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Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits
ConclusionOur study shows that Curosurf® can be used successfully as an adjuvant therapy with small molecule inhibitors for CHOP/Ang2/miR34a. In this study, of the three inhibitors used, miR34a inhibitor seemed to be the most promising compound to combat IMV and hyperoxia-induced lung injury in preterm rabbits.
Source: Frontiers in Physiology - April 8, 2020 Category: Physiology Source Type: research

38-OR Sexual dimorphism in the effect of inflammation on trophoblast function with preeclampsia
Conclusions We find sexual dimorphism in the effect of inflammation on placental miR-210 expression perhaps mediated by the NFκB1 pathway. This may link placental inflammation in preeclampsia to decreased mitochondrial function in pregnancies with a female fetus. Disclosures L. Myatt: None. C. Guo: None. S. Muralimanoharan: None. A. Maloyan: None.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 24, 2015 Category: OBGYN Source Type: research

EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium.
Abstract Prostaglandin (PG) E2 (PGE2) plays a central role in the regulation of smooth muscle contractions. Classically, PGE2 stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammatory pathways. EP2, a Gαs-coupled receptor, is known to mediate its actions via cAMP signaling. However, we have recently shown that EP2 also activates the proinflammatory PG G/H synthase-2 (PGHS-2). Here, we identify the mechanism underlying the ability of EP2 to maintain uterine quiescence and ...
Source: Endocrinology - November 21, 2013 Category: Endocrinology Authors: Kandola MK, Sykes L, Lee YS, Johnson MR, Hanyaloglu AC, Bennett PR Tags: Endocrinology Source Type: research