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Ablation of DJ-1 enhances oxidative stress by disturbing the function of mitochondria in epidermal melanocytes
Conclusions: DJ-1 plays a role in maintaining the antioxidative capacity in epidermal melanocytes.
Source: Indian Journal of Dermatology - February 24, 2020 Category: Dermatology Authors: Man Li Fang Wang Juan Du Lijuan Wang Jianzhong Zhang Xiaolan Ding Source Type: research

Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signalling pathway via GSK‐3β inactivation
Abstract Vitiligo is an acquired condition characterized by depigmented, cutaneous lesions that result from the death of pigment‐producing cells, melanocytes. The occurrence of oxidative stress has been proposed as a pathogenetic mechanism for melanocyte degeneration in vitiligo. Therefore, in this study, we investigated the cytoprotective effects of afzelin against oxidative stress and its mechanism of action in human epidermal melanocytes. We found that afzelin significantly inhibited hydrogen peroxide‐induced cell death, cellular reactive oxygen species production and lipid peroxidation in melanocytes. In an antioxi...
Source: Experimental Dermatology - April 11, 2017 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: ORIGINAL ARTICLE Source Type: research

Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signaling pathway via GSK‐3β inactivation
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - December 18, 2016 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: Regular Article Source Type: research

512 ATM significantly protects against oxidative injury in human melanocyte associated with activation of Nrf2 pathway
Vitiligo is a common depigmentation disorder characterized by a loss of functional melanocytes from human epidermis, our previous study showed the increased sensitivity to H2O2-induced oxidative insults of vitiligo melanocytes is due to the dysfunction inNrf2-ARE signaling pathway. Here, we sought to determine the underlying mechanism for the aberrant expression of Nrf2-ARE signaling pathway. We found that transfection with ATM-siRNA leads to a significantly increased cell deathcaused by H2O2 and higher intracellular ROS and MDA levels in melanocytes, but have no effect on melanin synthesis and tyrosinase activity.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: Z. Jian, Q. Zhang Tags: Photobiology and Pigmentation Source Type: research

miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1
In conclusion, our findings suggest that miR-196a-2 polymorphisms can regulate the Tyr levels, which influences the susceptibility of vitiligo.
Source: Archives of Dermatological Research - October 1, 2015 Category: Dermatology Source Type: research

Protease-activated receptor-2 activates NQO-1 via Nrf2 stabilization in keratinocytes
Conclusion: Collectively, PAR-2 activation enhanced nuclear Nrf2 translocation, and PAR-2-mediated Nrf2 activation was attributable to existing Nrf2 stabilization rather than de novo production. Our findings suggest that in addition to induction of inflammation, PAR-2 can play a chemopreventative role via Nrf2 stabilization in keratinocytes.
Source: Journal of Dermatological Science - December 9, 2013 Category: Dermatology Authors: Ji Young Kim, Do Young Kim, Hyojung Son, Yoon Jee Kim, Sang Ho Oh Tags: Regular Articles Source Type: research