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Total 79 results found since Jan 2013.

Effect of SH2B1 on glucose metabolism during pressure overload-induced cardiac hypertrophy and cardiac dysfunction
This study mainly explored the effect and mechanism of Src homology 2 (SH2) B adaptor protein 1 (SH2B1) on cardiac glucose metabolism during pressure overload-induced cardiac hypertrophy and dysfunction. A pressure-overloaded cardiac hypertrophy model was constructed, and SH2B1-siRNA was injected through the tail vein. Haematoxylin and eosin (H&E) staining was used to detect myocardial morphology. ANP, BNP, β-MHC and the diameter of myocardial fibres were quantitatively measured to evaluate the degree of cardiac hypertrophy, respectively. GLUT1, GLUT4, and IR were detected to assess cardiac glucose metabolism. Cardiac...
Source: Clinical and Experimental Pharmacology and Physiology - July 4, 2023 Category: Drugs & Pharmacology Authors: Beilei Liu Xuguang Liu Shan Hu Shuai Mao Manqi Yang Bin Wu Gang Wu Source Type: research

Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis
ConclusionOur findings demonstrated for the first time that P-Rex1 was an essential signaling mediator in CFs activation and subsequent cardiac fibrosis, and 1A-116 could be a potential pharmacological development drug.
Source: Cardiovascular Drugs and Therapy - March 9, 2023 Category: Cardiology Source Type: research

Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice
by Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu Nutrients are actively taken up by the brain via various transporters at the blood–brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To compensate for decreased brain DHA, orally supplied DHA must be transported from the circulating blood to the brain across the BBB through transport carriers, including major facilitator superfamily domain-containing protein 2a (MFSD2...
Source: PLoS One - February 16, 2023 Category: Biomedical Science Authors: Takuro Iwao Source Type: research

Upregulated ClC3 channels/transporters elicit swelling-activated Cl < sup > - < /sup > currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension
Biol Pharm Bull. 2022 Aug 20. doi: 10.1248/bpb.b22-00513. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by vascular remodeling of the pulmonary artery, which is mainly attributed to the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) comprising the medial layer of pulmonary arteries. The activity of ion channels associated with cytosolic Ca2+ signaling regulates the pathogenesis of PAH. Limited information is currently available on the role of Cl- channels in PASMCs. Therefore, the functional expression of ClC3 channels/transporters was herein investigated i...
Source: Biological and Pharmaceutical Bulletin - August 21, 2022 Category: Drugs & Pharmacology Authors: Taiki Amano Aya Yamamura Moe Fujiwara Seiji Hirai Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research

Delivering siRNA Compounds During HOPE to Modulate Organ Function: A Proof-of-concept Study in a Rat Liver Transplant Model
Conclusions. FAS inhibition through siRNA therapy decreases the severity of IRI after LT in a SCS protocol; however the association of siRNA therapy with a HOPE perfusion model is very challenging. Future studies using better designed siRNA compounds and appropriate doses are required to prove the siRNA therapy effectiveness during liver HOPE liver perfusion.
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research

Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway
The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in myocardial I/R injury. We hypothesized that propofol prevents myocardial I/R injury by inhibiting ferroptosis via the AKT/p53 signaling pathway. The ferroptosis-inducing agent erastin (E) and AKT inhibitor MK2206 (MK) were used to investigate the role of propofol in myocardial I/R injury. H9C2 cells treated without any reagents, erastin for 24 h, propofol for 1 h before adding erastin were as...
Source: Frontiers in Pharmacology - March 16, 2022 Category: Drugs & Pharmacology Source Type: research

Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury
CONCLUSION: We demonstrated that rapamycin attenuated podocyte apoptosis via upregulation of nestin expression through the mTOR/P70S6K signaling pathway in an Ang II-induced podocyte injury.PMID:35149934 | DOI:10.1007/s11033-021-07029-x
Source: Molecular Biology Reports - February 12, 2022 Category: Molecular Biology Authors: Huimin Shi Yajie Zhao Tiantian He Xianli Wen Gaoting Qu Shanwen Li Weihua Gan Aiqing Zhang Source Type: research