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Glabridin Inhibits < em > Aspergillus fumigatus < /em > Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome
CONCLUSION: Glabridin plays an anti-inflammatory role in A. fumigatus challenge via suppression of the Dectin-2 and NLRP3 inflammasome, and plays an anti-fungal role through delaying germination and changing the hyphal integrity.KEY MESSAGESGlabridin plays an anti-inflammatory role in A. fumigatus infection of RAW264.7 cells in a concentration-dependent manner and through Dectin-2 mediation.Glabridin decreases fungal distribution and inflammation in mouse A. fumigatus keratitis.Glabridin inhibits A. fumigatus growth by delaying germination and disrupting cellular structure in vitro.PMID:36785524 | DOI:10.1080/02713683.2022.2164779
Source: Current Eye Research - February 14, 2023 Category: Opthalmology Authors: Lu Zhan Xue Tian Jing Lin Xudong Peng Guiqiu Zhao Source Type: research

Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy
CONCLUSIONS: Our findings demonstrated that Mel-Mic ameliorates hyperosmolarity induced ocular surface damage via PINK1 mediated mitophagy and may represent an effective treatment for DED possibly through acting MT1 receptor.PMID:35179400 | DOI:10.1080/02713683.2021.2022163
Source: Current Eye Research - February 18, 2022 Category: Opthalmology Authors: Jing Xu Peng Chen Guangfen Zhao Susu Wei Qiqi Li Chuanlong Guo Qilong Cao Xianggen Wu Guohu Di Source Type: research

Black carbon induces complement activation via NLRP3 inflammasome in human corneal epithelial cells
CONCLUSIONS: BC particles, including FBC and OBC, triggered complement activation, increasing the protein level of C5b-9 in cultured HCECs. siRNA targeting NLRP3 to inhibit NLRP3 generation reduced C5b-9 protein level in HCECs treated with FBC or OBC particles, indicating that BC induces complement activation potentially through the NLRP3 inflammasome in HCECs.PMID:34375537 | DOI:10.1080/02713683.2021.1967404
Source: Current Eye Research - August 10, 2021 Category: Opthalmology Authors: Qin Long Liqiang Wang Jing Shang Ying Liu Chen Chen Source Type: research

MicroRNA Let-7c-5p-mediated regulation of ERCC6 disrupts autophagic flux in age-related cataract via the binding to VCP
CONCLUSION: In ARC, Let-7c-5p-mediated downregulation of ERCC6 might prevent the degradation of autophagic vacuoles. CSB binds to VCP, inducing autophagosomes to combine with lysosomes and be degraded.PMID:33703976 | DOI:10.1080/02713683.2021.1900273
Source: Current Eye Research - March 11, 2021 Category: Opthalmology Authors: Yu Cao Pengfei Li Guowei Zhang Lihua Kang Tianqiu Zhou Jian Wu Yong Wang Ying Wang Xiaojuan Chen Huaijin Guan Source Type: research

LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Conclusions: Our findings reveal that MALAT1 may regulate EMT, proliferation, and migration of LECs as a ceRNA by "sponging" miR-204-5p and targeting Smad4, and serve as a promising therapeutic target in preventing PCO. PMID: 33327804 [PubMed - as supplied by publisher]
Source: Current Eye Research - December 17, 2020 Category: Opthalmology Authors: Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J Tags: Curr Eye Res Source Type: research

RhoA activation decreases phagocytosis of trabecular meshwork cells.
CONCLUSIONS: These results suggest that the RhoA signal pathway regulates the phagocytic activity of TM cells. PMID: 32847411 [PubMed - as supplied by publisher]
Source: Current Eye Research - August 25, 2020 Category: Opthalmology Authors: Fujimoto T, Sato-Ohira S, Tanihara H, Inoue T Tags: Curr Eye Res Source Type: research

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