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Cancer combination therapies by silencing of CTLA ‐4, PD‐L1, and TIM3 in osteosarcoma
ConclusionOur findings suggest that triple blockade of CTLA-4, PD-L1, and TIM3 is an effective strategy for inhibiting tumor cell progression and migration in OS, which requires large-scale clinical investigations to be translated into broad therapeutic applicability for OS patients.
Source: IUBMB Life - May 31, 2022 Category: Research Authors: Amin Daei Sorkhabi, Aila Sarkesh, Ali Fotouhi, Hossein Saeedi, Leili Aghebati ‐Maleki Tags: RESEARCH COMMUNICATION Source Type: research

Role of Exosomes and its emerging therapeutic applications in the pathophysiology of Non-Infectious disease
Biomarkers. 2022 Apr 22:1-53. doi: 10.1080/1354750X.2022.2067233. Online ahead of print.ABSTRACTExosomes are a type of small Extracellular Vesicles (EVs) and play crucial roles in cancer and other diseases. Exosomes role in various diseases has been studied as they regulate intercellular communication and are obtained from almost any part of the body. Exosomes use is complicated in diseases as they promote pathogenesis but also act as a very good therapeutic agent in most diseases. The presence of a complex molecular cargo consisting of nucleic acids (DNA, RNA, miRNA, siRNA, etc.,) makes it a very good delivery agent and a...
Source: Biomarkers - April 22, 2022 Category: Research Authors: Gauresh Gurudas Shivji Rajib Dhar Arikketh Devi Source Type: research

Lipidoid nanoparticle mediated silencing of Mcl-1 induces apoptosis in mantle cell lymphoma
In this study, we use potent lipidoid nanoparticles to deliver siRNA to silence Mcl-1 expression. Studies were conducted using two different mantle cell lymphoma cell lines, a normal (JeKo-1) and an aggressive (MAVER-1) line, to assess the ability of lipidoid nanoparticles to be used broadly in the treatment of mantle cell lymphoma. Mcl-1 mRNA silencing and protein knockdown was observed as early as one day after treatment and the lipidoid nanoparticles achieved sustained silencing of Mcl-1 mRNA for at least four days in both JeKo-1 and MAVER-1 cells. Eighty percent silencing was achieved at three days post-transfection in...
Source: Experimental Biology and Medicine - May 12, 2016 Category: Research Authors: Knapp, C. M., He, J., Lister, J., Whitehead, K. A. Tags: Original Research Source Type: research

Silencing c-Kit expression in human DCs suppresses Th2, Th17 response but enhances Th1 response.
Authors: Yang B, Yang Q, Huang Q, Yan H, Sun T, Tong H Abstract Dendritic cells (DCs) are integral to the differentiation of T helper cells into T helper type 1 TH1, TH2 and TH17 subsets. RNA interference (RNAi), which causes the degradation of any RNA in a sequence specific manner, is a posttranscriptional gene silencing mechanism. Targeting the c-Kit in DCs has been used as an approach to enhance antitumor immunity. Here, we shwed that transfection of DCs with siRNA specific for c-Kit gene can significantly knock down c-Kit. When exposed to TNF-α, immature DCs transfected with c-Kit siRNA can differentiate into ...
Source: American Journal of Translational Research - November 11, 2015 Category: Research Tags: Am J Transl Res Source Type: research