Filtered By:
Specialty: Pathology
Cancer: Adenocarcinoma

This page shows you your search results in order of date.

Order by Relevance | Date

Total 22 results found since Jan 2013.

Expression of kinesin family member C1 in pancreatic ductal adenocarcinoma affects tumor progression and stemness
This study aimed to analyze the expression and biological function of KIFC1 in PDAC. Immunohistochemically, KIFC1 was found in 37 of 81 PDAC cases (46%). A high expression of KIFC1 was significantly related to tumor size (p = 0.023) and poor overall survival (p = 0.011). Univariate and multivariate analysis indicated that KIFC1 expression was a prognostic factor in PDAC cases. As for cancer stem cell markers, KIFC1 expression tended to co-express significantly with CD44 (p < 0.01). The growth and spheroid colony formation of KIFC1 small interfering RNA (siRNA)-transfected PDAC cells were significantly lower than those o...
Source: Pathology, Research and Practice - December 24, 2022 Category: Pathology Authors: Akira Ishikawa Hiroki Fujii Takafumi Fukui Aya Kido Narutaka Katsuya Kazuhiro Sentani Kazuya Kuraoka Sho Tazuma Takeshi Sudo Masahiro Serikawa Shiro Oka Naohide Oue Source Type: research

KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.
CONCLUSION: KIAA1429 exhibited an unusually high expression in LUAD cells and tissues, and high KIAA1429 expression was correlated with the clinical and pathological features of patients with LUAD, thereby leading to an unsatisfactory prognosis. Furthermore, KIAA1429 regulates MUC3A expression through m6A modification to modulate LUAD cells to proliferate, migrate, invade, and induce cell cycle arrest. PMID: 33249400 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - November 12, 2020 Category: Pathology Authors: Zhao W, Xie Y Tags: Pathol Res Pract Source Type: research

miR-499a promotes PANC-1 cell proliferation by down-regulating PDCD4 expression in pancreatic ductal adenocarcinoma.
In conclusion, we first found miR-499a was significantly up-regulated in PDAC tissues, and we promoted PANC-1 cell proliferation by down-regulating PDCD4 expression. PMID: 32661474 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - July 16, 2020 Category: Pathology Authors: Bao J, Li Z Tags: Int J Clin Exp Pathol Source Type: research

The membrane protein sortilin can be targeted to inhibit pancreatic cancer cell invasion.
In this study, we found that sortilin expression was higher in pancreatic cell lines vs normal pancreatic ductal epithelial cells, as demonstrated by Western blot and mass spectrometry. The increased sortilin level in pancreatic cancer cells was confirmed by immunohistochemistry in a series of 99 human pancreatic adenocarcinomas vs 48 normal pancreatic tissues (p=0.0014). Sortilin inhibition by siRNA and the pharmacological inhibitor AF38469 strongly reduced the adhesion and invasion of pancreatic cancer cells without affecting cell survival and viability. Sortilin inhibition also decreased the phosphorylation of the focal...
Source: The American Journal of Pathology - June 7, 2020 Category: Pathology Authors: Gao F, Griffin N, Faulkner S, Li X, King SJ, Jobling P, Denham JW, Jiang CC, Hondermarck H Tags: Am J Pathol Source Type: research

Long non-coding RNA MALAT1 aggravates human retinoblastoma by sponging miR-20b-5p to upregulate STAT3.
CONCLUSION: MALAT1 could increase proliferation and reduce apoptosis by sponging miR-20b-5p to upregulate STAT3 in RB cells. Therefore, MALAT1 might be a latent target in the RB treatment. PMID: 32336590 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - April 17, 2020 Category: Pathology Authors: Wang L, Zhang Y, Xin X Tags: Pathol Res Pract Source Type: research

Tumor-promoting activity of long non-coding RNA LINC00466 in lung adenocarcinoma via microRNA-144 –regulated HOXA10 axis
Previous investigations have implicated long non-coding RNAs (lncRNAs) in lung adenocarcinoma, which is an aggressive disease with poor prognosis and high mortality. Through the alteration of lung adenocarcinoma –related lncRNA and microRNA (miRNA) based on microarray analysis, our aim was to understand that the role of LINC00466 and miR-144 in lung adenocarcinoma progression. The relationship among LINC00466, miR-144, and HOXA10 was also verified. Moreover, to examine whether the LINC00466/miR-144/HOXA10 axis contributed to the cellular processes in lung adenocarcinoma, A549 and XWLC-05 cells were transduced with siRNA ...
Source: American Journal of Pathology - August 1, 2019 Category: Pathology Authors: Tiangang Ma, Yanbing Hu, Yingxue Guo, Bingdi Yan Source Type: research

