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Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.
This study confirmed that glucose restriction can enhance autophagy, inhibit senescence, and enhance proliferation of HUVECs through the AMPK/SIRT1-FOXA3-Beclin1 pathway. PMID: 32768436 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - August 4, 2020 Category: Geriatrics Authors: Liu Q, Li H, Wang J, Zhong L, Chen X, Zhang R, Wang H Tags: Exp Gerontol Source Type: research

Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy.
Authors: Hou X, Li Z, Higashi Y, Delafontaine P, Sukhanov S Abstract Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. Insulin-like growth factor 1 (IGF-1) promotes survival of smooth muscle cells (SMCs), but its potential effect on cellular aging is unknown yet. We found that IGF-1 decreased cell senescence, prevented DNA telomere shortening, increased mitochondrial membrane potential, activated cytochrome C oxidase, and reduced mitochondrial DNA damage in long-term cul...
Source: Journal of Aging Research - August 19, 2020 Category: Geriatrics Tags: J Aging Res Source Type: research

Aging induces abnormal accumulation of A β in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain
Neurobiol Aging. 2021 Jul 5;106:268-281. doi: 10.1016/j.neurobiolaging.2021.06.022. Online ahead of print.ABSTRACTAβ metabolism in the brain is mediated by endocytosis, one part of the intracellular membrane trafficking system. We previously showed that aging attenuates the interaction of dynein with dynactin, which disrupts the endosomal/lysosomal trafficking pathway involved in Aβ metabolism, resulting in intracellular accumulation of Aβ. Several studies have shown that in Alzheimer's disease (AD), intraneuronal accumulation of Aβ precedes extracellular Aβ depositions. However, it is unclear what accounts for this t...
Source: Neurobiology of Aging - July 30, 2021 Category: Geriatrics Authors: Shingo Koinuma Nobuhiro Shimozawa Yasuhiro Yasutomi Nobuyuki Kimura Source Type: research

Changes in AMPK activity induces cellular senescence in human dental follicle cells
This study examined the role of AMPK in inducing senescence in DFCs. During the induction of cellular senescence, AMPK activity was impaired, suggesting a negative impact on senescence induction. In line with this assumption, cellular senescence was induced upon inhibition of AMPK with a specific siRNA. In addition, after this inhibition, autophagy was also inhibited. Moreover, specific inhibition of autophagy promoted cellular senescence. However, inducers of AMPK such as metformin or AICAR surprisingly increased senescence in DFCs. Interestingly, autophagy was impaired after long-term induction of AMPK with AICAR and met...
Source: Experimental Gerontology - December 23, 2022 Category: Geriatrics Authors: Christian Morsczeck Anja Reck Torsten E Reichert Source Type: research

Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling
In conclusion, the inhibition of osteocalcin on muscle cell aging is accompanied by the induction of IL-6-STAT3-dependent autophagy, indicating osteocalcin might be a promising therapeutic candidate for aging-related myopathies.PMID:36621698 | DOI:10.1016/j.exger.2023.112082
Source: Experimental Gerontology - January 9, 2023 Category: Geriatrics Authors: Pengying Gu Daidi Tao Yuanyuan Xu Qian Yang Tingting Bai Shilian Hu Xingyuan Yang Source Type: research

SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway
In conclusions, the S-protein of SARS-Cov-2 induces cellular senescence of ARPE-19 cells in vitro and the expression of senescence-associated cytokines in zebrafish retina in vivo likely by activating ER stress, ROS, and NF-κb. These results may uncover a potential association between SARS-cov-2 infection and development of AMD.PMID:36738354 | DOI:10.1007/s10522-023-10019-0
Source: Biogerontology - February 4, 2023 Category: Geriatrics Authors: Yuhang Zhang Xuyan Peng Mengjiao Xue Jingjing Liu Guohui Shang Mingjun Jiang Dandan Chen Baixue Liu Yuxuan Wang Xiaolin Jia Jianqing Xu Fengyan Zhang Yanzhong Hu Source Type: research

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