Black carbon induces complement activation via NLRP3 inflammasome in human corneal epithelial cells

CONCLUSIONS: BC particles, including FBC and OBC, triggered complement activation, increasing the protein level of C5b-9 in cultured HCECs. siRNA targeting NLRP3 to inhibit NLRP3 generation reduced C5b-9 protein level in HCECs treated with FBC or OBC particles, indicating that BC induces complement activation potentially through the NLRP3 inflammasome in HCECs.PMID:34375537 | DOI:10.1080/02713683.2021.1967404

Source: Current Eye Research - August 10, 2021 Category: Opthalmology Authors: Qin Long Liqiang Wang Jing Shang Ying Liu Chen Chen Source Type: research