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Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury
CONCLUSION: We demonstrated that rapamycin attenuated podocyte apoptosis via upregulation of nestin expression through the mTOR/P70S6K signaling pathway in an Ang II-induced podocyte injury.PMID:35149934 | DOI:10.1007/s11033-021-07029-x
Source: Molecular Biology Reports - February 12, 2022 Category: Molecular Biology Authors: Huimin Shi Yajie Zhao Tiantian He Xianli Wen Gaoting Qu Shanwen Li Weihua Gan Aiqing Zhang Source Type: research

Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway
Conclusions: Using loss/gain-of function method, we demonstrated that miR-421/FOXO3a is the direct target of circHIPK3, and UMSC-Exo prevent ischemic injury by releasing circHIPK3, which in turn down regulate miR-421, resulting in increased expression of FOXO3a, leading to inhibition of pyroptosis and release of IL-1β and IL-18.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Bing Yan, Yu Zhang, Chun Liang, Bin Liu, Fengzhi Ding, Yanli Wang, Bao Zhu, Ranzun Zhao, Xi-Yong Yu, Yangxin Li Tags: Research Paper Source Type: research

Liver-specific Bid silencing inhibits APAP-induced cell death in mice
In conclusion, the liver-specific silencing of Bid expression did not protect APAP-exposed mice from microcirculatory dysfunction, but markedly protected the liver from necrotic cell death and in consequence from sterile inflammation. The study contributes to the understanding of the molecular mechanism of the APAP-induced pathogenic pathway by strengthening the importance of Bid and Bid silencing associated effects.
Source: Apoptosis - September 30, 2019 Category: Molecular Biology Source Type: research

FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission
Publication date: July 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1864, Issue 7Author(s): Yundi Shi, Shengjun Fan, Di Wang, Tianru Huyan, Jinwen Chen, Jiyun Chen, Jing Su, Xin Li, Zhuofei Wang, Shiyu Xie, Caihong Yun, Xuejun Li, Lu TieAbstractDiabetes-induced endothelial cell (EC) dysfunction and neovascularization impairment constitute vascular complications with limited treatment regimens. Transcription factor FOXO1 is a key angiogenic regulator and plays a pathologic role in progression of diabetes. The present study was designed to determine the involvement of FOXO1 in impaired...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - July 10, 2018 Category: Molecular Biology Source Type: research

Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury
Abstract Acute liver failure (ALF) is a life threatening disease for which only few treatment options exist. The molecular pathways of disease progression are not well defined, but the death receptor Fas (CD95/Apo-1) appears to play a pivotal role in hepatocyte cell death and the development of ALF. Here, we explored posttranscriptional gene silencing of Fas by RNAi to inhibit pathophysiological gene expression. For targeting Fas expression in mice, Fas siRNA was formulated with the liver-specific siRNA delivery system DBTC. Treatment of mice with DBTC/siRNAFas reduced Fas expression in the liver, but not in the ...
Source: Apoptosis - January 20, 2015 Category: Molecular Biology Source Type: research