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Condition: Vitiligo

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Total 18 results found since Jan 2013.

Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling
Phytother Res. 2022 May 18. doi: 10.1002/ptr.7481. Online ahead of print.ABSTRACTPsoralidin (PSO) is a natural phenolic coumarin extracted from the seeds of Psoralea corylifolia L. Growing preclinical evidence indicates that PSO has anti-inflammatory, anti-vitiligo, anti-bacterial, and anti-viral effects. Growth arrest-specific gene 6 (GAS6) and its receptor, Axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. Notably, the neuroprotective role of the GAS6/Axl axis has been identified in previous studies. We hypothesize that PSO ameliorates cerebral hypoxia/reoxygenation ...
Source: Cell Research - May 18, 2022 Category: Cytology Authors: Wangrui Lei Songdi Wu Aizhen Zhao Zhen Wu Baoping Ding Wenwen Yang Chenxi Lu Xue Wu Xiyang Li Shaofei Zhang Ye Tian Yang Yang Source Type: research

Ablation of DJ-1 enhances oxidative stress by disturbing the function of mitochondria in epidermal melanocytes
Conclusions: DJ-1 plays a role in maintaining the antioxidative capacity in epidermal melanocytes.
Source: Indian Journal of Dermatology - February 24, 2020 Category: Dermatology Authors: Man Li Fang Wang Juan Du Lijuan Wang Jianzhong Zhang Xiaolan Ding Source Type: research

Overexpression of interleukin-20 receptor subunit beta (IL20RB) correlates with cell proliferation, invasion and migration enhancement and poor prognosis in papillary renal cell carcinoma.
Authors: Cui XF, Cui XG, Leng N Abstract Papillary renal cell carcinoma (PRCC) accounts for about 10 percent of all renal cell carcinomas, and the prognosis is poor for people with advanced disease. Interleukin-20 receptor subunit beta (IL20RB) is a single-pass type I membrane protein of the type II cytokine receptor family and is related to the pathogenesis of chronic inflammation and autoimmune diseases, including psoriasis, glaucoma, vitiligo, rheumatoid arthritis, and inflammatory bowel disease. However, little has been reported on IL20RB with respect to cancer, especially in PRCC. Thus, we performed this study...
Source: Journal of Toxicologic Pathology - November 14, 2019 Category: Toxicology Tags: J Toxicol Pathol Source Type: research

HMGB1 deficiency reduces H2 O2 -induced oxidative damage in human melanocytes via the Nrf2 pathway.
In this study, we investigated the role of HMGB1 from melanocytes in the response to oxidative stress and the mechanism involved. We showed that HMGB1 is expressed by primary normal human epidermal melanocytes (NHEMs). H2 O2 treatment increased cytoplasmic translocation and extracellular release of HMGB1. HMGB1 knockdown by small interfering RNA (siRNA) led to decreased apoptosis of NHEMs. HMGB1 inhibition enhanced the expression of Nrf2 and its target genes. The expression of Nrf2 and its downstream antioxidant genes was downregulated after the supernatant of H2 O2 -treated NHEMs was added to HMGB1-deficient cells. HMGB1 ...
Source: J Cell Mol Med - October 19, 2018 Category: Molecular Biology Authors: Mou K, Liu W, Miao Y, Cao F, Li P Tags: J Cell Mol Med Source Type: research

Current non-viral siRNA delivery systems as a promissing treatment of skin diseases.
CONCLUSION: The treatment of skin diseases based on topical delivery of siRNA, which act by inhibiting the expression of target transcripts, offers many potential therapeutic advantages for suppressing genes into the skin. PMID: 30084329 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 7, 2018 Category: Drugs & Pharmacology Authors: Rosa J, Suzuki I, Kravicz M, Caron A, Pupo AV, Praca FG, Bentley MVLB Tags: Curr Pharm Des Source Type: research

In Vitro TyRP-1 Knockdown Based on siRNA Carried by Liquid Crystalline Nanodispersions: an Alternative Approach for Topical Treatment of Vitiligo
ConclusionsWe demonstrated that the liquid crystalline nanodispersions showed promising alternative for the topical treatment of vitiligo due to their physical parameters and ability in knockdown the target protein involved with autoimmune destruction of melanocytes.
Source: Pharmaceutical Research - March 20, 2018 Category: Drugs & Pharmacology Source Type: research

Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signalling pathway via GSK‐3β inactivation
Abstract Vitiligo is an acquired condition characterized by depigmented, cutaneous lesions that result from the death of pigment‐producing cells, melanocytes. The occurrence of oxidative stress has been proposed as a pathogenetic mechanism for melanocyte degeneration in vitiligo. Therefore, in this study, we investigated the cytoprotective effects of afzelin against oxidative stress and its mechanism of action in human epidermal melanocytes. We found that afzelin significantly inhibited hydrogen peroxide‐induced cell death, cellular reactive oxygen species production and lipid peroxidation in melanocytes. In an antioxi...
Source: Experimental Dermatology - April 11, 2017 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: ORIGINAL ARTICLE Source Type: research

Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signaling pathway via GSK‐3β inactivation
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - December 18, 2016 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: Regular Article Source Type: research

512 ATM significantly protects against oxidative injury in human melanocyte associated with activation of Nrf2 pathway
Vitiligo is a common depigmentation disorder characterized by a loss of functional melanocytes from human epidermis, our previous study showed the increased sensitivity to H2O2-induced oxidative insults of vitiligo melanocytes is due to the dysfunction inNrf2-ARE signaling pathway. Here, we sought to determine the underlying mechanism for the aberrant expression of Nrf2-ARE signaling pathway. We found that transfection with ATM-siRNA leads to a significantly increased cell deathcaused by H2O2 and higher intracellular ROS and MDA levels in melanocytes, but have no effect on melanin synthesis and tyrosinase activity.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: Z. Jian, Q. Zhang Tags: Photobiology and Pigmentation Source Type: research

Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt‐Rac1‐FAK‐JNK and ERK signaling pathways
Abstract Vitiligo is a depigmentation disorder characterized by loss of functional melanocytes of the skin epidermis. The pathogenesis of vitiligo remains elusive. The purpose of this study is to investigate the effects of basic fibroblast growth factor (bFGF) on melanocyte migration, including its biochemical mechanism using transwell assay in vitro. We found that melanocyte treated with bFGF showed a significant increase in migration and cytoskeletal rearrangement. These changes were associated with increased activation of PI3K/Akt, Rac1, FAK, JNK, and ERK. Likewise, reduction of PI3K/Akt, Rac1, FAK, JNK, and ERK activit...
Source: IUBMB Life - June 28, 2016 Category: Research Authors: Hongxue Shi, Beibei Lin, Yan Huang, Jiang Wu, Hongyu Zhang, Cai Lin, Zhouguang Wang, Jingjing Zhu, Yingzhen Zhao, Xiaobing Fu, Zhencai Lou, Xiaokun Li, Jian Xiao Tags: Research Communication Source Type: research

Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt ‐Rac1‐FAK‐JNK and ERK signaling pathways
Abstract Vitiligo is a depigmentation disorder characterized by loss of functional melanocytes of the skin epidermis. The pathogenesis of vitiligo remains elusive. The purpose of this study is to investigate the effects of basic fibroblast growth factor (bFGF) on melanocyte migration, including its biochemical mechanism using transwell assay in vitro. We found that melanocyte treated with bFGF showed a significant increase in migration and cytoskeletal rearrangement. These changes were associated with increased activation of PI3K/Akt, Rac1, FAK, JNK, and ERK. Likewise, reduction of PI3K/Akt, Rac1, FAK, JNK, and ERK activit...
Source: IUBMB Life - June 26, 2016 Category: Research Authors: Hongxue Shi, Beibei Lin, Yan Huang, Jiang Wu, Hongyu Zhang, Cai Lin, Zhouguang Wang, Jingjing Zhu, Yingzhen Zhao, Xiaobing Fu, Zhencai Lou, Xiaokun Li, Jian Xiao Tags: Research Communication Source Type: research

FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression.
This article is protected by copyright. All rights reserved. PMID: 27060922 [PubMed - as supplied by publisher]
Source: Pigment Cell and Melanoma Research - April 8, 2016 Category: Cytology Authors: Jung H, Oh ES Tags: Pigment Cell Melanoma Res Source Type: research

Aspirin induces Nrf2‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress
Abstract The removal of hydrogen peroxide (H2O2) by antioxidants has been proven to be beneficial to patients with vitiligo. Aspirin (acetylsalicylic acid, ASA) has antioxidant activity and has great preventive and therapeutical effect in many oxidative stress‐relevant diseases. Whether ASA can protect human melanocytes against oxidative stress needs to be further studied. Here, we investigated the potential protective effect and mechanisms of ASA against H2O2‐induced oxidative injury in human melanocytes. Human melanocytes were pre‐treated with different concentrations of ASA, followed by exposure to 1.0 mM H2O2. Ce...
Source: Journal of Cellular and Molecular Medicine - March 10, 2016 Category: Molecular Biology Authors: Zhe Jian, Lingzhen Tang, Xiuli Yi, Bangmin Liu, Qian Zhang, Guannan Zhu, Gang Wang, Tianwen Gao, Chunying Li Tags: Original Article Source Type: research

Aspirin induces Nrf2-mediated transcriptional activation of haem oxygenase-1 in protection of human melanocytes from H2 O2 -induced oxidative stress.
Abstract The removal of hydrogen peroxide (H2 O2 ) by antioxidants has been proven to be beneficial to patients with vitiligo. Aspirin (acetylsalicylic acid, ASA) has antioxidant activity and has great preventive and therapeutical effect in many oxidative stress-relevant diseases. Whether ASA can protect human melanocytes against oxidative stress needs to be further studied. Here, we investigated the potential protective effect and mechanisms of ASA against H2 O2 -induced oxidative injury in human melanocytes. Human melanocytes were pre-treated with different concentrations of ASA, followed by exposure to 1.0 mM H...
Source: J Cell Mol Med - March 10, 2016 Category: Molecular Biology Authors: Jian Z, Tang L, Yi X, Liu B, Zhang Q, Zhu G, Wang G, Gao T, Li C Tags: J Cell Mol Med Source Type: research

Aspirin induces Nrf2 ‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress
Abstract The removal of hydrogen peroxide (H2O2) by antioxidants has been proven to be beneficial to patients with vitiligo. Aspirin (acetylsalicylic acid, ASA) has antioxidant activity and has great preventive and therapeutical effect in many oxidative stress‐relevant diseases. Whether ASA can protect human melanocytes against oxidative stress needs to be further studied. Here, we investigated the potential protective effect and mechanisms of ASA against H2O2‐induced oxidative injury in human melanocytes. Human melanocytes were pre‐treated with different concentrations of ASA, followed by exposure to 1.0 mM H2O2. Ce...
Source: Journal of Cellular and Molecular Medicine - March 9, 2016 Category: Molecular Biology Authors: Zhe Jian, Lingzhen Tang, Xiuli Yi, Bangmin Liu, Qian Zhang, Guannan Zhu, Gang Wang, Tianwen Gao, Chunying Li Tags: Original Article Source Type: research