Filtered By:
Specialty: Drugs & Pharmacology
Vaccination: Vaccines
This page shows you your search results in order of date.
Order by Relevance | Date
Total 69 results found since Jan 2013.
Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution
Eur J Pharm Biopharm. 2023 Aug 12:S0939-6411(23)00205-9. doi: 10.1016/j.ejpb.2023.08.002. Online ahead of print.ABSTRACTRNA therapeutics represents a powerful strategy for diseases where other approaches have failed, especially given the recent successes of mRNA vaccines against the coronavirus disease 2019 (COVID-19) and small interfering (siRNA) therapeutics. However, further developments are still required to reduce toxicity, improve stability and biodistribution of mRNA-LNPs (lipid nanoparticles). Here, we show a rational combinatorial approach to select the best formulation based on a new cationic lipid molecule (IM21...
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Claire Gu éguen Thibaut Ben Chimol Margaux Briand Kassandra Renaud M élodie Seiler Morgane Ziesel Patrick Erbacher Malik Hellal Source Type: research
Magnetosomes as Potential Nanocarriers for Cancer Treatment
Curr Drug Deliv. 2023 Jun 19. doi: 10.2174/1567201820666230619155528. Online ahead of print.ABSTRACTMagnetotactic bacteria (MTBs) and their organelles, magnetosomes, are intriguing options that might fulfill the criteria of using bacterial magnetosomes (BMs). The ferromagnetic crystals contained in BMs can condition the magnetotaxis of MTBs, which is common in water storage facilities. This review provides an overview of the feasibility of using MTBs and BMs as nanocarriers in cancer treatment. More evidence suggests that MTBs and BMs can be used as natural nanocarriers for conventional anticancer medicines, antibodies, va...
Source: Current Drug Delivery - June 21, 2023 Category: Drugs & Pharmacology Authors: Rawan Alsharedeh Nid'a Alshraiedeh Alaa A Aljabali Murtaza M Tambuwala Source Type: research
Evolution of Nanomedicine Formulations for Targeted Delivery and Controlled Release
Adv Drug Deliv Rev. 2023 Jun 13:114962. doi: 10.1016/j.addr.2023.114962. Online ahead of print.ABSTRACTNanotechnology research over the past several decades has been aimed primarily at improving the physicochemical properties of small molecules to produce druggable candidates as well as for tumor targeting of cytotoxic molecules. The recent focus on genomic medicine and the success of lipid nanoparticles for mRNA vaccines have provided additional impetus for the development of nanoparticle drug carriers for nucleic acid delivery, including siRNA, mRNA, DNA, and oligonucleotides, to create therapeutics that can modulate pro...
Source: Advanced Drug Delivery Reviews - June 15, 2023 Category: Drugs & Pharmacology Authors: Sanyogitta Puri Mariarosa Mazza Gourgopal Roy Richard M England Liping Zhou Saghar Nourian J Anand Subramony Source Type: research
Novel therapeutic strategies for autoimmune and inflammatory rheumatic diseases
Drug Discov Today. 2023 May 8:103612. doi: 10.1016/j.drudis.2023.103612. Online ahead of print.ABSTRACTDrugs of unknown mechanisms of action are no longer being developed because we have largely capitalized on our improved understanding of the immunopathogenesis of immune-mediated inflammatory diseases (IMIDs) to develop therapeutic monoclonal antibodies (mAbs) and targeted treatments. These therapies have profoundly revolutionized the care of IMIDs. However, because of the heterogeneity of IMIDs and the redundancy of the targeted molecular pathways, some patients with IMIDs might not respond to a specific targeted drug or...
Source: Drug Discovery Today - May 10, 2023 Category: Drugs & Pharmacology Authors: Renaud Felten Philippe Mertz Eden Sebbag Marc Scherlinger Laurent Arnaud Source Type: research
Lipid nanoparticle-mediated drug delivery to the brain
Adv Drug Deliv Rev. 2023 May 5:114861. doi: 10.1016/j.addr.2023.114861. Online ahead of print.ABSTRACTLipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While LNPs have been extensively studied for the delivery of RNA drugs to muscle and liver targets, their potential to deliver drugs to challenging tissue targets such as the brain remains underexplored. Multiple brain disorders currently lack safe and effective therapies and therefore repurposing LNPs could po...
Source: Advanced Drug Delivery Reviews - May 7, 2023 Category: Drugs & Pharmacology Authors: Purva Khare Sara X Edgecomb Christine M Hamadani Eden E L Tanner Devika S Manickam Source Type: research
Self-Assembly of Peptide: Structure, Function, and Advanced Application in Biomedicine
Curr Pharm Des. 2023 Feb 13. doi: 10.2174/1381612829666230213152259. Online ahead of print.ABSTRACTThe self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly were described. And the advances of pep...
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: He Diao Yunhua Lu Yun Ling Yingjie Shen Jingmou Yu Kun Ma Source Type: research
Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic
Biol Pharm Bull. 2023;46(2):301-308. doi: 10.1248/bpb.b22-00746.ABSTRACTmRNA vaccines have attracted considerable attention as a result of the 2019 coronavirus pandemic; however, challenges remain regarding use of mRNA vaccines, including insufficient delivery owing to the high molecular weights and high negative charges associated with mRNA. These characteristics of mRNA vaccines impair intracellular uptake and subsequent protein translation. In the current study, we prepared a minimal mRNA vaccine encoding a tumor associated antigen human gp10025-33 peptide (KVPRNQDWL), as a potential treatment for melanoma. Minimal mRNA...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rabab A Husseini Naoko Abe Tomoaki Hara Hiroshi Abe Kentaro Kogure Source Type: research
