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Procedure: Anesthesia
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Total 123 results found since Jan 2013.
Neuroprotective effect of dexmedetomidine pretreatment on sevoflurane-initiated neurotoxicity via the miR-204-5p/SOX4 axis
CONCLUSION: Dex pretreatment decreased miR-204-5p expression levels and upregulated SOX4 expression levels, palliating Sev-initiated neurotoxicity.PMID:37259215 | DOI:10.2174/0929866530666230530164913
Source: Protein and Peptide Letters - June 1, 2023 Category: Biochemistry Authors: Run Wang Pengfei Liu Fan Li Hui Qiao Source Type: research
Low-dose ketamine inhibits neuronal apoptosis and neuroinflammation in PC12 cells via α7nAChR mediated TLR4/MAPK/NF-κB signaling pathway
Int Immunopharmacol. 2023 Feb 24;117:109880. doi: 10.1016/j.intimp.2023.109880. Online ahead of print.ABSTRACTKetamine is commonly used for sedation, analgesia and anesthetics. Much evidence has shown that it has an immune-regulatory effect. The cholinergic anti-inflammatory pathway mediated by α7nAChR is a prominent target of anti-inflammatory therapy. However, whether ketamine suppresses inflammatory levels in nerve cells by activating α7nAChR remains unknown. Lipopolysaccharide (LPS) was used to establish the neuroinflammation model in PC12 cells in vitro, and α7nAChR siRNA was transfected into PC12 cells 30 min befo...
Source: International Immunopharmacology - February 26, 2023 Category: Allergy & Immunology Authors: Jinghua Zhao Ruxin Zhang Wei Wang Sheng Jiang Huimei Liang Chen Guo Jingyi Qi Huan Zeng Houhui Song Source Type: research
γ-Aminobutyric Acid-Ergic Development Contributes to the Enhancement of Electroencephalogram Slow-Delta Oscillations Under Volatile Anesthesia in Neonatal Rats
CONCLUSIONS: Enhancement of cortical EEG slow-delta oscillations by volatile anesthetics may require mature GABAergic inhibitory transmission during neonatal development.PMID:36753442 | DOI:10.1213/ANE.0000000000006396
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Mingyue Zhang Yali Chen Ting Xu Jingyao Jiang Donghang Zhang Han Huang Charles D Kurth Ian Yuan Rurong Wang Jin Liu Tao Zhu Cheng Zhou Source Type: research
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain
CONCLUSIONS: pRSK2/JMJD3/H3K27me3/TRPV1 signaling in the DRG neurons plays as a key regulator for PTX therapeutic approaches.PMID:36753440 | DOI:10.1213/ANE.0000000000006397
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Ming-Chun Hsieh Cheng-Yuan Lai Wen-Long Cho Li-Ting Lin Chou-Ming Yeh Po-Sheng Yang Jen-Kun Cheng Hsueh-Hsiao Wang Kuan-Hung Lin Siao-Tong Nie Tzer-Bin Lin Hsien-Yu Peng Source Type: research
γ-Aminobutyric Acid-Ergic Development Contributes to the Enhancement of Electroencephalogram Slow-Delta Oscillations Under Volatile Anesthesia in Neonatal Rats
CONCLUSIONS: Enhancement of cortical EEG slow-delta oscillations by volatile anesthetics may require mature GABAergic inhibitory transmission during neonatal development.PMID:36753442 | DOI:10.1213/ANE.0000000000006396
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Mingyue Zhang Yali Chen Ting Xu Jingyao Jiang Donghang Zhang Han Huang Charles D Kurth Ian Yuan Rurong Wang Jin Liu Tao Zhu Cheng Zhou Source Type: research
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain
CONCLUSIONS: pRSK2/JMJD3/H3K27me3/TRPV1 signaling in the DRG neurons plays as a key regulator for PTX therapeutic approaches.PMID:36753440 | DOI:10.1213/ANE.0000000000006397
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Ming-Chun Hsieh Cheng-Yuan Lai Wen-Long Cho Li-Ting Lin Chou-Ming Yeh Po-Sheng Yang Jen-Kun Cheng Hsueh-Hsiao Wang Kuan-Hung Lin Siao-Tong Nie Tzer-Bin Lin Hsien-Yu Peng Source Type: research
Role of Tumor Necrosis Factor Receptor 1-Reactive Oxygen Species-Caspase 11 Pathway in Neuropathic Pain Mediated by HIV gp120 With Morphine in Rats
CONCLUSIONS: These results suggest that spinal TNFRI-mtROS-caspase 11 signal pathway plays a critical role in the HIV-associated neuropathic pain state, providing a novel approach to treating chronic pain in PLWH with opioids.PMID:36662639 | DOI:10.1213/ANE.0000000000006335
Source: Anesthesia and Analgesia - January 20, 2023 Category: Anesthesiology Authors: Kentaro Hayashi Hyun Yi Xun Zhu Shue Liu Jun Gu Keiya Takahashi Yuta Kashiwagi Marta Pardo Hirotsugu Kanda Heng Li Roy C Levitt Shuanglin Hao Source Type: research
Function of connexin 43 and RhoA/LIMK2/Cofilin signaling pathway in transient changes of contraction and dilation of human umbilical arterial smooth muscle cells
CONCLUSION: The function of Cx43-GJs lies in the center of Ang Ⅱ-induced contraction of HUASMCs, which potentially regulates intracellular Ca2+ mobility as well as RhoA/LIMK2/Cofilin signaling pathway activity. Propofol can reverse this effect induced by Ang Ⅱ through suppressing the function of Cx43-GJs.PMID:36330887 | DOI:10.1016/j.biocel.2022.106326
Source: The International Journal of Biochemistry and Cell Biology - November 4, 2022 Category: Biochemistry Authors: Zhizhao Deng Yanling Zhang Qian Zhang Xianlong Li Weiqi Zeng Cai Jun Dongdong Yuan Source Type: research
