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Specialty: Cytology
Cancer: Hepatocellular Carcinoma
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Total 110 results found since Jan 2013.
Downregulation of < em > CLDN6 < /em > inhibits cell migration and invasion and promotes apoptosis by regulation of the JAK2/STAT3 signaling pathway in hepatocellular carcinoma
CONCLUSIONS: CLDN6 knockdown results in the inhibition of HCC cells' infiltration and migration and promotes apoptosis via downregulation of the JAK2/STAT3 signaling pathway.PMID:37588735 | PMC:PMC10425638 | DOI:10.21037/tcr-23-19
Source: Cell Research - August 17, 2023 Category: Cytology Authors: Zhiyi He Fangtian Fan Zhidong Xu Mei Zhang Rui Zhao Xiquan Ke Qizhi Wang Shanjun Yan Hailun Zheng Source Type: research
The abrogation of GRP78 sensitizes liver cancer cells to lysionotin by enhancing ER stress-mediated pro-apoptotic pathway
Cell Stress Chaperones. 2023 Jun 16. doi: 10.1007/s12192-023-01358-5. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78) is frequently and highly expressed in various human malignancies and protects cancer cells against apoptosis induced by multifarious stresses, particularly endoplasmic reticulum stress (ER stress). The inhibition of GRP78 expression or activity could enhance apoptosis induced by anti-tumor drugs or compounds. Herein, we will evaluate the efficacy of lysionotin in the treatment of human liver cancer as well as the molecular mechanism. Moreover, we will examine whether inhibition of GRP78 e...
Source: Cell Stress and Chaperones - June 16, 2023 Category: Cytology Authors: Ying Zou Hewen Shi Haiyan Lin Xiaoxue Wang Guoli Wang Yijia Gao Fan Yi Yancun Yin Defang Li Minjing Li Source Type: research
MiR-767-3p promotes the progression of hepatocellular carcinoma via targeting CASP-3/-9
CONCLUSION: MiR-767-3p promoted proliferation and prevented apoptosis in human hepatocellular carcinoma (HCC) through inhibiting the caspase-3/caspase-9 pathway.PMID:37193190 | PMC:PMC10182511
Source: Cell Research - May 16, 2023 Category: Cytology Authors: Maolin Wu Jing Deng Dejiao Yao Shijie Li Source Type: research
Comprehensive Analysis of NABP2 as a Prognostic Biomarker and Its Correlation with Immune Infiltration in Hepatocellular Carcinoma
CONCLUSION: Based on these findings, NABP2 appears to be a candidate biomarker for HCC prognosis and immunotherapy.PMID:37113629 | PMC:PMC10128078 | DOI:10.2147/JIR.S403370
Source: Cell Research - April 28, 2023 Category: Cytology Authors: Bowen Li Jinghang Liu Liangzhi Xu Qi Xu Zhaohui Liu Tiande Liu Source Type: research
Stratifin promotes the growth and proliferation of hepatocellular carcinoma
CONCLUSIONS: Our results suggest that SFN may play an important role in HCC progression and may interact with CDC25B to promote malignant progression of HCC, providing a molecular target for future HCC therapy.PMID:36996719 | DOI:10.1016/j.tice.2023.102080
Source: Tissue and Cell - March 30, 2023 Category: Cytology Authors: Xinyu Zhao Enqin Wang Hongkun Xu Lihong Zhang Source Type: research
ETS-1/c-Met drives resistance to sorafenib in hepatocellular carcinoma
CONCLUSION: c-Met overexpression and activation is an essential mechanism of sorafenib resistance in HCC. Combination therapy of sorafenib plus c-Met inhibitor overcame the resistance of sorafenib-targeted therapy for HCC.PMID:36915773 | PMC:PMC10006745
Source: Cell Research - March 14, 2023 Category: Cytology Authors: Yongfang Ma Xueke Liu Xiaolong Tang Source Type: research
SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway
Biochem Biophys Res Commun. 2022 Nov 12;637:161-169. doi: 10.1016/j.bbrc.2022.11.015. Online ahead of print.ABSTRACTThe influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells was investigated. HCC cells were transfected with siRNA and lentivirus to achieve SOS1 knock down/overexpression and changes in RNA and protein levels analyzed by q-PCR and Western blotting (WB). Transwell assay was utilized to assess variations in cell invasion and migration in vitro and by a lung metastasis model of liver cancer in vivo. High expression of SOS1 was observed in most human liv...
Source: Cell Research - November 20, 2022 Category: Cytology Authors: Yonghe Li Yaolin Yin Yi He Kun He Jingdong Li Source Type: research
GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth
In conclusion, we demonstrate that GOLM1 depletion affects sphingolipid metabolism, mitochondrial function, Golgi structure, and proliferation of HCC cells.PMID:35948172 | DOI:10.1016/j.jlr.2022.100259
Source: Cell Research - August 10, 2022 Category: Cytology Authors: Meghana Nagaraj Marcus H öring Maria A Ahonen Van Dien Nguyen You Zhou Helena Vihinen Eija Jokitalo Gerhard Liebisch P A Nidhina Haridas Vesa M Olkkonen Source Type: research
CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1
Exp Cell Res. 2022 Jul 7:113279. doi: 10.1016/j.yexcr.2022.113279. Online ahead of print.ABSTRACTCholesterol homeostasis plays an important role in the maintenance of normal body functions. CYP27A1 is a key enzyme known to regulate cholesterol homeostasis, which catalyzes the conversion of cholesterol to 27-HC and has been implicated in the occurrence and metastasis of various cancer types. The present study aimed to explore the regulatory role of CYP27A1 in the development of clear cell renal cell carcinoma (ccRCC). In particular, the effect of CYP27A1 on the proliferation and migration of ccRCC cells was investigated. Th...
Source: Experimental Cell Research - July 10, 2022 Category: Cytology Authors: Zhijuan Liang Wei Jiao Liping Wang Yuanbin Chen Dan Li Zhao Zhang Zhilei Zhang Ye Liang Haitao Niu Source Type: research
