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Specialty: Drugs & Pharmacology
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Total 3220 results found since Jan 2013.
Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA
In this study, we demonstrated a novel strategy to construct negatively charged and ultrasound (US)-responsive O-carboxymethyl chitosan (O-CMS) NDs as a siRNA targeted delivery system through three-way junction of bacteriophage phi29 DNA packaging motor (3WJ-pRNA) nanotechnology. 39nt A10-3.2 aptamer targeting prostate specific membrane antigen (PSMA) and 21nt siRNA against cationic amino acid transporter 1 (siCAT-1) were annealed to 3WJ-pRNA scaffold via complementation with an extended sequence. The cholesterol molecule attached to one branch facilitates the 3WJ-pRNA nanoparticles anchoring onto NDs. The desired O-CMS ND...
Source: Drug Delivery - January 17, 2022 Category: Drugs & Pharmacology Authors: Lu Guo Dandan Shi Mengmeng Shang Xiao Sun Dong Meng Xinxin Liu Xiaoying Zhou Jie Li Source Type: research
Inhibitory Effect of Aptamer-Carbon Dot Nanomaterial-siRNA Complex on the Metastasis of Hepatocellular Carcinoma Cells by Interfering with FMRP
Eur J Pharm Biopharm. 2022 Mar 29:S0939-6411(22)00061-3. doi: 10.1016/j.ejpb.2022.03.013. Online ahead of print.ABSTRACTUsing small interfering RNA (siRNA) for the specific gene-silencing has been a novel therapeutic method for the treatment of incurable diseases such as malignancies. However, it remains a challenge whether siRNA can be safely and effectively delivered into target cells. Therefore, we synthesized fluorescent carbon dots (CDs) as a gene vector at the siRNA delivery system that induced efficient gene knockdown in vitro while binding aptamer AS1411 to resolve the difficulty in cell targeting. We found that CD...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 1, 2022 Category: Drugs & Pharmacology Authors: Xiaoliang Zhao Jie Yang Jing Zhang Xiangyun Wang Lulu Chen Chao Zhang Zhifa Shen Source Type: research
The paradigm of miRNA and siRNA influence in Oral-biome
Biomed Pharmacother. 2023 Jan 20;159:114269. doi: 10.1016/j.biopha.2023.114269. Online ahead of print.ABSTRACTShort nucleotide sequences like miRNA and siRNA have attracted a lot of interest in Oral-biome investigations. miRNA is a small class of non-coding RNA that regulates gene expression to provide effective regulation of post-transcription. On contrary, siRNA is 21-25 nucleotide dsRNA impairing gene function post-transcriptionally through inhibition of mRNA for homologous dependent gene silencing. This review highlights the application of miRNA in oral biome including oral cancer, dental implants, periodontal diseases...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2023 Category: Drugs & Pharmacology Authors: Adrija Sinha Rahul Bhattacharjee Basudha Bhattacharya Aditya Nandi Ramya Shekhar Ankit Jana Koustav Saha Lamha Kumar Swadheena Patro Pritam Kumar Panda Nagendra Kumar Kaushik Mrutyunjay Suar Suresh K Verma Source Type: research
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery
Chem Pharm Bull (Tokyo). 2023;71(3):250-256. doi: 10.1248/cpb.c22-00852.ABSTRACTAmphipathic peptides composed of cationic amino acids and hydrophobic amino acids have cell-penetrating ability and are often used as a delivery tool for membrane-impermeable compounds. Small interfering RNA (siRNAs) are one of the delivery targets for such cell-penetrating peptides (CPPs). Cationic CPPs can associate with anionic siRNAs by electrostatic interactions resulting in the formation of nano-sized complexes, which can deliver siRNAs intracellularly. CPPs containing unnatural amino acids offer promising tools to siRNA delivery. However...
Source: Chemical and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Makoto Oba Mika Shibuya Yuto Yamaberi Hidetomo Yokoo Satoshi Uchida Atsushi Ueda Masakazu Tanaka Source Type: research
