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Specialty: Cytology
Condition: Mitochondrial Disease

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Total 35 results found since Jan 2013.

Neuroprotective effects of the PPAR β/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models
CONCLUSIONS: In summary, PPARβ/δ antagonist displayed neuroprotective activities against 6-hydroxydopamine detrimental effects both in vitro and in vivo models of Parkinson's disease, suggesting that it may represent a novel therapeutic approach for this disorder.PMID:37226204 | DOI:10.1186/s40659-023-00438-1
Source: Cell Research - May 24, 2023 Category: Cytology Authors: Andrea Antonosante Vanessa Castelli Martina Sette Margherita Alfonsetti Mariano Catanesi Elisabetta Benedetti Matteo Ardini Annamaria Cimini Michele d'Angelo Source Type: research

Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation
In conclusion, our findings uncovered that I3A increased hepatic PGC1a expression, contributing to mitochondrial respiration improvement in NAFLD.PMID:35988807 | DOI:10.1016/j.cellsig.2022.110442
Source: Cellular Signalling - August 21, 2022 Category: Cytology Authors: Chen Zhang Qingsong Fu Kai Shao Limin Liu Xiaotian Ma Fengyi Zhang Xiaodong Zhang Liying Meng ChuanZhu Yan Xiaoyun Zhao Source Type: research

PGC-1 α attenuates TNF-α-induced inflammatory responses in OCCM-30 cells
CONCLUSIONS: PGC-1α can attenuate TNF-α-induced inflammatory responses in OCCM-30 cells.PMID:35903958 | DOI:10.1111/jre.13042
Source: Cell Research - July 29, 2022 Category: Cytology Authors: Yihui Fu Mingyuan Du Zhengguo Cao Hong He Source Type: research

EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
This study establishes loss of dependency on EPAC-mTORC1 signaling as hallmark of primary melanoma evolution and targeting this escape mechanism is a promising strategy for metastatic melanoma.PMID:35834616 | DOI:10.1158/1541-7786.MCR-22-0026
Source: Cell Research - July 14, 2022 Category: Cytology Authors: Aishwarya Krishnan Aishwarya I Bhasker Mithalesh K Singh Carlos I Rodriguez Edgardo Castro-Perez Sarah Altameemi Marcos Lares Hamidullah Khan Mary Ndiaye Nihal Ahmad Stefan M Schieke Vijayasaradhi Setaluri Source Type: research

Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway
In this study, we attempted to investigate a novel mechanism by which WG mitigates liver fibrosis by inducing ferroptosis in hepatic stellate cells (HSCs). A CCl4 -induced mouse liver fibrosis model and a rat HSC line were employed for in vivo and in vitro experiments, both treated with WG. Firstly, the levels of the fibrotic markers α-smooth muscle actin (α-SMA) and α1(I)collagen (COL1α1) were effectively decreased by WG in CCl4 -induced mice and HSC-T6 cells. Additionally, mitochondrial condensation and mitochondrial ridge breakage were observed in WG-treated HSC-T6 cells. Furthermore, ferroptotic events including de...
Source: Cell Research - July 11, 2022 Category: Cytology Authors: Guofang Liu Can Wei Siyu Yuan Zhe Zhang Jiahao Li Lijun Zhang Guokai Wang Ling Fang Source Type: research

Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
Biochem Biophys Res Commun. 2022 Mar 31;608:156-162. doi: 10.1016/j.bbrc.2022.03.156. Online ahead of print.ABSTRACTCalpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is activated during endoplasmic reticulum (ER) stress. However, the substrate of calpain-5, as well as the physiological significance of calpain-5 activation, has...
Source: Cell Research - April 10, 2022 Category: Cytology Authors: Yusaku Chukai Ginga Ito Masahide Konno Yuri Sakata Taku Ozaki Source Type: research

