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Source: Molecular Nutrition and Food Research
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Total 20 results found since Jan 2013.

Butyrate Improves Porcine Endometrial Epithelial Cell Receptivity via Enhancing Acetylation of Histone H3K9
ConclusionThe findings reveal that butyrate improves endometrial epithelial cell receptivity by enhancing the acetylation of histone H3K9, which shows nutritional regulation and therapeutic potential for poor uterine receptivity and difficulty in embryo implantation.
Source: Molecular Nutrition and Food Research - July 8, 2023 Category: Food Science Authors: Qianhong Ye, Haoyu Li, Baoyang Xu, Ziyi He, Xianghua Yan Tags: Research Article Source Type: research

Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression
ConclusionThese results indicate that FXR-induced decrease in SESN2 expression and activation of the mTORC1 pathway could control autophagy and be explored as potential therapeutic targets for enterohepatic and metabolic disorders.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 31, 2023 Category: Food Science Authors: GuoYan Wang, Lei Chen, SenLin Qin, HuiJun Geng, Chao Xia, YiNing Zheng, XinJian Lei, Jun Zhang, ShengRu Wu, JunHu Yao, Lu Deng Tags: Research Article Source Type: research

Cystine induced ‐mTORC2 activation through promoting Sin1 phosphorylation to suppress cancer cell ferroptosis
Conclusion: These results indicate that cystine-induced activation of the p38-Sin1-mTORC2-AKT pathway suppresses ferroptosis.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - October 3, 2022 Category: Food Science Authors: GuoYan Wang, Lei Chen, SenLin Qin, YiNing Zheng, Chao Xia, JunHu Yao, Ping Wang, Lu Deng Tags: Research Article Source Type: research

MYO ‐Inositol In Fermented Sugar Matrix Improves Human Macrophage Function
ConclusionThese observations indicate thatmyo-inositol in FPP influences multiple aspects of macrophage function critical for host defense against invading pathogens.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 24, 2022 Category: Food Science Authors: Nandini Ghosh, Amitava Das, Nirupam Biswas, Sanskruti P. Mahajan, Amit K. Madeshiya, Savita Khanna, Chandan K. Sen, Sashwati Roy Tags: Research Article Source Type: research

Organic Cation Transporter I and Na+/taurocholate Co ?Transporting Polypeptide are Involved in Retrorsine? and Senecionine?Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirm previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.
Source: Molecular Nutrition and Food Research - December 11, 2021 Category: Food Science Authors: Anne ?Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Ptz, Albert Braeuning, Stefanie Hessel?Pras Tags: Research Article Source Type: research

Organic Cation Transporter I and Na+/taurocholate Co ‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirmed previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - November 26, 2021 Category: Food Science Authors: Anne ‐Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning, Stefanie Hessel‐Pras Tags: Research Article Source Type: research

Improved Glucose Intolerance Through a Distinct Mouse Olfactory Receptor 23 ‐Induced Signaling Pathway Mediating Glucose Uptake In Myotubes and Adipocytes
ConclusionsThese findings suggest that MOR23 is a novel factor for the regulation of glucose uptake and whole ‐body glucose homeostasis and has therapeutic potential for diabetes treatment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - September 10, 2020 Category: Food Science Authors: Wesuk Kang, Kelun Zhang, Tao Tong, Taesun Park Tags: Research Article Source Type: research

Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch, Madhuri S Salker Tags: Research Article Source Type: research

Epigallocatechin Gallate Induces Upregulation of LDL Receptor via the 67  kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.
Source: Molecular Nutrition and Food Research - February 5, 2020 Category: Food Science Authors: Kumiko Zanka, Yuya Kawaguchi, Yudai Okada, Satoshi Nagaoka Tags: Research Article Source Type: research

Epigallocatechin Gallate Induces Up ‐Regulation of LDL Receptor via the 67 kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Kumiko Zanka, Yuya Kawaguchi, Yudai Okada, Satoshi Nagaoka Tags: Research Article Source Type: research

Gut metabolite, Urolithin A decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUrolithin A leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary Urolithin A in cancer prevention or as adjuvant therapy is promising.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch1, Madhuri S Salker Tags: Research Article Source Type: research

Punicalagin, a Pomegranate ‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
ConclusionsPCG ameliorated obesity and obesity ‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - August 23, 2019 Category: Food Science Authors: Bobin Kang, Chae Young Kim, Jisu Hwang, Kyungae Jo, Singeun Kim, Hyung Joo Suh, Hyeon ‐Son Choi Tags: Research Article Source Type: research

Attenuation of Palmitic Acid –Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protects hepatocytes from FFA ‐induced lipotoxicity through activation of SIRT1, which reverses the oxidative stress and dysfunction of mitochondrial biogenesis directly.
Source: Molecular Nutrition and Food Research - June 12, 2019 Category: Food Science Authors: Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li Tags: Research Article Source Type: research

Attenuation of Palmitic Acid ‐Induced Lipotoxicity by Chlorogenic Acid Through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protected hepatocytes from FFAs ‐induced lipotoxicity through activation of SIRT1, which reversed the oxidative stress and dysfunction of mitochondrial biogenesis directly.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - June 4, 2019 Category: Food Science Authors: Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li Tags: Research Article Source Type: research

Luteolin Ameliorates Testis Injury and Blood –Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43
ConclusionLuteolin is identified as a novel active ingredient that contributes to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by upregulating Cx43.
Source: Molecular Nutrition and Food Research - April 15, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research