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Specialty: Reproduction Medicine
Condition: Infertility
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Total 29 results found since Jan 2013.
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway
CONCLUSIONS: These findings suggest that SIRT1 pathway plays essential roles in the pleiotropic actions of melatonin on Leydig cells and in the prevention of hyperglycaemia-induced steroidogenic dysfunction. The stimulatory action of melatonin on SIRT1 pathway is related to oxidative stress and its antioxidant property. Our data provide new evidence for the relationship of melatonin and SIRT1 pathway in the context of hyperglycaemia, and melatonin as a combination therapy may be useful to combat DM-related complications, especially male reproductive system injury.PMID:35962432 | DOI:10.1186/s12958-022-00991-6
Source: Reproductive Biology - August 12, 2022 Category: Reproduction Medicine Authors: Ping Wang Shoubing Zhang Shuai Lin Zhengmei Lv Source Type: research
Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes
Syst Biol Reprod Med. 2022 Mar 30:1-14. doi: 10.1080/19396368.2022.2033350. Online ahead of print.ABSTRACTDiabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play a pivotal role in male reproductive function. In the current study, we investigated the relationship between AQPs and testicular steroidogenesis under hyperglycemia in vivo and in vitro. The effect of high glucose on the role of AQPs in Leydi...
Source: Systems Biology in Reproductive Medicine - March 30, 2022 Category: Reproduction Medicine Authors: Arun Kannan Lezy Flora Mariajoseph-Antony Antojenifer Panneerselvam Chithra Loganathan Diwakar Kiduva Jothiraman Kumarasamy Anbarasu Chidambaram Prahalathan Source Type: research
Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells
CONCLUSIONS: This study increases the understanding of the biological function of GDF-11 and provides important insights into the regulation of ovarian steroidogenesis.PMID:35183204 | DOI:10.1186/s12958-022-00912-7
Source: Reproductive Biology - February 20, 2022 Category: Reproduction Medicine Authors: Qiongqiong Jia Boqun Liu Xuan Dang Yanjie Guo Xiaoyu Han Tinglin Song Jung-Chien Cheng Lanlan Fang Source Type: research
Protective role of Cytoglobin and Neuroglobin against the Lipopolysaccharide (LPS)-induced inflammation in Leydig cells ex vivo
Reprod Biol. 2022 Feb 1;22(1):100595. doi: 10.1016/j.repbio.2021.100595. Online ahead of print.ABSTRACTLeydig cells are responsible for testosterone production in male testis upon stimulation by luteinizing hormone. Inflammation and oxidative stress related Leydig cell dysfunction is one of the major causes of male infertility. Cytoglobin (CYGB) and Neuroglobin (NGB) are two globin family member proteins which protect cells against oxidative stress. In the current study, we established a Lipopolysaccharide (LPS)-induced inflammation model in TM3 Leydig cell culture to study the function of CYGB and NGB proteins under infla...
Source: Reproductive Biology - February 5, 2022 Category: Reproduction Medicine Authors: Derya Sa ğraç Selinay Şenkal Taha Bartu Hayal Selami Demirci Hatice Burcu Şişli Ayla Bur çin Asutay Ay şegül Doğan Source Type: research
Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis
CONCLUSIONS: The testicular zinc transporter ZIP12 expression levels especially in spermatogonia and spermatozoa are higher than in other tissues. ZIP12 may play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis which help counteract declines in male fertility.PMID:35065654 | PMC:PMC8783530 | DOI:10.1186/s12958-022-00893-7
Source: Reproductive Biology - January 23, 2022 Category: Reproduction Medicine Authors: Xinye Zhu Chengxuan Yu Wangshu Wu Lei Shi Chenyi Jiang Li Wang Zhide Ding Yue Liu Source Type: research
Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity.
CONCLUSION: Together, our data revealed that CDH6 was dysregulated in the endometrium from women with infertility and altered Ishikawa cell adhesive capacity. Our study supports a role for CDH6 in regulating endometrial adhesion and implantation.
PMID: 32600462 [PubMed - in process]
Source: Reproductive Biology - June 28, 2020 Category: Reproduction Medicine Authors: Zhou W, Santos L, Dimitriadis E Tags: Reprod Biol Endocrinol Source Type: research
Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development
ConclusionsThese results suggest that mouseNlrp9b, as a maternal effect gene, could contribute to mouse preimplantation embryo development. It remains to investigate whether NLRP9 have a crucial role in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - May 11, 2020 Category: Reproduction Medicine Source Type: research
FoxO transcription factors 1 regulate mouse preimplantation embryo development
ConclusionsThese results suggest that FOXO transcription factors could contribute to mouse preimplantation embryo development, and it remains to investigate whether they have crucial roles in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - August 7, 2019 Category: Reproduction Medicine Source Type: research
Low MFN2 expression related to ageing in granulosa cells is associated with assisted reproductive technology outcome
ConclusionsLow MFN2 expression levels in granulosa cells were related to ageing, which may be involved in the clinical outcome of ART by promoting cell apoptosis and affecting mitochondrial function.
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research