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
CONCLUSION: SDP protected renal tubular epithelial cells from cell pyroptosis and EMT by regulating the albumin-induced mitochondrial dysfunction/ MAVS/ NLRP3-ASC-caspase-1 inflammasome signaling pathway.PMID:34908861 | PMC:PMC8665879 | DOI:10.2147/JIR.S341598
Source: Cell Research - December 15, 2021 Category: Cytology Authors: Yiye Zhu Guoshun Huang Yang Yang Chen Yong Xiang Yu Gang Wang Lan Yi Kun Gao Fang Tian Shushu Qian Enchao Zhou Yanqin Zou Source Type: research

Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells
In this study, we show that NDV infection reprograms cell metabolism by increasing glucose utilization in the glycolytic pathway. Mechanistically, NDV induces mitochondrial damage, elevated mitochondrial reactive oxygen species (mROS) and ETC dysfunction. Infection of cells depletes nucleotide triphosphate levels, resulting in elevated AMP:ATP ratios, AMP-activated protein kinase (AMPK) phosphorylation, and MTOR crosstalk mediated autophagy. In a time-dependent manner, NDV shifts the balance of mitochondrial dynamics from fusion to fission. Subsequently, PINK1-PRKN-dependent mitophagy was activated, forming a ubiquitin cha...
Source: Autophagy - November 1, 2021 Category: Cytology Authors: Yabin Gong Ning Tang Panrao Liu Yingjie Sun Shanxin Lu Weiwei Liu Lei Tan Cuiping Song Xusheng Qiu Ying Liao Shengqing Yu Xiufan Liu Shu-Hai Lin Chan Ding Source Type: research

Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death
This study uncovers the unexpected role of immune surveillance protein DDX58/Rig-1 (DExD/H box helicase 58) in activating macroautophagy/autophagy and protecting from lipotoxicity associated with NAFLD. Here we show for the first time that DDX58 protein is significantly reduced in nonalcoholic steatohepatitis (NASH) mouse model, an aggressive form of NAFLD characterized by inflammation and fibrosis of the liver. In addition to decreased expression of DDX58, we found that DDX58 activity can be attenuated by treatments with palmitic acid (PA), a saturated fatty acid. To investigate whether PA inhibition of DDX58 is harmful t...
Source: Autophagy - May 10, 2021 Category: Cytology Authors: Karla K Frietze Alyssa M Brown Dividutta Das Raymond G Franks Jessie Lee Cunningham Michael Hayward Joseph T Nickels Source Type: research

Src-mediated Tyr353 phosphorylation of IP3R1 promotes its stability and causes apoptosis in palmitic acid-treated hepatocytes.
Conclusion: PA promotes the Tyr353 phosphorylation of IP3R1 by activating the src pathway and increasing the protein stability of IP3R1, which consequently results in mitochondrial Ca2+ overload and mitochondrial dysfunction in hepatic cells. Our results also suggested that inhibition of the src/IP3R1 pathway, such as by SU6656, may be a novel potential therapeutic approach for the treatment of NAFLD. PMID: 33358861 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - December 21, 2020 Category: Cytology Authors: Yu T, Zheng E, Li Y, Li Y, Xia J, Ding Q, Hou Z, Ruan XZ, Zhao L, Chen Y Tags: Exp Cell Res Source Type: research

TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Abstract Impaired macroautophagy/autophagy has been implicated in experimental and human nonalcoholic steatohepatitis (NASH). However, the mechanism underlying autophagy dysregulation in NASH is largely unknown. Here, we investigated the role and mechanism of TXNIP/VDUP1 (thioredoxin interacting protein), a key mediator of cellular stress responses, in the pathogenesis of NASH. Hepatic TXNIP expression was upregulated in nonalcoholic fatty liver disease (NAFLD) patients and in methionine choline-deficient (MCD) diet-fed mice, as well as in palmitic acid (PA)-treated hepatocytes. Upregulation of hepatic TXNIP was p...
Source: Autophagy - November 16, 2020 Category: Cytology Authors: Park HS, Song JW, Park JH, Lim BK, Moon OS, Son HY, Lee JH, Gao B, Won YS, Kwon HJ Tags: Autophagy Source Type: research