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ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF- κB Signal Pathways
Biol Trace Elem Res. 2022 Jul 23. doi: 10.1007/s12011-022-03361-w. Online ahead of print.ABSTRACTApoptosis of kidney tubular epithelial cells contributes to diabetic kidney disease (DKD) pathophysiology, but the mechanisms are not fully understood. Zinc transporter protein member 8 (ZnT8, SLC30A8) is a susceptive gene in diabetes. Here, we aim to investigate whether ZnT8 has effects on pathophysiology of DKD. The animal groups include control, ZnT8KO mice, STZ-induced, and ZnT8-KO-STZ. STZ-induced DKD was performed in male C57BL/6 J mice and in ZnT8-KO mice. High glucose (HG)-induced apoptosis in a normal rat kidney tubula...
Source: Biological Trace Element Research - July 23, 2022 Category: Biology Authors: Yinmao Chi Xiuli Zhang Dan Liang Yue Wang Xiaoyi Cai Jiqiu Dong Lingzhi Li Zhihong Chi Source Type: research

Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins
Publication date: Available online 5 August 2019Source: Life SciencesAuthor(s): Hu Li, Rahmani Mohammad Malyar, Nianhui Zhai, Hong Wang, Kai Liu, Dandan Liu, Cuiling Pan, Fang Gan, Kehe Huang, Jinfeng Miao, Xingxiang ChenAbstractAimsThe present study was to investigate the protective effects of Zn supplementation in OTA-induced apoptosis of Madin-Darby canine kidney (MDCK) epithelial cells and explore the potential mechanisms. Aiming to provides a new insight into the treatment strategy of OTA-induced nephrotoxicity by nutritional regulation.Main methodsInitially, through MTT and LDH assay revealed that Zn supplementation ...
Source: Life Sciences - August 18, 2019 Category: Biology Source Type: research

Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Yan He, Xiaoming Yuan, Hao Zuo, Xiangwei Li, Ying Sun, Aiwen FengAbstractAimsThe present study investigated if berberine might induce Zrt-Irt-like protein 14 (ZIP14) and affect zinc redistribution to protect intestinal barrier in sepsis.Main methodsRodent model of sepsis was induced by cecal ligation and puncture (CLP). Plasma endotoxin was assayed by LAL test and plasma zinc was measured by flame atomic spectrophotometer. Gut mucosal permeability was determined by plasma FITC-dextran. Zinc content and ZIP14 mRNA in gut mucosa were assayed by sp...
Source: Life Sciences - July 31, 2019 Category: Biology Source Type: research

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival
In conclusion, we clarified the relationship between acceleration of the autophagy pathway and the cytoprotective effects of Nrf2 activation in RPE cells and zebrafish retina. These findings indicated that Nrf2 activation could be a promising therapeutic approach for non-exudative AMD by supporting RPE maintenance.Graphical abstract
Source: Redox Biology - September 5, 2018 Category: Biology Source Type: research

Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control
Publication date: Available online 8 March 2018 Source:Life Sciences Author(s): Jeong-Min Hong, Sun-Mee Lee Aims Heme oxygenase-1 (HO-1), an endogenous cytoprotective enzyme, is reported that can be localized in mitochondria under stress, contributing to preserve mitochondrial function. Mitochondrial quality control (QC) is essential to cellular health and recovery linked with redox homeostasis. Recent studies reported that phosphoglycerate mutase family member (PGAM) 5, a mitochondria-resident phosphatase, plays critical role in mitochondrial homeostasis. Therefore, we aim to investigate cytoprotective mechanisms of HO-1...
Source: Life Sciences - March 8, 2018 Category: Biology Source Type: research

Zinc Regulates Nox1 Expression Through a NF- κB and Mitochondrial ROS Dependent Mechanism to Induce Senescence of Vascular Smooth Muscle Cells.
CONCLUSION: Our data demonstrate that altered zinc distribution leading to accumulation of zinc in the mitochondria increases mitochondrial ROS production causing NF-κB activation which in turn upregulates Nox1 expression inducing senescence of VSMCs. PMID: 28363602 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 29, 2017 Category: Biology Authors: Salazar G, Huang J, Feresin RG, Zhao Y, Griendling KK Tags: Free Radic Biol Med Source Type: research