNF-α on mesenchymal stem cell (MSC) redox regulation remains unknown. The process of delaying the senescence of MSCs and maintaining antioxidation mechanism is important in transplantation therapy to treat inflammatory diseases that result from restricted immunomodulatory effects of senescent MSCs. Thus, we examined the role of TNF-α-mediated sign...
Source: Free Radical Biology and Medicine - September 12, 2022 Category: Biology Authors: Young Hyun Jung Chang Woo Chae Han Seung Chang Gee Euhn Choi Hyun Jik Lee Ho Jae Han Source Type: research

Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR δ for antioxidant action
Free Radic Biol Med. 2022 Jan 27:S0891-5849(22)00033-8. doi: 10.1016/j.freeradbiomed.2022.01.022. Online ahead of print.ABSTRACTCerebral ischemic stroke ranks the second leading cause of death and the third leading cause of disability in lifetime all around the world, urgently necessitating effective therapeutic interventions. Reactive oxygen species (ROS) have been implicated in stroke pathogenesis and peroxisome proliferator-activated receptors (PPARs) are prominent targets for ROS management. Although recent research has shown antioxidant effect of berberine (BBR), little is known regarding its effect upon ROS-PPARs sig...
Source: Free Radical Biology and Medicine - January 30, 2022 Category: Biology Authors: Jia-Wen Shou Xiao-Xiao Li Yun-Sang Tang Bobby Lim-Ho Kong Hoi-Yan Wu Meng-Jie Xiao Chun-Kai Cheung Pang-Chui Shaw Source Type: research

Induction of let-7e gene expression attenuates oncogenic phenotype in HCT-116 colorectal cancer cells through targeting of DCLK1 regulation
Publication date: Available online 8 May 2019Source: Life SciencesAuthor(s): Alisa Khodadadi Kohlan, Massoud Saidijam, Razieh Amini, Pouria Samadi, Rezvan NajafiAbstractAimsMicroRNAs (miRNAs) are small noncoding RNAs that negatively control gene expression at the translational level. There are compelling evidences indicating that the expression of let-7e is downregulated in various cancers, however, the role of let-7e in colorectal cancer (CRC) and its mechanism has been remained unknown. Here, we investigated the potential role of let-7e in regulating CRC cells phenotypes.Main methodsLet-7e and DCLK1 siRNA were transfecte...
Source: Life Sciences - May 8, 2019 Category: Biology Source Type: research

MicroRNA-320c inhibits development of osteoarthritis through downregulation of canonical Wnt signaling pathway
Publication date: Available online 8 May 2019Source: Life SciencesAuthor(s): Shu Hu, Guping Mao, Ziji Zhang, Peihui Wu, Xingzhao Wen, Weiming Liao, Zhiqi ZhangAbstractAimsOsteoarthritis (OA) is a leading cause of deformity in aging people. Emerging evidence suggests that microRNAs and Wnt signaling pathway are associated with its pathogenesis. We aimed to determine whether microRNA-320c inhibits the development of osteoarthritis by suppressing Wnt signaling pathway.Materials and methodsMiR-320c and β-catenin expression was assessed in human adipose derived stem cells (hADSCs) model of chondrogenesis and in normal and OA p...
Source: Life Sciences - May 8, 2019 Category: Biology Source Type: research

Sphingosine 1-phosphate promotes mesenchymal stem cell-mediated cardioprotection against myocardial infarction via ERK1/2-MMP-9 and Akt signaling axis
Publication date: Available online 24 October 2018Source: Life SciencesAuthor(s): Ruirui Chen, Xiqiang Cai, Jing Liu, Baobao Bai, Xue LiAbstractAimsThe sphingolipid metabolite sphingosine 1‑phosphate (S1P) has emerged as a potential cardioprotective molecule against ischemic heart disease. Moreover, S1P triggers mobilization and homing of bone marrow-derived stem/progenitor cells into the damaged heart. However, it remains elusive whether S1P promotes mesenchymal stem cells (MSCs)-mediated cardioprotection against ischemic heart diseases.Main methodsAdipose tissue-derived MSCs (AT-MSCs) were obtained from GFP transgenic ...
Source: Life Sciences - October 24, 2018 Category: Biology Source Type: research

