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HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes
This study investigated the role of LncRNA HOTAIR knockdown in the biological impacts on cervical cancer cells. The HOTAIR gene in two human cervical cancer cell lines was silenced with small interfering (si) RNA siHOTAIR. Proliferation, apoptosis, migration and invasion of cells were assessed following the knockdown. The expressions of Notch1, EpCAM, E-cadherin, vimentin and STAT3 were assessed using qRT-PCR and Western blotting analysis. Compared with controls, HOTAIR levels were reduced significantly, the OD values of cells were significantly decreased in proliferation assays, cell apoptosis was significantly increased,...
Source: Journal of Obstetrics and Gynaecology - March 27, 2023 Category: OBGYN Authors: Lei Shi Dehui Zhang Huijuan Han Liangyu Zhang Sirui Li Fang Yang Caijun He Source Type: research

Long Non-Coding RNA ZEB1-Antisense 1 Affects Cell Migration and Invasion of Cervical Cancer by Regulating Epithelial-Mesenchymal Transition via the p38MAPK Signaling Pathway
Conclusion: Inhibition of ZEB1-AS1 can block the p38MAPK signaling pathway, ultimately restricting the EMT and suppressing cell migration and invasion of cervical cancer cells.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - October 5, 2018 Category: OBGYN Source Type: research

miR-31 functions as an oncogene in cervical cancer
Conclusions Our results suggested that miR-31 plays an oncogenetic role in the development and progression of cervical cancer.
Source: Archives of Gynecology and Obstetrics - September 29, 2015 Category: OBGYN Source Type: research

Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells
ConclusionIt was suggested that HSP70 played functional roles in the progression of uterine cervical SCC, and HSP70 knockdown enhanced chemosensitivities to cisplatin in cervical SCC cells.
Source: Journal of Obstetrics and Gynaecology Research - April 2, 2014 Category: OBGYN Authors: Keiko Yoshidomi, Akihiro Murakami, Kazuyuki Yakabe, Kotaro Sueoka, Shugo Nawata, Norihiro Sugino Tags: Invited Manuscript Source Type: research