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Cancer: Breast Cancer

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Total 23 results found since Jan 2013.

Synchronous targeted delivery of TGF- β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Biomaterials. 2023 Jul 25;301:122253. doi: 10.1016/j.biomaterials.2023.122253. Online ahead of print.ABSTRACTThe poor permeability of therapeutic drugs, limited T-cell infiltration, and strong immunosuppressive tumor microenvironment of triple-negative breast cancer (TNBC) acts as a prominent barrier to the delivery of drugs and immunotherapy including programmed cell death ligand-1 antibody (anti-PD-L1). Transforming growth factor (TGF)-β, an important cytokine produced by cancer-associated fibroblasts (CAFs) and tumor cells contributes to the pathological vasculature, dense tumor stroma and strong immunosuppressive tumo...
Source: Biomaterials - August 3, 2023 Category: Materials Science Authors: Mengmeng Yang Chao Qin Linlin Tao Gang Cheng Jingjing Li Fangnan Lv Nan Yang Zuhang Xing Xinyu Chu Xiaopeng Han Meirong Huo Lifang Yin Source Type: research

The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment
In this study, we successfully constructed a programmed site-specific delivery nanosystem for the combined delivery of transforming growth factor beta (TGF-β) receptor inhibitor LY3200882 (LY) and PD-L1 siRNA (siPD-L1) to boost anti-tumor immunotherapy. As expected, LY in the outer layer of the nanosystem was released by stimulation of MMP2, and dramatically down-regulated the expression of extracellular matrix (ECM) in the tumor-associated fibroblasts (TAFs), and thus promoted the infiltration of effector T cells and penetration of nanomedicines. Simultaneously, the blockade of TGF-β by LY also triggered immunogenic cel...
Source: Biomaterials - April 24, 2022 Category: Materials Science Authors: Pan Zhang Chao Qin Nan Liu Xinyuan Zhou Xuxin Chu Fangnan Lv Yongwei Gu Lifang Yin Jiyong Liu Jianping Zhou Meirong Huo Source Type: research

ASAP Combinational Chemoimmunotherapy for Breast Cancer by Codelivery of Doxorubicin and PD-L1 siRNA Using a PAMAM-Incorporated Liposomal Nanoplatform
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c21775
Source: ACS Applied Materials and Interfaces - February 9, 2022 Category: Materials Science Authors: Qing Hu, Jiayi Yao, Xiaoqin Wang, Yanfang Wang, Xiaoling Fu, Ju Ma, Han Lin, Jiaqi Xu, Longhua Shen, and Xiangbin Yu Source Type: research

Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis
Biomaterials. 2021 Jun 24;275:120988. doi: 10.1016/j.biomaterials.2021.120988. Online ahead of print.ABSTRACTPD-L1/PD-1 blockade therapy shows durable responses to triple-negative breast cancer (TNBC), but the response rate is low. CD155 promotes tumor metastasis intrinsically and modulates the immune response extrinsically as the ligand of DNAM-1 (costimulatory receptor) and TIGIT/CD96 (coinhibitory receptors). Herein, we verified that TNBC cells coexpressed PD-L1 and CD155. By examining the receptors of PD-L1 and CD155 on TNBC tumor-infiltrating lymphocytes (TILs) over time, we observed that PD-1 and DNAM-1 were upregula...
Source: Biomaterials - June 29, 2021 Category: Materials Science Authors: Chuanrong Chen Qianqian Guo Hao Fu Jian Yu Liting Wang Ying Sun Jiali Zhang Yourong Duan Source Type: research

Development of lipid nanoparticles for delivery of siRNA to neural cells
Lipid nanoparticles (LNPs) are a clinically approved platform to deliver siRNA to the liver. We are optimizing this platform to deliver siRNA for the treatment of pain. siRNA against TRPV1 (siTRPV1) was chosen as a proof of concept. siTRPV1-LNPs were formulated using C12-200, an ionizable cationic lipid and helper lipids. Their particle size and surface charge was characterized using dynamic light scattering and siRNA encapsulation efficiency was determined using a Ribogreen assay. A panel of breast cancer cell lines (MCF-7, MDA-MB-231 and BT-549) that express TRPV1 were selected for in vitro screening of LNPs to determine...
Source: The Journal of Pain - May 1, 2021 Category: Materials Science Authors: Purva Khare, Kandarp Dave, Jane Hartung, Michael Gold, Devika Manickam Source Type: research

