Filtered By:
Specialty: Anesthesiology

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 40 results found since Jan 2013.

The time-course and RNA interference of TNF-α, IL-6, and IL-1β expression on neuropathic pain induced by L5 spinal nerve transection in rats.
CONCLUSIONS: The time courses of TNF-α, IL-6 and IL-1β mRNA expression after L5 SNT differ. RNA interference may be a method of reducing the development of mechanical allodynia and hyperalgesia in response to nerve injury. PMID: 25844135 [PubMed]
Source: Korean Journal of Anesthesiology - November 18, 2015 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

Therapeutic potential of RNA interference in pain medicine.
Authors: Tan PH, Yang LC, Ji RR Abstract In recent years RNA interference (RNAi) has rapidly become the most widely used tool for gene knockdown due to its high specificity and potency. RNAi is an evolutionarily conserved mechanism for silencing gene expression by targeted degradation of mRNA. In the past decade, hundreds of molecular targets have been identified for their roles in pain modulation. But most molecular targets are not readily druggable with small molecules. RNAi represents a therapeutic approach applicable to these non-druggable targets. There is a rapid increase in the number of studies that use sma...
Source: Open Pain Journal - June 4, 2015 Category: Anesthesiology Tags: Open Pain J Source Type: research

Isoflurane but Not Sevoflurane or Desflurane Aggravates Injury to Neurons In Vitro and In Vivo via p75NTR-NF-ĸB Activation.
CONCLUSIONS:: Isoflurane but not sevoflurane or desflurane postexposure aggravates neurotoxicity in preinjured neurons via activation of p75 and NF-κB. These findings may have implications for the choice of volatile anesthetic being used in patients with or at risk for neuronal injury, specifically in patients with a stroke or history of stroke and in surgical procedures in which neuronal injury is likely to occur, such as cardiac surgery and neurovascular interventions. PMID: 25329094 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - October 17, 2014 Category: Anesthesiology Authors: Schallner N, Ulbrich F, Engelstaedter H, Biermann J, Auwaerter V, Loop T, Goebel U Tags: Anesth Analg Source Type: research

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling
In this study, we investigated the role of TRAF6 in neuropathic pain in mice after spinal nerve ligation (SNL). SNL induced persistent TRAF6 upregulation in the spinal cord. Interestingly, TRAF6 was mainly colocalized with the astrocytic marker glial fibrillary acidic protein on SNL day 10 and partially expressed in microglia on SNL day 3. In cultured astrocytes, TRAF6 was upregulated after exposure to TNF-α or IL-1β. TNF-α or IL-1β also increased CCL2 expression, which was suppressed by both siRNA and shRNA targeting TRAF6. TRAF6 siRNA treatment also inhibited the phosphorylation of c-Jun N-terminal kinase (JNK) in as...
Source: Pain - September 29, 2014 Category: Anesthesiology Authors: Ying Lu, Bao-Chun Jiang, De-Li Cao, Zhi-Jun Zhang, Xin Zhang, Ru-Rong Ji, Yong-Jing Gao Tags: Research papers Source Type: research

NRG1‐ErbB signalling promotes microglia activation contributing to incision‐induced mechanical allodynia
ConclusionIncision‐induced NRG1 expression mediated activation of dorsal horn microglia and contributed to the development of mechanical allodynia. Specifically targeting NRG1‐ErbB signalling may therefore provide a new therapeutic intervention for relieving incision‐induced mechanical allodynia.
Source: European Journal of Pain - August 27, 2014 Category: Anesthesiology Authors: Y. Xiang, T. Liu, H. Yang, F. Gao, H. Xiang, A. Manyande, Y. Tian, X. Tian Tags: Original Article Source Type: research

