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Development of a Hybrid Cryogel-Coated Prosthetic Vascular Graft for Delivery of Targeted Gene Therapies
Anastomotic neointimal hyperplasia remains a limiting factor in the long-term success of prosthetic vascular grafts. Understanding of the molecular mechanisms involved in the host response to prosthetic material has set the stage for using this material to deliver small interfering RNA (siRNA) and other modulators of the anastomotic neointimal hyperplasia-associated transcriptome response, along with antithrombotic agents. To create practical and effective drug delivery from a prosthetic material, we have combined a platform of polyethylene terephthalate (PET) fabric with an applied cryogel carrying the biologic agents, re...
Source: Journal of Vascular Surgery - August 23, 2016 Category: Surgery Authors: Cindy Huynh, Ting-Yu Shih, Amruta Samant, Saif G. Pathan, David W. Nelson, David J. Mooney, Leena Pradhan-Nabzdyk, Frank W. LoGerfo Tags: Abstract from the 2016 Eastern Vascular Society Annual Meeting Source Type: research

Acellular dermal matrix-based gene therapy augments graft incorporation
Acellular dermal matrix (ADM) is widely used for structural or dermal replacement purposes. Given its innate biocompatibility and its potential to vascularize, we explored the possibility of ADM to function as a small interfering RNA (siRNA) delivery system. Specifically, we sought to improve ADM vascularization by siRNA-mediated inhibition of prolyl hydroxylase domain-2 (PHD2), a cytoplasmic protein that regulates hypoxia inducible factor-1α, and improve neovascularization.
Source: Journal of Surgical Research - January 30, 2015 Category: Surgery Authors: Meredith T. Vandegrift, Caroline Spzalski, Denis Knobel, Andrew Weinstein, Maria Ham, Obinna Ezeamuzie, Stephen M. Warren, Pierre B. Saadeh Source Type: research