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Total 121 results found since Jan 2013.

Clinical pharmacology of siRNA therapeutics: current status and future prospects
Expert Rev Clin Pharmacol. 2022 Oct 17. doi: 10.1080/17512433.2022.2136166. Online ahead of print.ABSTRACTINTRODUCTION: Small interfering RNA (siRNA) has emerged as a powerful tool for post-transcriptional downregulation of multiple genes for various therapies. Naked siRNA molecules are surrounded by several barriers that tackle their optimum delivery to target tissues such as limited cellular uptake, short circulation time, degradation by endonucleases, glomerular filtration, and capturing by the reticuloendothelial system (RES).AREAS COVERED: This review provides insights into studies that investigate various siRNA-based...
Source: Expert Review of Clinical Pharmacology - October 17, 2022 Category: Drugs & Pharmacology Authors: Ahmed Khaled Abosalha Jacqueline Boyajian Waqar Ahmad Paromita Islam Merry Ghebretatios Sabrina Schaly Rahul Thareja Karan Arora Satya Prakash Source Type: research

Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
Infect Genet Evol. 2021 Jun 2:104951. doi: 10.1016/j.meegid.2021.104951. Online ahead of print.ABSTRACTThe devastating outbreak of COVID-19 has spread all over the world and has become a global health concern. There is no specific therapeutics to encounter the COVID-19. Small interfering RNA (siRNA)-based therapy is an efficient strategy to control human viral infections employing post-transcriptional gene silencing (PTGS) through neutralizing target complementary mRNA. RNA-dependent RNA polymerase (RdRp) encoded by the viral RdRp gene as a part of the replication-transcription complex can be adopted as an acceptable targe...
Source: Infection, Genetics and Evolution - June 5, 2021 Category: Genetics & Stem Cells Authors: Mohammad Mahfuz Ali Khan Shawan Ashish Ranjan Sharma Manojit Bhattacharya Bidyut Mallik Farhana Akhter Md Salman Shakil Md Mozammel Hossain Subrata Banik Sang-Soo Lee Md Ashraful Hasan Chiranjib Chakraborty Source Type: research

Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach
In this study, we attempted to design a siRNA molecule to silence the most suitable nucleocapsid(N) gene of SARS-CoV-2, which play a major role during viral pathogenesis, replication, encapsidation and RNA packaging. At first, 270 complete N gene sequences of different strains in Bangladesh of these viruses were retrieved from the NCBI database. Different computational methods were used to design siRNA molecules. A siRNA molecule was built against these strains using the SiDirect 2.0 server. Using Mfold and the OligoCalc server, the siRNA molecule was tested for its secondary structure and GC material. The Clustal Omega to...
Source: Computational Biology and Chemistry - May 13, 2021 Category: Bioinformatics Authors: Syed Shahariar Bappy Abu Zaffar Shibly Sorna Sultana A K M Mohiuddin Yearul Kabir Source Type: research

A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein gene of SARS-CoV-2.
Abstract An outbreak, caused by an RNA virus, SARS-CoV-2 named COVID-19 has become pandemic with a magnitude which is daunting to all public health institutions in the absence of specific antiviral treatment. Surface glycoprotein and nucleocapsid phosphoprotein are two important proteins of this virus facilitating its entry into host cell and genome replication. Small interfering RNA (siRNA) is a prospective tool of the RNA interference (RNAi) pathway for the control of human viral infections by suppressing viral gene expression through hybridization and neutralization of target complementary mRNA. So, in this stu...
Source: Genomics - December 12, 2020 Category: Genetics & Stem Cells Authors: Chowdhury UF, Shohan MUS, Hoque KI, Beg MA, Siam MKS, Moni MA Tags: Genomics Source Type: research

siRNA as a potential therapy for COVID-19
Curr Drug Deliv. 2021 Aug 5. doi: 10.2174/1567201818666210805145320. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious virus causing COVID-19 disease that severely impacted the world health, education, and economy systems in 2020. The numbers of infection cases and reported deaths are still increasing with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments are under preclinical and clinical investigations now, alongside the race to vaccinate to as much individuals as possible. The genome of SARS-CoV2 share similar...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Ahmad Aljaberi Eman M Migdadi Khalid M Abu Khadra Mahmoud Abu Samak Iman A Basheti Nizar Al-Zoubi Source Type: research