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Specialty: Cytology
Procedure: Transplants
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Total 48 results found since Jan 2013.
New and future therapies: Changes in the therapeutic armamentarium for SLE
Best Pract Res Clin Rheumatol. 2023 Aug 24:101865. doi: 10.1016/j.berh.2023.101865. Online ahead of print.ABSTRACTFollowing better understanding of molecular pathways involved in the pathogenesis of Systemic lupus erythematosus (SLE), pharmaceutical companies have been investigating new targeted drugs for SLE. The purpose of this scoping review is to provide an updated view of the most promising targeted therapies currently in clinical development or recently approved for SLE treatment as well as of the most promising potential future therapeutic strategies in SLE. In the past several years, two new drugs have been develop...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anca Askanase Leila Khalili Wei Tang Philippe Mertz Marc Scherlinger Eden Sebbag Fran çois Chasset Renaud Felten Laurent Arnaud Source Type: research
Linc-ROR Regulates < em > POU5F1 < /em > and < em > SOX2 < /em > by Competitively Binding miR-145-5p to Affect the Proliferation and Migration of Gastric Cancer Cells
In this study, in situ hybridization revealed that long intergenic non-protein coding RNA-regulator of reprogramming (linc-ROR) was highly expressed in gastric cancer cells and was mainly cytoplasmic-positive. Cell counting kit-8 (CCK-8), plate colony formation, wound healing, and Transwell assay revealed that linc-ROR knockdown impedes the growth, proliferation, and migration of gastric cancer cells, while linc-ROR overexpression promoted gastric cancer cell growth, migration, and colony formation ability. Combined with previous studies, the molecular mechanism axis of linc-ROR/miR-145-5-5p/POU5F1/SOX2 was verified. The e...
Source: Cell Transplantation - June 12, 2023 Category: Cytology Authors: Xiuchong Yu Xinyi Ma Yangtao Jia Xinxin Wu Zhilong Yan Source Type: research
Endogenous Follistatin-like 1 guarantees the immunomodulatory properties of mesenchymal stem cells during liver fibrotic therapy
CONCLUSIONS: Our data suggest that FSTL1 facilitates the immunosuppression of MSCs on macrophages and that guarantee the anti-fibrotic effect of MSCs in liver fibrosis.PMID:35932064 | DOI:10.1186/s13287-022-03042-4
Source: Cell Research - August 5, 2022 Category: Cytology Authors: Xiaohong Zheng Xia Zhou Gang Ma Jiahao Yu Miao Zhang Chunmei Yang Yinan Hu Shuoyi Ma Zheyi Han Wen Ning Boquan Jin Xinmin Zhou Jingbo Wang Ying Han Source Type: research
CD73 promotes cervical cancer growth via EGFR/AKT1 pathway
CONCLUSIONS: Our data demonstrated that CD73 overexpression promote cervical cancer growth in vitro and in vivo, via activating EGFR/AKT1 pathway.PMID:35706815 | PMC:PMC9189233 | DOI:10.21037/tcr-21-2446
Source: Cell Research - June 16, 2022 Category: Cytology Authors: Chong Liu Zhao-Wei Gao Xi Wang Fang Lin Hui-Zhong Zhang Ke Dong Source Type: research
Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK
Cell Mol Neurobiol. 2022 Apr 18. doi: 10.1007/s10571-022-01221-8. Online ahead of print.ABSTRACTSodium-glucose transporter 2 (SGLT2) inhibitors are antidiabetic drugs affecting SGLT2. Recent studies have shown various cancers expressing SGLT2, and SGLT2 inhibitors attenuating tumor proliferation. We evaluated the antitumor activities of canagliflozin, a SGLT2 inhibitor, on glioblastoma (GBM). Three GBM cell lines, U251MG (human), U87MG (human), and GL261 (murine), were used. We assessed the expression of SGLT2 of GBM through immunoblotting, specimen-use, cell viability assays, and glucose uptake assay with canagliflozin. T...
Source: Cellular and Molecular Neurobiology - April 18, 2022 Category: Cytology Authors: Kenji Shoda Shohei Tsuji Shinsuke Nakamura Yusuke Egashira Yukiko Enomoto Noriyuki Nakayama Masamitsu Shimazawa Toru Iwama Hideaki Hara Source Type: research
Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis
CONCLUSION: The current findings reveal that sevoflurane preconditioned MSCs boost angiogenesis in HUVECs subjected to H/R insult and attenuate myocardial I/R injury, which may be mediated by TRPC6 up-regulated HIF-1α, CXCR4 and VEGF.PMID:34809715 | DOI:10.1186/s13287-021-02649-3
Source: Cell Research - November 23, 2021 Category: Cytology Authors: Jinting Yang Lihui Tang Fengjiang Zhang Tingting Yang Ting Lu Kai Sun Na Sun Jinxuan Ren Min Yan Source Type: research
Nanog/NFATc1/Osterix signaling pathway-mediated promotion of bone formation at the tendon-bone interface after ACL reconstruction with De-BMSCs transplantation
CONCLUSIONS: De-BMSCs transplantation could promote bone formation at the tendon-bone interface after ACLR and improve the biomechanical strength of the reconstruction. The Nanog/NFATc1/Osterix signaling pathway mediated the enhanced osteogenic differentiation efficiency of De-BMSCs.PMID:34775995 | DOI:10.1186/s13287-021-02643-9
Source: Cell Research - November 15, 2021 Category: Cytology Authors: Kai Tie Jinghang Cai Jun Qin Hao Xiao Yangfan Shangguan Hui Wang Liaobin Chen Source Type: research
MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3 β/β-catenin Signaling Axis
In conclusion, the oncogenic role and related mechanisms of MsrB1 in CRC discovered in our work determined the potential role of MsrB1 as a biomarker and may provide a new target for clinical therapy of CRC.PMID:34719306 | PMC:PMC8558597 | DOI:10.1177/09636897211053203
Source: Cell Transplantation - November 1, 2021 Category: Cytology Authors: Xiao-Yu Chen Sheng-Yong Yang Xiao-Jie Ruan Hong-Yue Ding Ning-Xi Wang Fang Liu Jia-Chu Li Yi Li Source Type: research