Tumor-promoting activity of long non-coding RNA LINC00466 in lung adenocarcinoma via microRNA-144-regulated HOXA10 axis.
Abstract Previous investigations have implicated long non-coding RNAs (lncRNAs) in lung adenocarcinoma, which is an aggressive disease with poor prognosis and high mortality. Through the alteration of lung adenocarcinoma-related lncRNA and microRNA (miRNA) based on microarray analysis, our aim was to understand that the role of LINC00466 and miR-144 in lung adenocarcinoma progression. The relationship among LINC00466, miR-144, and HOXA10 was also verified. Moreover, to examine whether the LINC00466/miR-144/HOXA10 axis contributed to the cellular processes in lung adenocarcinoma, A549 and XWLC-05 cells were transdu...
Source: The American Journal of Pathology - August 1, 2019 Category: Pathology Authors: Ma T, Hu Y, Guo Y, Yan B Tags: Am J Pathol Source Type: research

Tumor-Promoting Activity of Long Noncoding RNA LINC00466 in Lung Adenocarcinoma via miR-144 –Regulated HOXA10 Axis
Previous investigations have implicated long noncoding RNAs in lung adenocarcinoma, which is an aggressive disease with poor prognosis and high mortality. Through the alteration of lung adenocarcinoma –related long noncoding RNA and miRNA based on microarray analysis, our aim was to understand the role of LINC00466 and miR-144 in lung adenocarcinoma progression. The relationship among LINC00466, miR-144, and HOXA10 was also verified. Moreover, to examine whether the LINC00466/miR-144/HOXA10 axi s contributed to the cellular processes in lung adenocarcinoma, A549 and XWLC-05 cells were transduced with siRNA LINC00466, siR...
Source: American Journal of Pathology - August 1, 2019 Category: Pathology Authors: Tiangang Ma, Yanbing Hu, Yingxue Guo, Bingdi Yan Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation,invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - November 19, 2017 Category: Pathology Source Type: research

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer
Abstract Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition, and a catalytic reverse transcriptase (TERT). While expression of TERT has been considered the key rate limiting component for telomerase activity, increasing evidence suggests an important role for the regulation of TERC in telomere maintenance and perhaps other functions in human cancer. By using three orthogonal methods including RNAseq, RT‐qPCR, and an analytically validated chromogenic RNA in situ hybridization assay, we report consistent overexpression of TERC in prosta...
Source: The Journal of Pathology - September 9, 2017 Category: Pathology Authors: Javier A Baena ‐Del Valle, Qizhi Zheng, David M Esopi, Michael Rubenstein, Gretchen K Hubbard, Maria C Moncaliano, Andrew Hruszkewycz, Ajay Vaghasia, Srinivasan Yegnasubramanian, Sarah J Wheelan, Alan K Meeker, Christopher M Heaphy, Mindy K Graham, Ange Tags: Original Paper Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma.
Abstract Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or western blot assay was performed to analyze FOXP3 expression in A549 cells. Cell proliferation and cisplatin cytotoxicity test were assessed by CCK-8 assay. The expression...
Source: Pathology, Research and Practice - September 8, 2017 Category: Pathology Authors: Li C, Sun L, Jiang R, Wang P, Xue H, Zhan Y, Gai X Tags: Pathol Res Pract Source Type: research

Forkhead box protein A2, a pioneer factor for hepatogenesis, is involved in the expression of hepatic phenotype of alpha-fetoprotein-producing adenocarcinoma
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nobuhisa Yamamura, Kazunori Fugo, Takashi Kishimoto Alpha-fetoprotein (AFP)-producing adenocarcinoma is a high-malignant variant of adenocarcinoma with a hepatic or fetal-intestinal phenotype. The number of cases of AFP-producing adenocarcinomas is increasing, but the molecular mechanism underlying the aberrant production of AFP is unclear. Here we sought to assess the role of Forkhead box A (FoxA)2, which is a pioneer transcription factor in the differentiation of hepatoblasts. FoxA2 expression was investigated in five cas...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Forkhead box protein A2, a pioneer factor for hepatogenesis, is involved in the expression of hepatic phenotype of alpha-fetoprotein-producing adenocarcinoma.
Abstract Alpha-fetoprotein (AFP)-producing adenocarcinoma is a high-malignant variant of adenocarcinoma with a hepatic or fetal-intestinal phenotype. The number of cases of AFP-producing adenocarcinomas is increasing, but the molecular mechanism underlying the aberrant production of AFP is unclear. Here we sought to assess the role of Forkhead box A (FoxA)2, which is a pioneer transcription factor in the differentiation of hepatoblasts. FoxA2 expression was investigated in five cases of AFP-producing gastric adenocarcinomas by immunohistochemistry, and all cases showed FoxA2 expression. Chromatin immunoprecipitati...
Source: Pathology, Research and Practice - July 23, 2017 Category: Pathology Authors: Yamamura N, Fugo K, Kishimoto T Tags: Pathol Res Pract Source Type: research