MicroRNA Let-7c-5p-mediated regulation of ERCC6 disrupts autophagic flux in age-related cataract via the binding to VCP

CONCLUSION: In ARC, Let-7c-5p-mediated downregulation of ERCC6 might prevent the degradation of autophagic vacuoles. CSB binds to VCP, inducing autophagosomes to combine with lysosomes and be degraded.PMID:33703976 | DOI:10.1080/02713683.2021.1900273

Source: Current Eye Research - March 11, 2021 Category: Opthalmology Authors: Yu Cao Pengfei Li Guowei Zhang Lihua Kang Tianqiu Zhou Jian Wu Yong Wang Ying Wang Xiaojuan Chen Huaijin Guan Source Type: research