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Silencing the livin gene enhances the cytotoxic effects of anticancer drugs on colon cancer cells.
CONCLUSION: siRNA-mediated down-regulation of livin gene expression could significantly suppress colon cancer growth and enhance the cytotoxic effects of anticancer drugs such as 5-FU and L-OHP. The results of this study suggest that silencing livin gene expression in combination with treatment with anticancer drugs might be a novel cancer therapy for colorectal cancer. PMID: 27904848 [PubMed - in process]
Source: Annals of Surgical Treatment and Research - December 3, 2016 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
Conclusion: These data might be used along with other markers to predict response to radiation in patients with rectal cancer.
Source: Surgery - August 1, 2013 Category: Surgery Authors: Sergio Huerta, Xiaohuan Gao, Sean Dineen, Payal Kapur, Debrabata Saha, Jeffrey Meyer Tags: Society of University Surgeons Source Type: research

Murine portal vein catheterization to analyze liver-directed therapies
Conclusions: Liver-directed therapy can provide the selective delivery of siRNA to CRC metastases. EpCAM expression in CRC, but not normal liver, could further selectively target hepatic metastases of epithelial origin.
Source: Journal of Surgical Research - July 18, 2013 Category: Surgery Authors: Joseph D. Valentino, Piotr G. Rychahou, W. Conan Mustain, Victoria A. Elliott, B. Mark Evers Tags: Oncology/Endocrine Source Type: research

Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth
Conclusions: Silencing GRP78 not only inhibits tumor, but also decreases the expression of VEGF and VEGFR2. Collectively, therapy targeting for GRP78 may inhibit the formation of colon cancer tumors via the HIF-1α/VEGF/VEGFR2 pathway.
Source: Journal of Surgical Research - May 30, 2013 Category: Surgery Authors: Li-Jen Kuo, Chin-Sheng Hung, Wei-Yu Chen, Yu-Jia Chang, Po-Li Wei Tags: Oncology/Endocrine Source Type: research

Therapeutic Implications of MSC-mediated Delivery of SiRNA Via Gap Junctions in the Treatment of Colon Cancer
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K. Chang, S. Kosari, J. Karas, T. Gregg, P. Brink, R. Bergamaschi Tags: Quickshot Session: Thursday 2/7 3:30 PM to 5:30 PM Source Type: research