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Total 146 results found since Jan 2013.

Bioinformatics analyses show dysregulation of calcium-related genes in Angelman syndrome mouse model.
Abstract BACKGROUND: Angelman syndrome (AS) is a genetic neurodevelopmental disorder caused by the loss of function of the UBE3A protein in the brain. In a previous study, we showed that activity-dependent calcium dynamics in hippocampal CA1 pyramidal neurons of AS mice is compromised, and its normalization rescues the hippocampal-dependent deficits. Therefore, we expected that the expression profiles of calcium-related genes would be altered in AS mice hippocampi. METHODS: We analyzed mRNA sequencing data from AS model mice and WT controls in light of the newly published CaGeDB database of calcium-related ge...
Source: Neurobiology of Disease - November 16, 2020 Category: Neurology Authors: Panov J, Kaphzan H Tags: Neurobiol Dis Source Type: research

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
This study was mainly conducted in primary human endometrial stromal cells. Therefore, the function of FPNin vivo need to be further investigated.WIDER IMPLICATIONS OF THE FINDINGSOur findings reveal that erastin may serve as a potential therapeutic treatment for endometriosis.STUDY FUNDING/COMPETING INTEREST(S)This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors declare no conflict of interest.
Source: Human Reproduction - December 30, 2020 Category: Reproduction Medicine Source Type: research

Leptin enhances hepatic fibrosis and inflammation in a mouse model of cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions such as cholestasis is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody (Leptin-Ab) on biliary hyperplasia, hepatic fibrosis and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed...
Source: The American Journal of Pathology - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions, such as cholestasis, is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody on biliary hyperplasia, hepatic fibrosis, and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed by quant...
Source: The American Journal of Pathology - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

Transcriptomic and small RNA response to Mayaro virus infection in < i > Anopheles stephensi < /i > mosquitoes
In this study we detail the transcriptomic and small RNA responses ofAn.stephensi to infection with MAYV via infectious bloodmeal at 2, 7, and 14 days post infection (dpi). 487 unique transcripts were significantly regulated, 78 putative novel miRNAs were identified, and an siRNA response is observed targeting the MAYV genome. Gene ontology analysis of transcripts regulated at each timepoint shows a number of proteases regulated at 2 and 7 dpi, potentially representative of Toll or melanization pathway activation, and repression of pathways related to autophagy and apoptosis at 14 dpi. These findings provide a basic unders...
Source: PLoS Neglected Tropical Diseases - June 28, 2022 Category: Tropical Medicine Authors: Cory Henderson Source Type: research