• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

ATF4-mediated CD36 Upregulation Contributes to Palmitate-induced Lipotoxicity in Hepatocytes
In this study, our data revealed for the first time that ATF4 plays a critical role in mediating hepatic CD36 expression. Genetic inhibition of ATF4 attenuated CD36 upregulation induced by either palmitate or ER stress inducer tunicamycin in hepatocytes. In mice, tunicamycin upregulates liver CD36 expression, whereas hepatocyte-specific ATF4 knockout mice manifest lower hepatic CD36 expression when compared to control animals. Furthermore, we demonstrated that CD36 upregulation upon palmitate exposure represents a feedforward mechanism in that siRNA knockdown of CD36 in hepatocytes blunted ATF4 activation induced by both p...
Source: Am J Physiol Gastroi... - February 28, 2023 Category: Gastroenterology Authors: Alexandra Griffiths Jun Wang Qing Song Samuel Man Lee Jose Cordoba-Chacon Zhenyuan Song Source Type: research

Knockdown of FGFR3 inhibits the proliferation, migration and invasion of intrahepatic cholangiocarcinoma
In this study, we aimed to investigate the effect of siRNA-induced knockdown of FGFR3 on the biological behaviors of intrahepatic cholangiocarcinoma (ICC). The expression levels of FGFR3 were determined in three intrahepatic cholangiocarcinoma cell lines RBE, HUCCT1 and HCCC9810 cell lines by Western blot.
Source: Digestive and Liver Disease - August 20, 2022 Category: Gastroenterology Authors: Yi-hui Chen, Shao-hua Yang, Li-xin Liu, Sheng Hu, Xue-jun Wang, Zhou-jun Liao, Yun-feng Huan, Kai He, Xiao-wen Zhang Tags: Oncology Source Type: research

Alpha-1 Antitrypsin Deficiency Liver Disease
Liver disease in homozygous ZZ alpha-1 antitrypsin (AAT) deficiency occurs due to the accumulation of large quantities of AAT mutant Z protein polymers in the liver. The mutant Z protein folds improperly during biogenesis and is retained within the hepatocytes rather than appropriately secreted. These intracellular polymers trigger an injury cascade, which leads to liver injury. However, the clinical liver disease is highly variable and not all patients with this same homozygous ZZ genotype develop liver disease. Evidence suggests that genetic determinants of intracellular protein processing, among other unidentified genet...
Source: Clinics in Liver Disease - June 24, 2022 Category: Gastroenterology Authors: Anandini Suri, Dhiren Patel, Jeffrey H. Teckman Source Type: research

Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF- κB signaling pathways.
CONCLUSION: AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-κB pathway. Therefore, AITC is a potential therapeutic agent for NAFLD. PMID: 31558861 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 13, 2019 Category: Gastroenterology Authors: Li CX, Gao JG, Wan XY, Chen Y, Xu CF, Feng ZM, Zeng H, Lin YM, Ma H, Xu P, Yu CH, Li YM Tags: World J Gastroenterol Source Type: research

miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1.
CONCLUSION: This study demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1. PMID: 29290651 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Liu XL, Cao HX, Wang BC, Xin FZ, Zhang RN, Zhou D, Yang RX, Zhao ZH, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research

Emerging Concepts and Human Trials in Alpha-1-Antitrypsin Deficiency Liver Disease
Semin Liver Dis 2017; 37: 152-158 DOI: 10.1055/s-0037-1602586In α-1-antitrypsin (AAT) deficiency, individuals homozygous for the AAT mutant Z gene synthesize large quantities of mutant Z protein in the liver, which folds improperly during biogenesis and is retained within the hepatocytes rather than appropriated secreted. This accumulation of mutant Z protein triggers an intracellular injury cascade causing cell death in the population of hepatocytes with the largest accumulations of Z protein. Hepatocellular proliferation, hepatic fibrosis, and hepatocellular cancer in some individuals can be the result. New insights fro...
Source: Seminars in Liver Disease - May 31, 2017 Category: Gastroenterology Authors: Teckman, Jeffrey H. Tags: Review Article Source Type: research

P.05.4: Cancer Progression Control in Inflammatory Bowel Disease: Cyclin D1 and E2F1 Sirna Delivery by New Vectors
Source: Digestive and Liver Disease - March 15, 2017 Category: Gastroenterology Authors: I. Russo, S. Bochicchio, O. Piazza, A.A. Barba, G. Lamberti, A. Carrizzo, P. Zeppa, C. Vecchione, P. Iovino, C. Ciacci Tags: Posters Source Type: research

CD98 siRNA-loaded nanoparticles decrease hepatic steatosis in mice
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid hepatic accumulation. Here, we investigated whether a reduction of CD98 expression mediated by CD98 siRNA-loaded nanoparticles (NPs) could attenuate liver disease markers in a mouse model of NAFLD. NPs were generated using a double emulsion/solvent evaporation technique. Mice fed a high fat diet for 8 weeks to induce fatty liver were treated with vein tail injections of CD98 siRNA-loaded NPs. In vitro, HepG2 treated with CD98 siRNA-loaded NPs showed significant downregulation of CD98 leading to a significant decrease of major pro-inflammatory cytokines and markers.
Source: Digestive and Liver Disease - November 16, 2016 Category: Gastroenterology Authors: Brandon S.B. Canup, Heliang Song, Vu Le Ngo, Xiangxiao Meng, Timothy L. Denning, Pallavi Garg, Hamed Laroui Tags: Liver, Pancreas and Biliary Tract Source Type: research

Long non-coding RNAs era in liver cancer.
Authors: Guerrieri F Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide. HCC is characterized by deregulation of multiple genes and signalling pathways. These genetic effects can involve both protein coding genes as well as non-coding RNA genes. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nt, constituting a subpopulation of ncRNAs. Their biological effects are not well understood compared to small non-coding RNA (microRNAs), but they have been recently recognized to exe...
Source: World Journal of Hepatology - August 12, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatic TLR4 Signaling in Obese NAFLD.
CONCLUSION: TLR4 expression is up-regulated in a large cohort of NASH patients, when compared to those with NAFL, and this occurs within the setting of increased LPS and fatty acids. PMID: 26113297 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - June 25, 2015 Category: Gastroenterology Authors: Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.
CONCLUSION: OPN is a key mediator of the alcohol-induced effects on hepatic stellate cell functions and liver fibrogenesis. PMID: 25278703 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS Tags: World J Gastroenterol Source Type: research

Pages: 1  2