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The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma
Drug Deliv. 2023 Dec;30(1):1-13. doi: 10.1080/10717544.2022.2152911.ABSTRACTTemozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties. O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme, which can repair the DNA damage caused by TMZ. A large number of clinical data show that reducing the expression of MGMT can enhance the chemotherapeutic efficacy of TMZ. Therefore, in order to improve the resistance of glioma to TMZ, an angiopep-2 (A2) modified nanoprodrug of polytemozolomide (P(TMZ)n) tha...
Source: Drug Delivery - December 29, 2022 Category: Drugs & Pharmacology Authors: Haoyue Xu Yongkang Zhang Linfeng Li Yanhong Ren Feng Qian Lansheng Wang Hongwei Ma Ankang Quan Hongmei Liu Rutong Yu Source Type: research

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury
In conclusion, 11R-VIVIT administration inhibits IRI-induced NFAT2 activation and prevents AKI-to-CKD progression. Inhibiting NFAT2 may be a promising new therapeutic strategy for preventing renal fibrosis after IR-AKI.PMID:34937917 | DOI:10.1038/s41401-021-00833-y
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Zhi-Yong Xie Wei Dong Li Zhang Meng-Jie Wang Zhen-Meng Xiao Yu-Hua Zhang Wan-Xin Shi Ying Huang Yan Yang Cui-Li Li Lei Fu Xing-Chen Zhao Rui-Zhao Li Zhi-Lian Li Yuan-Han Chen Zhi-Ming Ye Shuang-Xin Liu Zheng Dong Xin-Ling Liang Source Type: research

BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF- κB Pathway During ICH Recovery
Intracerebral hemorrhage (ICH) is a life-threatening type of stroke that lacks effective treatments. The inflammatory response following ICH is a vital response that affects brain repair and organism recovery. The nuclear factor κB (NF-κB) signaling pathway is considered one of the most important inflammatory response pathways and one of its response pathways, the noncanonical NF-κB signaling pathway, is known to be associated with persistent effect and chronic inflammation. NF-κB–inducing kinase (NIK) via the noncanonical NF-κB signaling plays a key role in controlling inflammation. Here, we investigated potential ...
Source: Frontiers in Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Source Type: research

The prognostic value of combiningCD133 and mismatch repair proteinsin patients with colorectal cancer.
Abstract The prognostic value of cancer stem cells (CSCs) is a hot topic in colorectal carcinoma (CRC)research. CD133 has been identified as an important colorectal CSC marker, but its prognostic significance remains controversial. Recently, studies have reported a possible functional link between CSCs and DNA mismatch repair (MMR) system. However, the relationship between CRC stemness and MMR proteins remains little explored, and whether the predictive role of CD133 is affected by MMR proteins is still unknown. The aim of our study is to investigate the influence of MMR proteins on the predictive significance of ...
Source: Clinical and Experimental Pharmacology and Physiology - September 22, 2020 Category: Drugs & Pharmacology Authors: Wang X, Qiu W, Liu H, Li T, Ye H, Li Y, Xu X, Chen P Tags: Clin Exp Pharmacol Physiol Source Type: research

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