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Total 61 results found since Jan 2013.

CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77
CONCLUSIONS: Since CC1007 demonstrates remarkable anti-MM effect on MM cells, it may be a promising drug for the treatment of MM.PMID:36283176 | DOI:10.1016/j.bioorg.2022.106217
Source: Bioorganic Chemistry - October 25, 2022 Category: Chemistry Authors: Shicong Zhu Cheng Xing Guangsen Zhang Hongling Peng Zhihua Wang Source Type: research

Mitochondrial translocation of P66Shc aggravates cisplatin- induced AKI by promoting ferroptosis
CONCLUSION: Mitochondrial translocation of P66Shc could result in mitochondrial injury and lipid peroxide accumulation, which ultimately led to ferroptosis and aggravated CP-induced AKI.PMID:35986536 | DOI:10.2174/0929867329666220819112808
Source: Current Medicinal Chemistry - August 20, 2022 Category: Chemistry Authors: Ming Yang Yu-Ting Liu Ya-Chun Han Wei Zhang Hao Zhang Shikun Yang Source Type: research

Molecules, Vol. 27, Pages 1990: Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway
In this study, we evaluated the effect of homoplantaginin and its derivative dihydrohomoplantagin on oxLDL-induced endothelial cell injury and atherosclerosis in apoE-/- mice. Our results showedthat both dihydrohomoplantagin and homoplantaginin inhibited apoptosis and the increased level of ICAM-1 and VCAM-1 in oxLDL-stimulated HUVECs and the plaque endothelium of apoE-/- mice. Additionally, both of them restricted atherosclerosis development of apoE-/- mice. Mechanistic studies showed that oxLDL-induced the increase in ROS production, phosphorylation of ERK and nuclear translocation of NF-κB in HUVECs was si...
Source: Molecules - March 19, 2022 Category: Chemistry Authors: Ning Meng Kai Chen Yanhong Wang Jiarong Hou Wenhui Chu Shan Xie Fengying Yang Chunhui Sun Tags: Article Source Type: research

Molecules, Vol. 26, Pages 4919: The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
In this study, human bladder cancer T24 cells were used as in vitro model for revealing the inhibitory effect and its potential mechanism of SFN on cell growth. Here, a low dose of SFN (2.5 µM) was shown to promote cell proliferation (5.18–11.84%) and migration in T24 cells, whilst high doses of SFN (>10 µM) inhibited cell growth significantly. The induction effect of SFN on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression at both low (2.5 µM) and high dose (10 µM) was characterized by a bell-shaped curve. Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24...
Source: Molecules - August 13, 2021 Category: Chemistry Authors: Canxia He Luigina P. Buongiorno Wei Wang Jonathan C. Y. Tang Natalizia Miceli Maria Fernanda Taviano Yujuan Shan Yongping Bao Tags: Article Source Type: research

Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O- β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway Molecules doi: 10.3390/molecules26133852 Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Astragalus membranaceus is a famous herb found among medicinal and food plants in East and Southeastern Asia. The Nrf2-ARE assay-guided separation of an extract from Jing liqueur led to the identification of a nontoxic Nrf2 activator, methylnissolin-3-O-β-D-glucopyranoside (MNG, a component of A. ...
Source: Molecules - June 24, 2021 Category: Chemistry Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Tags: Article Source Type: research

Correction: A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation. Additions and Corrections
VOLUME 289 (2014) PAGES 3126–3137There was an error in Fig 6C. The dot plot in panel 1 (Control siRNA + Vector) was mistakenly duplicated with the dot plot in panel 4 (Bach-1 siRNA + CXCR3-B). However, the numbers of the % apoptotic cells were correct. This error happened inadvertently during the preparation of the figure panels. This error has now been corrected and does not affect the results or conclusions of the work reported in this study. The authors apologize for this error.jbc;295/30/10509/F6F1F6Figure 6.
Source: Journal of Biological Chemistry - July 23, 2020 Category: Chemistry Authors: Murugabaskar Balan, Soumitro Pal Tags: Additions and Corrections Source Type: research

AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride.
In conclusion, these data demonstrated for the first time that Nrf2 activation exerts a neuroprotective effect on NaF-stimulated redox imbalance and inflammation that is dependent on the AMPK/p38 pathway. PMID: 31837563 [PubMed - indexed for MEDLINE]
Source: Chemosphere - March 20, 2020 Category: Chemistry Authors: Song C, Heping H, Shen Y, Jin S, Li D, Zhang A, Ren X, Wang K, Zhang L, Wang J, Shi D Tags: Chemosphere Source Type: research

