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New treatments to reach functional cure: Virological approaches
Publication date: Available online 22 May 2017 Source:Best Practice & Research Clinical Gastroenterology Author(s): David Durantel Current therapies of chronic hepatitis B (CHB) remain limited to pegylated-interferon-alpha (pegIFN-α) or any of the five approved nucleos(t)ide analogues (NA). If viral suppression can be achieved in the majority of patients with the high-barrier-to-resistance new-generation of NA, i.e. entecavir and tenofovir, HBsAg loss is achieved by PEG-IFN-α and/or NA in only 10% of patients, after a 5-year follow-up. Attempts to improve the response by administering two different NA or a combi...
Source: Best Practice and Research Clinical Gastroenterology - May 22, 2017 Category: Gastroenterology Source Type: research

Hepatic stellate cells secrete WFA+ ‐M2BP; its role in biological interactions with Kupffer cells
ConclusionsWFA+‐M2BP from HSCs induces Mac‐2 expression in KCs, which in turn activates HSCs to be fibrogenic.
Source: Journal of Gastroenterology and Hepatology - November 30, 2016 Category: Gastroenterology Authors: Yuki Bekki, Tomoharu Yoshizumi, Shinji Shimoda, Shinji Itoh, Norifumi Harimoto, Toru Ikegami, Atsushi Kuno, Hisashi Narimatsu, Ken Shirabe, Yoshihiko Maehara Tags: Original Article ‐ Hepatology (Experimental) Source Type: research

Transarterial chemoembolization aggravated peritumoral fibrosis via HIF‐1α dependent pathway in hepatocellular carcinoma
ConclusionsOur data demonstrate that TACE‐induced hepatic hypoxia aggravates the fibrosis progression in peritumoral liver tissue, thus leads to the deterioration of liver function. Intervention of HIF‐1α might be a valuable strategy to optimize the efficacy and reduce the complication of TACE.
Source: Journal of Gastroenterology and Hepatology - December 31, 2014 Category: Gastroenterology Authors: Kai Qu, Zhaoyong Yan, Yousheng Wu, Yibing Chen, Ping Qu, Xinsen Xu, Peng Yuan, Xiaojun Huang, Jinliang Xing, Hongxin Zhang, Chang Liu, Jing Zhang Tags: Experimental Hepatology Source Type: research

Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
Conclusions Our data suggested that BMSCs inhibited CFSC activation in vitro via the AM-Ang II-p47-phox signaling pathway, and since CFSC activation is an essential part of hepatic fibrosis process, this inhibition by BMSCs implies us new insights into the potential treatment of hepatic fibrosis via BMSCs.
Source: Digestive Diseases and Sciences - December 2, 2014 Category: Gastroenterology Source Type: research

Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.
CONCLUSION: OPN is a key mediator of the alcohol-induced effects on hepatic stellate cell functions and liver fibrogenesis. PMID: 25278703 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS Tags: World J Gastroenterol Source Type: research

Ursolic acid via LKB1‐AMPK signaling suppresses oxidative stress and improves liver functions in mice
ConclusionUA via LKB1‐AMPK signaling offers protective effects on BDL‐induced liver injury in mice, which may be related to inhibition of oxidative stress.
Source: Journal of Gastroenterology and Hepatology - August 28, 2014 Category: Gastroenterology Authors: Yang Yongbin, Zhao Zhanxue, Liu Yuanjun, Kang Xianjiang, Zhang Haisong, Meng Ming Tags: Experimental Hepatology Source Type: research

Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome
Conclusions This study demonstrates specific genomic alterations in HCC/MS and points to CUL7 as a novel gene potentially involved in liver carcinogenesis associated with MS, the amplification of which might influence cell proliferation.
Source: Gut - April 30, 2013 Category: Gastroenterology Authors: Paradis, V., Albuquerque, M., Mebarki, M., Hernandez, L., Zalinski, S., Quentin, S., Belghiti, J., Soulier, J., Bedossa, P. Tags: Hepatic cancer Hepatology Source Type: research

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
Conclusions: In conclusion, we reported an additional mechanism for HCV evasion of host interferon responses in which viral NS4B protein targets STING/MITA to suppress the interferon signaling. Our results present important evidence for the control of interferon response by HCV, and shed more light on the molecular mechanisms underlying the persistence of HCV infection.
Source: Journal of Hepatology - March 29, 2013 Category: Gastroenterology Authors: Qiang Ding, Xuezhi Cao, Jie Lu, Bing Huang, Yong-Jun Liu, Nobuyuki Kato, Hong-Bing Shu, Jin Zhong Tags: Viral Hepatitis Source Type: research