Targeted-delivery of siRNA via a polypeptide-modified liposome for the treatment of gp96 over-expressed breast cancer
Publication date: Available online 6 January 2021Source: Materials Science and Engineering: CAuthor(s): Ze Liang, Linying Du, Enxia Zhang, Yinan Zhao, Wei Wang, Pengfei Ma, Mengyuan Dai, Qi Zhao, Hong Xu, Shubiao Zhang, Yuhong Zhen
Source: Materials Science and Engineering: C - January 6, 2021 Category: Materials Science Source Type: research

ASAP Systemic Delivery of Aptamer-Conjugated XBP1 siRNA Nanoparticles for Efficient Suppression of HER2+ Breast Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.0c07353
Source: ACS Applied Materials and Interfaces - July 10, 2020 Category: Materials Science Authors: Long Zhang †§‡, Chaofeng Mu?‡, Tinghong Zhang†§, Yingying Wang†§, Yili Wang†§, Luhui Fan?, Cong Liu?, Hao Chen†§, Jianliang Shen*†§, Kun Wei*†§, and Huaqiong Li*†§ Source Type: research

Multifunctional hybrid nanoparticles as magnetic delivery systems for siRNA targeting the HER2 gene in breast cancer cells
In this study, we prepared a magnetic hybrid nanostructure composed of iron oxide nanoparticles coated with caffeic acid and stabilized by layers of calcium phosphate and PEG-polyanion block copolymer for incorporation of siRNA. Transmission electron microscopy images showed monodisperse, neutrally charged compact spheres sized <100 nm. Dynamic light scattering and nanoparticle tracking analysis revealed that the nanostructure had an average hydrodynamic diameter of 130 nm. Nanoparticle suspensions remained stable over 42 days of storage at 4 and 25 °C. Unloaded caffeic acid–magnetic calcium phosphate (Caf-MCaP)...
Source: Materials Science and Engineering: C - December 26, 2019 Category: Materials Science Source Type: research

Magnetically responsive hybrid nanoparticles for in vitro siRNA delivery to breast cancer cells
Publication date: June 2019Source: Materials Science and Engineering: C, Volume 99Author(s): Milene Dalmina, Frederico Pittella, Jelver Alexander Sierra, Gabriela Regina Rosa Souza, Adny Henrique Silva, André Avelino Pasa, Tânia Beatriz Creczynski-PasaAbstractShort interfering RNA (siRNA) showed to be a viable alternative to a better prognosis in cancer therapy. Nevertheless, the successful application of this strategy still depends on the development of nanocarriers for the safe delivery of siRNA into the diseased tissue, which mostly occurs by passive accumulation. When an external magnetic field is applied, magnetic n...
Source: Materials Science and Engineering: C - February 23, 2019 Category: Materials Science Source Type: research

ASAP Engineered Histidine-Enriched Facial Lipopeptides for Enhanced Intracellular Delivery of Functional siRNA to Triple Negative Breast Cancer Cells
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b13794
Source: ACS Applied Materials and Interfaces - January 24, 2019 Category: Materials Science Authors: Abhijit Biswas, Kasturee Chakraborty, Chiranjit Dutta, Sanchita Mukherjee, Paramita Gayen, Somnath Jan, Argha Mario Mallick, Dhananjay Bhattacharyya, Rituparna Sinha Roy Source Type: research

Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression.
This study demonstrated that NgBR is a promising therapeutic target in abnormal tumor vasculature and aggressive cancer cells, and the tumor-responsive nanoparticle with the feature of charge transformation offers great potential for tumor-specific delivery of gene therapeutics. PMID: 29803999 [PubMed - as supplied by publisher]
Source: Biomaterials - May 21, 2018 Category: Materials Science Authors: Wang B, Ding Y, Zhao X, Han X, Yang N, Zhang Y, Zhao Y, Zhao X, Taleb M, Miao QR, Nie G Tags: Biomaterials Source Type: research

Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer.
Abstract To improve the non-invasive therapeutic efficacy for ER positive breast cancer (ER+ BC), we fabricated a multifunctional FOXA1 loaded porphyrin microbubble to combine photodynamic therapy (PDT) and gene therapy of FOXA1 knockdown (KD) with ultrasound targeted microbubble destruction (UTMD) technology under the guidance of contrast enhanced ultrasound (CEUS). Cationic porphyrin microbubbles (CpMBs) were firstly fabricated from a porphyrin grafted lipid with two cationic amino groups (PGL-NH2) and fluorocarbon inert gas of C3F8. Porphyrin group in the CpMBs monolayer could be used as a photosensitizer for ...
Source: Biomaterials - May 3, 2018 Category: Materials Science Authors: Zhao R, Liang X, Zhao B, Chen M, Liu R, Sun S, Yue X, Wang S Tags: Biomaterials Source Type: research