Molecules, Vol. 25, Pages 1320: Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells
Blough Ahn Evodiamine (EVO) is an indoloquinazoline alkaloid that exerts its various anti-oncogenic actions by blocking phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), mitogen-activated protein kinase (MAPK), c-Met, and nuclear factor kappa B (NF-B) signaling pathways, thus leading to apoptosis of tumor cells. We investigated the ability of EVO to affect hepatocyte growth factor (HGF)-induced c-Met/Src/STAT3 activation cascades in castration-resistant prostate cancer (CRPC). First, we noted that EVO showed cytotoxicity and anti-proliferation activities in PC-3 and DU145 cells. Next, we found that EVO m...
Source: Molecules - March 12, 2020 Category: Chemistry Authors: Hwang Um Chinnathambi Alharbi Narula Namjoshi Blough Ahn Tags: Article Source Type: research

Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase C{delta}-4 (PLC{delta}4) Cell Biology
Calcium (Ca2+) signaling within the cell nucleus regulates specific cellular events such as gene transcription and cell proliferation. Nuclear and cytosolic Ca2+ levels can be independently regulated, and nuclear translocation of receptor tyrosine kinases (RTKs) is one way to locally activate signaling cascades within the nucleus. Nuclear RTKs, including the epidermal growth factor receptor (EGFR), are important for processes such as transcriptional regulation, DNA-damage repair, and cancer therapy resistance. RTKs can hydrolyze phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) within the nucleus, leading to Ca2+ release f...
Source: Journal of Biological Chemistry - November 7, 2019 Category: Chemistry Authors: Marcelo Coutinho de Miranda, Michele Angela Rodrigues, Ana Carolina de Angelis Campos, Jerusa Arauȷo Quintao Arantes Faria, Marianna Kunrath–Lima, Gregory A. Mignery, Deborah Schechtman, Alfredo Miranda Goes, Michael H. Nathanson, Dawidson A. Tags: Signal Transduction Source Type: research

Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia Immunology
Large-conductance calcium-activated potassium (BK) channels are ubiquitously expressed in most cell types where they regulate many cellular, organ, and organismal functions. Although BK currents have been recorded specifically in activated murine and human microglia, it is not yet clear whether and how the function of this channel is related to microglia activation. Here, using patch-clamping, Griess reaction, ELISA, immunocytochemistry, and immunoblotting approaches, we show that specific inhibition of the BK channel with paxilline (10 μm) or siRNA-mediated knockdown of its expression significantly suppresses lipopolysac...
Source: Journal of Biological Chemistry - August 29, 2019 Category: Chemistry Authors: Xiaoying Yang, Guiqin Wang, Ting Cao, Li Zhang, Yunzhi Ma, Shuhui Jiang, Xinchen Teng, Xiaohui Sun Tags: Neurobiology Source Type: research

Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor Signal Transduction
The androgen receptor (AR) is often activated in prostate cancer patients undergoing androgen-ablative therapy because of the activation of cellular pathways that stimulate the AR despite low androgen levels. In many of these tumors, the cAMP-dependent protein kinase A (PKA) pathway is activated. Previous studies have shown that PKA can synergize with low levels of androgen to enhance androgen signaling and consequent cell proliferation, leading to castration-resistant prostate cancer. However, the mechanism by which PKA causes AR stimulation in the presence of low/no androgen is not established yet. Here, using immunofluo...
Source: Journal of Biological Chemistry - May 30, 2019 Category: Chemistry Authors: Manisha Dagar, Julie Pratibha Singh, Gunjan Dagar, Rakesh K. Tyagi, Gargi Bagchi Tags: Editors ' Picks Source Type: research

Molecules, Vol. 24, Pages 1377: Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3 β in MPP+-Induced Cell Damage
Molecules, Vol. 24, Pages 1377: Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3β in MPP+-Induced Cell Damage Molecules doi: 10.3390/molecules24071377 Authors: Armagan Sevgili Gürkan Köse Bilgiç Dagcı Saso Recently, nuclear translocation and stability of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) have gained increasing attention in the prevention of oxidative stress. The present study was aimed to evaluate the regulatory role of glycogen synthase kinase-3β (GSK-3β) inhibition by tideglusib through the Nrf2 pathway in a cellular damage mod...
Source: Molecules - April 7, 2019 Category: Chemistry Authors: Armagan Sevgili G ürkan K öse Bilgi ç Dagc ı Saso Tags: Article Source Type: research