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The contrasting roles of Dysferlin during tumor progression in renal cell carcinoma.
CONCLUSION: DYSF mRNA and protein expression are opposingly involved in tumor progression of ccRCC. DYSF could be used as a prognostic biomarker to predict survival of patients with ccRCC. PMID: 32430251 [PubMed - as supplied by publisher]
Source: Urologic Oncology - May 16, 2020 Category: Urology & Nephrology Authors: Cox A, Zhao C, Tolkach Y, Nettersheim D, Schmidt D, Kristiansen G, Hauser S, Müller SC, Ritter M, Ellinger J Tags: Urol Oncol Source Type: research

Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/Cyclin E.
In conclusion, Gsa is required for tubular epithelial cell regeneration during kidney repair after AKI. The loss of Gsa impairs renal tubular epithelial cell regeneration by blocking the Raf-MEK-ERK pathway. PMID: 32036696 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - February 9, 2020 Category: Urology & Nephrology Authors: Liu L, Deng Y, Cai Y, Lu P, Guo Y, Zhang C, Li Q, Zhang T, Han M, Xu G Tags: Am J Physiol Renal Physiol Source Type: research

KDM1A triggers androgen‐induced miRNA transcription via H3K4me2 demethylation and DNA oxidation
ConclusionOur work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen‐dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - March 2, 2015 Category: Urology & Nephrology Authors: Shu Yang, Jiyuan Zhang, Yalong Zhang, Xuechao Wan, Congzhe Zhang, Xiaohui Huang, Wenhua Huang, Honglei Pu, Chaohan Pei, Hai Wu, Yan Huang, Shengdong Huang, Yao Li Tags: Original Article Source Type: research

A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress
CONCLUSIONSThe data suggest that WJ25591 inhibited HDAC activity, leading to cell‐cycle arrest and inhibition of DNA repair. Caspase cascades are subsequently triggered to execute cell apoptosis. MG‐132 dramatically sensitizes WJ25591‐mediated apoptosis, at least partly, through ER stress response. The data also reveal that combination of HDAC inhibitors and proteasome inhibitors may be a potential strategy against hormone‐refractory prostate cancers. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 28, 2013 Category: Urology & Nephrology Authors: Yi‐Cheng Chen, Wei‐Jan Huang, Jui‐Ling Hsu, Chia‐Chun Yu, Wei‐Ting Wang, Jih‐Hwa Guh Tags: Original Article Source Type: research