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Infectious Disease: Herpes
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Total 89 results found since Jan 2013.
The long non-coding RNA LNC_000397 negatively regulates PRRSV replication through induction of interferon-stimulated genes
CONCLUSIONS: LNC_000397 negatively regulated PRRSV replication by inducing interferon-stimulated genes (ISGs) expression. Our study is the first report unveiling the role of host lncRNA in regulating PRRSV replication, which might be beneficial for the development of novel antiviral therapeutics.PMID:35248059 | DOI:10.1186/s12985-022-01761-x
Source: Herpes - March 6, 2022 Category: Infectious Diseases Authors: Jing Zhang Lipeng Gan Pu Sun Jian Wang Dong Li Yimei Cao Yuanfang Fu Pinghua Li Xingwen Bai Kun Li Xueqing Ma Huifang Bao Yingli Chen Jie Zhang Zaixin Liu Zengjun Lu Source Type: research
Nectin-1 and Non-muscle Myosin Heavy Chain-IIB: Major Mediators of Herpes Simplex Virus-1 Entry Into Corneal Nerves
This study observed that receptors nectin-1, HVEM, 3-OS-HS, NMHC-IIA, and NMHC-IIB, not MAG, were expressed in healthy corneal nerves. Further, we cultured TG neurons extracted from mice in vitro to screen for functional gD/gB receptors. Both in vitro siRNA knockdown and in vivo antibody blocking of either nectin-1 or NMHC-IIB reduced the entry and the replication of HSV-1 as shown by qPCR analysis and immunofluorescence measure, respectively. Also, we observed that the re-localization and the upregulation expression of NMHC-IIB after HSV-1 exposure were inhibited when gD receptor nectin-1 was knocked down. These data sugg...
Source: Frontiers in Microbiology - February 28, 2022 Category: Microbiology Source Type: research
Native RNA Purification Method for Small RNA Molecules Based on Asymmetrical Flow Field-Flow Fractionation
Pharmaceuticals (Basel). 2022 Feb 21;15(2):261. doi: 10.3390/ph15020261.ABSTRACTRNA molecules provide promising new possibilities for the prevention and treatment of viral infections and diseases. The rapid development of RNA biology and medicine requires advanced methods for the purification of RNA molecules, which allow fast and efficient RNA processing, preferably under non-denaturing conditions. Asymmetrical flow field-flow fractionation (AF4) enables gentle separation and purification of macromolecules based on their diffusion coefficients. The aim of the study was to develop an AF4 method for efficient purification o...
Source: Herpes - February 26, 2022 Category: Infectious Diseases Authors: Alesia A Levanova Mirka Lampi Kiira Kalke Veijo Hukkanen Minna M Poranen Katri Eskelin Source Type: research
Adenovirus-mediated RNA interference against herpes simplex virus infection in vitro
CONCLUSIONS: Adenovirus-mediated siRNA-targeting gD and gE genes effectively inhibit the replication of the HSV in Vero cells. In addition, these findings indicate that the prophylactic use of siRNA is far more effective at inhibiting HSV replication than the therapeutic use.PMID:34905214 | DOI:10.5603/FHC.a2021.0031
Source: Folia Histochemica et Cytobiologica - December 14, 2021 Category: Cytology Authors: Lin Chen Zhi-Qiang Pan Chang-Bin Zhai Source Type: research