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain
Summary: Our research suggests that MrgC agonism at spinal sites constitutes a novel pain inhibitory mechanism in rodent models of neuropathic pain.Abstract: Chronic neuropathic pain is often refractory to current pharmacotherapies. The rodent Mas-related G-protein-coupled receptor subtype C (MrgC) shares substantial homogeneity with its human homologue, MrgX1, and is located specifically in small-diameter dorsal root ganglion neurons. However, evidence regarding the role of MrgC in chronic pain conditions has been disparate and inconsistent. Accordingly, the therapeutic value of MrgX1 as a target for pain treatment in hum...
Source: Pain - December 12, 2013 Category: Anesthesiology Authors: Shao-Qiu He, Zhe Li, Yu-Xia Chu, Liang Han, Qian Xu, Man Li, Fei Yang, Qin Liu, Zongxiang Tang, Yun Wang, Niyada Hin, Takashi Tsukamoto, Barbara Slusher, Vinod Tiwari, Ronen Shechter, Feng Wei, Srinivasa N. Raja, Xinzhong Dong, Yun Guan Tags: Research papers Source Type: research

Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain
Summary: Modified expression and function of the adhesion molecule neuroligin 2 are involved in the excitation/inhibition imbalance leading to the dorsal horn network’s hyperexcitability in neuropathic rats.Abstract: In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and inhibitory synapses, respectively. In the dorsal horn of SNL rats, NL2 was overexpressed whe...
Source: Pain - July 29, 2013 Category: Anesthesiology Authors: Tiphaine Dolique, Alexandre Favereaux, Olivier Roca-Lapirot, Virginie Roques, Claire Léger, Marc Landry, Frédéric Nagy Tags: Research papers Source Type: research

Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors
TOC summary: Gelsemine produces potent and specific antinociception in chronic pain states by activating spinal α3 glycine receptors without inducing tolerance.Abstract: The present study examined the antinociceptive effects of gelsemine, the principal alkaloid in Gelsemium sempervirens Ait. A single intrathecal injection of gelsemine produced potent and specific antinociception in formalin-induced tonic pain, bone cancer-induced mechanical allodynia, and spinal nerve ligation-induced painful neuropathy. The antinociception was dose-dependent, with maximal inhibition of 50% to 60% and ED50 values of 0.5 to 0.6μg. Multipl...
Source: Pain - July 24, 2013 Category: Anesthesiology Authors: Jing-Yang Zhang, Nian Gong, Jin-Lu Huang, Ling-Chen Guo, Yong-Xiang Wang Tags: Research papers Source Type: research

Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons
Summary: Membrane-bound tumor necrosis factor-α, acting through tumor necrosis factor receptor 2, causes increased expression in dorsal root ganglia of genes whose products are implicated in heightened neuronal excitability characteristic of chronic neuropathic pain.Abstract: Neuropathic pain resulting from spinal hemisection or selective spinal nerve ligation is characterized by an increase in membrane-bound tumor necrosis factor-alpha (mTNFα) in spinal microglia without detectable release of soluble TNFα (sTNFα). In tissue culture, we showed that a full-length transmembrane cleavage-resistant TNFα (CRTNFα) construc...
Source: Pain - May 28, 2013 Category: Anesthesiology Authors: Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J. Fink Tags: Research papers Source Type: research

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia
Summary: Knocking down expression of the sodium channel isoform NaV1.6 in lumbar sensory ganglia blocked development of pain behaviors and neuronal hyperexcitability induced by local inflammation of the ganglion.Abstract: Inflammatory processes in the sensory ganglia contribute to many forms of chronic pain. We previously showed that local inflammation of the lumbar sensory ganglia rapidly leads to prolonged mechanical pain behaviors and high levels of spontaneous bursting activity in myelinated cells. Abnormal spontaneous activity of sensory neurons occurs early in many preclinical pain models and initiates many other pat...
Source: Pain - March 7, 2013 Category: Anesthesiology Authors: Wenrui Xie, Judith A. Strong, Ling Ye, Ju-Xian Mao, Jun-Ming Zhang Tags: Research papers Source Type: research