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Infectious Disease: Herpes

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Total 89 results found since Jan 2013.

An aging-susceptible circadian rhythm controls cutaneous antiviral immunity
JCI Insight. 2023 Sep 19:e171548. doi: 10.1172/jci.insight.171548. Online ahead of print.ABSTRACTAged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin and such circadian-control of AVPs was diminished by disruption of immune cell interleukin 27 signaling and deletion of Bmal1/Clock genes in mouse skins, as well as siRNA-mediated knockdown of CLOCK in ...
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Stephen Kirchner Vivian Lei Paul T Kim Meera Patel Jessica L Shannon David Corcoran Dalton Hughes Diana K Waters Kafui Dzirasa Detlev Erdmann J örn Coers Amanda S MacLeod Jennifer Y Zhang Source Type: research

AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
Microbiol Spectr. 2023 Sep 13:e0041723. doi: 10.1128/spectrum.00417-23. Online ahead of print.ABSTRACTHerpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damage of organs. In these conditions, HSV-1 may infect vascular endothelial cells, but little is known about the regulation of HSV-1 replication and possible defense mechanisms in these cells. The current study addresses the question of whet...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Heena Doshi Katrin Spengler Amod Godbole Yi Sing Gee Jonathan Baell Jonathan S Oakhill Andreas Henke Regine Heller Source Type: research

ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells
Viruses. 2023 Jun 27;15(7):1457. doi: 10.3390/v15071457.ABSTRACTThe strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling determines intracellular and extracellular physiological activities, including the successful infection of viruses in permissive cells, but its role in the HSV-1 life cycle is still unclear. Here, we demonstrated that the HSV-1 immediate early (IE) gene ICP4 inhibits protein kinase A (PKA) phosphorylation to induce Rap1b-activation-mediated viral infection. Rap1b activation and membrane enrichment begin at the early stage of HSV-1 infection and remain active during the prolife...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Beibei Zhang Juntao Ding Zhenghai Ma Source Type: research

Viruses, Vol. 15, Pages 1457: ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells
ai Ma The strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling determines intracellular and extracellular physiological activities, including the successful infection of viruses in permissive cells, but its role in the HSV-1 life cycle is still unclear. Here, we demonstrated that the HSV-1 immediate early (IE) gene ICP4 inhibits protein kinase A (PKA) phosphorylation to induce Rap1b-activation-mediated viral infection. Rap1b activation and membrane enrichment begin at the early stage of HSV-1 infection and remain active during the proliferation period of the virus. Treating the cells with Ra...
Source: Viruses - June 27, 2023 Category: Virology Authors: Beibei Zhang Juntao Ding Zhenghai Ma Tags: Article Source Type: research

Herpes simplex virus type I glycoprotein L evades host antiviral innate immunity by abrogating the nuclear translocation of phosphorylated NF- κB sub-unit p65
Front Microbiol. 2023 May 9;14:1178249. doi: 10.3389/fmicb.2023.1178249. eCollection 2023.ABSTRACTNuclear factor (NF)-κB plays an important role in the innate immune response by inducing antiviral genes' expression. However, the herpes simplex virus 1 (HSV-1) virus has developed multiple ways to interfere with NF-κB activity to escape the host antiviral response. Here, we found that HSV-1 envelope glycoprotein L(gL) markedly inhibits interferon (IFN) production and its downstream antiviral genes. Our results showed that ectopic expression of gL inhibited IFN-β promoter activation, and decreased IFN-β production, the ex...
Source: Herpes - May 25, 2023 Category: Infectious Diseases Authors: Zhaolong Li Zhihua Feng Zhou Fang Jianghua Chen Wengzhi Chen Wangwang Liang Qi Chen Source Type: research

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity
bioRxiv. 2023 Apr 18:2023.04.14.536934. doi: 10.1101/2023.04.14.536934. Preprint.ABSTRACTAged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin and such circadian-control of AVPs was diminished by disruption of immune cell interleukin 27 signaling and deletion of Bmal1/Clock genes in mouse skins, as well as siRNA-mediated knockdown of CLOCK in human pr...
Source: Herpes - May 3, 2023 Category: Infectious Diseases Authors: Stephen Kirchner Vivian Lei Paul Kim Meera Patel Jessica Shannon David Corcoran Dalton Hughes Diana Waters Kafui Dzirasa Detlev Erdmann J örn Coers Amanda MacLeod Jennifer Y Zhang Source Type: research

A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV
The objective of this study was to evaluate available literature on the possible efficacy of second-line treatments in HSV and the use of second-line treatments in HSV strains that are resistant to first-line treatments. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a final search was conducted in six databases on November 5, 2021 for all relevant literature using terms related to antiviral resistance, herpes, and HSV. Eligible manuscripts were required to report the presence of an existing or proposed second-line treatment for HSV-1, HSV-2, or varicella zoster virus (VZV...
Source: Herpes - April 12, 2023 Category: Infectious Diseases Authors: Kimberly C Lince Virgil K DeMario George T Yang Rita T Tran Daniel T Nguyen Jacob N Sanderson Rachel Pittman Rebecca L Sanchez Source Type: research

Supportive Oligonucleotide Therapy (SOT) as a Potential Treatment for Viral Infections and Lyme Disease: Preliminary Results
This study revealed that for Lyme Disease, one or two SOT administrations can lead to a statistically significant decrease in DNA copies, while for viruses, two or three administrations are required to achieve a statistically significant reduction in the genetic material. These preliminary results indicate that antisense SOT therapy can be considered a potential treatment for viral as well as Lyme diseases.PMID:36412742 | DOI:10.3390/idr14060084
Source: Herpes - November 22, 2022 Category: Infectious Diseases Authors: Panagiotis Apostolou Aggelos Iliopoulos Georgios Beis Ioannis Papasotiriou Source Type: research

Silencing of proinflammatory NF- κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA
Nanoscale Adv. 2022 Sep 5;4(21):4502-4516. doi: 10.1039/d2na00250g. eCollection 2022 Oct 25.ABSTRACTAzide-terminated ultrasmall gold nanoparticles (2 nm gold core) were covalently functionalized with alkyne-terminated small-interfering siRNA duplexes by copper-catalyzed azide-alkyne cycloaddition (CuAAC; click chemistry). The nanoparticle core was visualized by transmission electron microscopy. The number of attached siRNA molecules per nanoparticle was determined by a combination of atomic absorption spectroscopy (AAS; for gold) and UV-Vis spectroscopy (for siRNA). Each nanoparticle carried between 6 and 10 siRNA duplex m...
Source: Herpes - November 7, 2022 Category: Infectious Diseases Authors: Natalie Wolff Sebastian Kollenda Kai Klein Kateryna Loza Marc Heggen Leonie Brochhagen Oliver Witzke Adalbert Krawczyk Ingrid Hilger Matthias Epple Source Type: research

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy
Autophagy. 2022 Nov 7:1-21. doi: 10.1080/15548627.2022.2139921. Online ahead of print.ABSTRACTAlpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-l...
Source: Autophagy - November 7, 2022 Category: Cytology Authors: Zicheng Ma Juan Bai Chenlong Jiang Huixin Zhu Depeng Liu Mengjiao Pan Xianwei Wang Jiang Pi Ping Jiang Xing Liu Source Type: research