Neuralized1a regulates asymmetric division in mouse Lewis lung carcinoma cells
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Liangsheng Kong, Jingyuan Li, Yongli Liu, Zhiwei Sun, Shixia Zhou, Junling Tang, Ting Ye, Jianyu Wang, H. Rosie XingAbstractAsymmetric division (ASD), the unique characteristic of normal stem cells, is regarded as a stemness marker when applied to the study of cancer stem cells (CSCs). However, the role of ASD in the self-renewal of CSCs and its regulation remain largely unknown. Here, we first established a mouse Lewis lung carcinoma CSC cell line that could undergo asymmetric division (LLC-ASD cells) derived from the parental mouse Lewis lung carc...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK
Publication date: 15 December 2017 Source:Life Sciences, Volume 191 Author(s): Ying Wang, Yanli Xia, Dong Kuang, Yaqi Duan, Guoping Wang Aims Previous studies have shown that stem cell factor (SCF) induces the migration of cardiac stem cells (CSCs) and helps to repair myocardial infarctions. Earlier studies on the migration mechanism only focused on the activation of kinases; here, we aimed to explore the functional role of protein phosphatase 2A (PP2A) in SCF-induced CSC migration. Main methods CSCs were treated with SCF, PP2A enzymatic activity was measured, the phosphorylation levels of PP2A, p38 MAPK and cofilin were ...
Source: Life Sciences - October 14, 2017 Category: Biology Source Type: research

Acquired expression of osteopontin selectively promotes enrichment of leukemia stem cells through AKT/mTOR/PTEN/β-catenin pathways in AML cells
Publication date: 1 May 2016 Source:Life Sciences, Volume 152 Author(s): Saeed Mohammadi, Seyed H. Ghaffari, Mojgan Shaiegan, Mahin Nikougoftar Zarif, Mohsen Nikbakht, Shiva Akbari Birgani, Kamran Alimoghadam, Ardeshir Ghavamzadeh Aims Acute myeloid leukemia (AML) initiation and progression have been attributed to subpopulations of self-renewing leukemia stem cells (LSCs), which contribute to progression, recurrence and therapeutic resistance in leukemia. Osteopontin (OPN) plays an important role in promoting survival and drug resistance in LSCs. The aim of this study was to explore OPN roles in modulating curcum...
Source: Life Sciences - May 2, 2016 Category: Biology Source Type: research

Effects of IGF-1 on neural differentiation of human umbilical cord derived mesenchymal stem cells
This study indicated that IGF-1 could improve neural differentiation of human UC-MSCs and provided a novel strategy to enhance astrocyte differentiation of NPCs from UC-MSCs.
Source: Life Sciences - March 3, 2016 Category: Biology Source Type: research

Exendin-4 protects adipose-derived mesenchymal stem cells from apoptosis induced by hydrogen peroxide through the PI3K/Akt-Sfrp2 pathways.
Abstract Adipose-derived mesenchymal stem cells (ADMSCs)-based therapy is a promising modality for the treatment of myocardial infarction in the future. However, the majority of transplanted cells are readily lost after transplantation because of hypoxia and oxidative stress. An efficient means to enhance the ability of ADMSCs to survive under pathologic conditions is required. In our study, we explored the effects of exendin-4 (Ex-4) on ADMSCs apoptosis in vitro induced by hydrogen peroxide, focusing in particular on mitochondrial apoptotic pathways and PI3K/Akt-secreted frizzled-related protein 2 (Sfrp2) surviva...
Source: Free Radical Biology and Medicine - October 16, 2014 Category: Biology Authors: Zhou H, Yang J, Xin T, Li D, Guo J, Hu S, Zhou S, Zhang T, Zhang Y, Han T, Chen Y Tags: Free Radic Biol Med Source Type: research

Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells
Conclusions: Our results provide the first evidence that a natural anti-cancer compound mediates its cellular and in vivo tumor anti-proliferative responses by selectively stimulating cellular interactions of the stem/progenitor cell marker nucleostemin with MDM2, which frees p53 to trigger its apoptotic response. Furthermore, our study provides a new mechanistic template that can be potentially exploited for the development of cancer stem/progenitor cell targeted therapeutic strategies.
Source: BMC Biology - Latest articles - September 12, 2014 Category: Biology Authors: Antony TinAnna ParkShyam SundarGary Firestone Source Type: research