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APX-115A, a pan-NADPH oxidase inhibitor, induces caspase-dependent cell death by suppressing NOX4-ROS signaling in EBV-infected retinal epithelial cells.
Conclusion Taken together, these our results suggest that APX-115A could be a therapeutic agent for treating EBV-infected retinal cells or diseases by inhibiting LMP1-NOX4-ROS signaling. PMID: 31951764 [PubMed - as supplied by publisher]
Source: Current Eye Research - January 16, 2020 Category: Opthalmology Authors: Hong SW, Noh MH, Kim YS, Jin DH, Moon SH, Yang JW, Hur DY Tags: Curr Eye Res Source Type: research

Gene transfer to the outflow tract.
Abstract Elevated intraocular pressure is the primary cause of open angle glaucoma. Outflow resistance exists within the trabecular meshwork but also at the level of Schlemm's canal and further downstream within the outflow system. Viral vectors allow to take advantage of naturally evolved, highly efficient mechanisms of gene transfer, a process that is termed transduction. They can be produced at biosafety level 2 in the lab using protocols that have evolved considerably over the last 15-20 years. Applied by an intracameral bolus, vectors follow conventional as well as uveoscleral outflow pathways. They may affec...
Source: Experimental Eye Research - April 26, 2016 Category: Opthalmology Authors: Dang Y, Loewen R, Parikh HA, Roy P, Loewen NA Tags: Exp Eye Res Source Type: research

Herpes Virus Entry Mediator in Human Corneal Epithelial Cells Modulates the Production of Inflammatory Cytokines in Response to HSV Type 1 Challenge
Conclusions: HVEM in human corneal epithelial cells may act to dampen the production of some cytokines and chemokines and thus it may modulate the innate immune response against HSV-1. This may provide a novel mechanism for the pathogenesis of HSV-1 infection in the cornea.Ophthalmic Res 2015;54:128-134
Source: Ophthalmic Research - August 31, 2015 Category: Opthalmology Source Type: research