Development of a Hybrid Cryogel-Coated Prosthetic Vascular Graft for Delivery of Targeted Gene Therapies

Anastomotic neointimal hyperplasia remains a limiting factor in the long-term success of prosthetic vascular grafts. Understanding of the molecular mechanisms involved in the host response to prosthetic material has set the stage for using this material to deliver small interfering RNA (siRNA) and other modulators of the anastomotic neointimal hyperplasia-associated transcriptome response, along with antithrombotic agents. To create practical and effective drug delivery from a prosthetic material, we have combined a platform of polyethylene terephthalate (PET) fabric with an applied cryogel carrying the biologic agents, resulting in a bioactive prosthetic graft system.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2016 Eastern Vascular Society Annual Meeting Source Type: research