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Total 40893 results found since Jan 2013.
FOXO1 regulates NLRP3 inflammasome proteins in LPS-induced cardiotoxicity
CONCLUSION: FOXO1 overexpression attenuated apoptosis, ROS generation, and inflammation, whereas FOXO1 inhibition aggravated LPS-induced cardiomyocyte injury via the NLRP3 inflammasome signaling pathway.PMID:37692952 | PMC:PMC10492091
Source: American Journal of Translational Research - September 11, 2023 Category: Research Authors: Hui Zhao Lingcun Qin Ruyi Wang Dejie Qu Suting Li Source Type: research
GSE242255 DNA-PKcs is a key transcriptional and splicing regulator of AR-Vs in advanced prostate cancer
Contributors : Luke Gaughan ; Beth Adamson ; Nicholas BrittainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of DNA-PKcs and RBMX in the regulation of androgen receptor variants we used the CWR22Rv1-AR-EK and CWR22Rv1 cell line in which DNA-PKcs or RBMX has been knocked down by siRNA or DNA-PKcs was inhibited with 1 µM NU7441, NU5455 or AZD7648. We then performed gene expression analysis using data obtained from RNA-seq at two time points (72 hours knockdown and 24 hours drug treatment).
Source: GEO: Gene Expression Omnibus - September 11, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
AbstractFLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular development and vessel homeostasis. Although a soluble isoform, sFLT1, is often mis-regulated in disease and aging, how sFLT1 is trafficked and secreted from endothelial cells is not well understood. Here we define requirements for constitutive sFLT1 trafficking and secretion in endothelial cells from the Golgi to the plasma membrane, and we show that sFLT1 secretion requires clathrin at or near the Golgi. Perturbations that affect sFLT1 trafficking blunted endothelial cell secretion and promoted intrac...
Source: Angiogenesis - September 11, 2023 Category: Molecular Biology Source Type: research
GRK2 expression and catalytic activity are essential for vasoconstrictor / ERK-stimulated arterial smooth muscle proliferation
Biochem Pharmacol. 2023 Sep 8:115795. doi: 10.1016/j.bcp.2023.115795. Online ahead of print.ABSTRACTProlonged vasoconstrictor signalling found in hypertension, increases arterial contraction, and alters vessel architecture by stimulating arterial smooth muscle cell (ASMC) growth, underpinning the development of re-stenosis lesions and vascular remodelling. Vasoconstrictors interact with their cognate G protein coupled receptors activating a variety of signalling pathways to promote smooth muscle proliferation. Here, angiotensin II (AngII) and endothelin 1 (ET1), but not UTP stimulates ASMC proliferation. Moreover, siRNA-me...
Source: Biochemical Pharmacology - September 10, 2023 Category: Drugs & Pharmacology Authors: Asma Alonazi Craig A Nash Chuan-Han Wang Elena Christofidou R A John Challiss Jonathon M Willets Source Type: research
FUS regulates the alternative splicing of cell proliferation genes related to atherosclerosis
Exp Biol Med (Maywood). 2023 Sep 9:15353702231187642. doi: 10.1177/15353702231187642. Online ahead of print.ABSTRACTFUS plays a significant role as an RNA-binding protein in several cellular processes, including RNA splicing, DNA repair, and transcriptional regulation. However, the RNA-binding capacity of FUS in atherosclerosis is unclear. We aimed to study the functions of FUS in inflammatory regulation through the role of the splicing factor. We knocked down FUS with siRNA to further study the overall transcriptional level and select alternative splicing (AS) of FUS regulation in human umbilical vein endothelial cells (H...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Jianjun Hou Shaobing Yang Ying Guo Ning Yan Shaobin Jia Source Type: research
GSE103987 MAP3K8 is a major regulator of inflammation in human airway epithelial cells
Contributors : Chih-Yung Chiu ; Saffron A Willis-Owen ; Kenny C Wong ; Stuart N Farrow ; Youming Zhang ; Miriam F Moffatt ; William O CooksonSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn this experiment we catalogue temporal variation in transcription occurring during IL1B stimulation under control (non-targeting siRNA control) conditions and partial MAP3K8 siRNA knockdown in the A549 cell line. We measure global gene transcription at 0, 1, 2, 4, 6, 8, and 12 hours using Affymetrix HuGene 1.1 ST array. Nineteen genes demonstrated a distinct temporal response to Il1B stimulation following suppression of MAP3K8.
Source: GEO: Gene Expression Omnibus - September 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Positive Topline Results for Antihypertensive Zilebesiran Positive Topline Results for Antihypertensive Zilebesiran
The investigational siRNA therapeutic showed consistent and sustained reductions in systolic blood pressure in a phase 2 study of adults with hypertension.Medscape Medical News
Source: Medscape Cardiology Headlines - September 8, 2023 Category: Cardiology Tags: Cardiology News Source Type: news
BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway
CONCLUSIONS: This finding demonstrated that BOP1 promoted CaP progression by regulating the DUSP6/MAPK pathway.PMID:37681336 | DOI:10.56434/j.arch.esp.urol.20237606.54
Source: Archivos Espanoles de Urologia - September 8, 2023 Category: Urology & Nephrology Authors: Xiaoqing Wu Zheng Jing Tianpu Huang Yongsheng Jing Source Type: research
RACK1 mediates NLRP3 inflammasome activation during Pasteurella multocida infection
This study shows that RACK1 expression was downregulated by PmCQ2 infection in primary mouse peritoneal macrophages and mouse tissues, and overexpression of RACK1 prevented PmCQ2-induced cell death and reduced the numbers of adherent and invasive PmCQ2, indicating a modulatory role of RACK1 in the cell death that is induced by P. multocida infection. Next, RACK1 knockdown by siRNA significantly attenuated PmCQ2-induced NLRP3 inflammasome activation, which was accompanied by a reduction in the protein expression of interleukin (IL)-1β, pro-IL-1β, caspase-1 and NLRP3 as well as the formation of ASC specks, while RACK1 over...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Jinrong Ran Hang Yin Yating Xu Yu Wang Gang Li Xingping Wu Lianci Peng Yuanyi Peng Rendong Fang Source Type: research
