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Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells
Acta Pharmacol Sin. 2021 May 25. doi: 10.1038/s41401-021-00691-8. Online ahead of print.ABSTRACTThe tumor suppressor p53 is usually inactivated by somatic mutations in malignant neoplasms, and its reactivation represents an attractive therapeutic strategy for cancers. Here, we reported that a new quinolone compound RYL-687 significantly inhibited non-small cell lung cancer (NSCLC) cells which express wild type (wt) p53, in contract to its much weaker cytotoxicity on cells with mutant p53. RYL-687 upregulated p53 in cells with wt but not mutant p53, and ectopic expression of wt p53 significantly enhanced the anti-NSCLC acti...
Source: Acta Pharmacologica Sinica - May 26, 2021 Category: Drugs & Pharmacology Authors: Hong Yu Hong-Ying Gao Hua Guo Gui-Zhen Wang Yi-Qing Yang Qian Hu Li-Jun Liang Qun Zhao Da-Wei Xie Yu Rao Guang-Biao Zhou Source Type: research

Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve
This study describes, for the first time, the existence of sub-populations of primordial follicles on the basis of K8/K18 expression in granulosa cells, and that their proportions change with age. While a progressive increase in K8/K18 expression cannot be ruled out, our data are consistent with the hypothesis that primordial follicles expressing low levels of K8/K18 are preferentially ablated by follicle attrition, while primordial follicles showing high K8/K18 levels are those predominantly recruited into the growing pool. This suggests that K8/K18 expression could constitute a novel factor regulating primordial follicle...
Source: Human Reproduction - February 1, 2018 Category: Reproduction Medicine Source Type: research

HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation.
Authors: Yan J, Ma C, Cheng J, Li Z, Liu C Abstract HS1 associated protein X-1 (HAX-1), a substrate of Src family tyrosine kinases, plays a critical role in cell apoptosis. However, its functions in prostate cancer remains unclear. The present study explored the role and mechanism of HAX-1 in cancer cell apoptosis. The mRNA and protein levels of HAX-1 in the prostate cancer cell lines PC-3, VCaP and DU145 were assessed. Cell proliferation, apoptosis and caspase-9 activities were assessed in DU145 after HAX-1 siRNA treatment. The mRNA and protein levels of HAX-1 in prostate cancer cell lines PC-3, VCaP and DU145 wer...
Source: Oncology Reports - September 3, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Matrix metalloproteinase-9 activates TGF-{beta} and stimulates fibroblast contraction of collagen gels
This study provides direct evidence that endogenously produced MMP-9 has a role in regulation of tissue contraction of 3D collagen gels mediated by fibroblasts.
Source: AJP: Lung Cellular and Molecular Physiology - June 1, 2014 Category: Respiratory Medicine Authors: Kobayashi, T., Kim, H., Liu, X., Sugiura, H., Kohyama, T., Fang, Q., Wen, F.-Q., Abe, S., Wang, X., Atkinson, J. J., Shipley, J. M., Senior, R. M., Rennard, S. I. Tags: ARTICLES Source Type: research

Matrix metalloproteinase-9 activates TGF-ss and stimulates fibroblast contraction of collagen gels.
This study provides direct evidence that endogenously produced MMP-9 has a role in regulation of tissue contraction of 3-dimensional collagen gels mediated by fibroblasts. PMID: 24705725 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 4, 2014 Category: Cytology Authors: Kobayashi T, Kim H, Liu X, Sugiura H, Kohyama T, Fang Q, Wen FQ, Abe S, Wang X, Atkinson JJ, Shipley JM, Senior RM, Rennard SI Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts.
We report that, while human BM-MSCs retain pluripotency, they adopt a myofibroblastic phenotype in culture and stain positive for the myofibroblast markers α-SMA, vimentin, NMMIIB, ED-A fibronectin, and collagen type 1 at each passage. In addition, they contract collagen gels in response to TGF-β1 and synthesize collagen similar to human CMyfbs. Moreover, inhibition of NMMII activity with blebbistatin completely attenuates gel contractility without affecting cell viability. Thus, human BM-MSCs share and exhibit similar physiological and functional characteristics as human CMyfbs in vitro, and their propensity to adopt a ...
Source: Molecular and Cellular Biochemistry - April 2, 2014 Category: Biochemistry Authors: Ngo MA, Müller A, Li Y, Neumann S, Tian G, Dixon IM, Arora RC, Freed DH Tags: Mol Cell Biochem Source Type: research