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Total 17 results found since Jan 2013.

MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132953. Online ahead of print.ABSTRACTIn diploid organisms, interactions between alleles determine phenotypic variation. In previous experiments, only MYH1F was found to show both ASE (spatiotemporal allele-specific expression) and TRD (allelic transmission ratio distortion) characteristics in the pectoral muscle by comparing the genome-wide allele lists of hybrid populations (F1) of meat- and egg- type chickens. In addition, MYH1F is a member of the MYH gene family, which plays an important role in skeletal muscle and non-muscle cells of animals, but the speci...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Peng Ren Meiying Chen Jingjing Li Zhongzhen Lin Chaowu Yang Chunlin Yu Donghao Zhang Yiping Liu Source Type: research

MiR-208b Regulates the Conversion of Skeletal Muscle Fiber Types by Inhibiting Mettl8 Expression
In conclusion, our research results show that miR-208b regulates the conversion of different muscle fiber types by inhibiting Mettl8 expression.
Source: Frontiers in Genetics - February 23, 2022 Category: Genetics & Stem Cells Source Type: research

RNA-Seq reveals the potential molecular mechanisms of bovine KLF6 gene in the regulation of adipogenesis
This study aims to investigate the influence of KLF6 (Kruppel Like Factor 6) and associated molecular mechanisms on lipid metabolism in bovine adipocytes. In the current study, KLF6 gene expression was down regulated via siRNA (small interfering RNA) in bovine adipocytes in vitro. Subsequently, adipogenic cells were collected from the culture media after 9 days, and subjected to fluorescent imaging and RNA sequencing. After confirming that KLF6 was down regulated in bovine adipocytes by siRNA, differential gene expression analysis was used to characterize the infuence of KLF6 on gene expression profiles in bovine adipocyte...
Source: International Journal of Biological Macromolecules - December 10, 2021 Category: Biochemistry Authors: Sayed Haidar Abbas Raza Rajwali Khan Gong Cheng Feng Long Sun Bing Ahmed A Easa Nicola M Schreurs Sameer D Pant Wenzhen Zhang Anning Li Linsen Zan Source Type: research

SAP30 Gene Is a Probable Regulator of Muscle Hypertrophy in Chickens
Animals with muscle hypertrophy phenotype are targeted by the broiler industry to increase the meat production and the quality of the final product. Studies characterizing the molecular machinery involved with these processes, such as quantitative trait loci studies, have been carried out identifying several candidate genes related to this trait; however, validation studies of these candidate genes in cell culture is scarce. The aim of this study was to evaluate SAP30 as a candidate gene for muscle development and to validate its function in cell culture in vitro. The SAP30 gene was downregulated in C2C12 muscle cell cultu...
Source: Frontiers in Genetics - September 27, 2021 Category: Genetics & Stem Cells Source Type: research

Suppression of MyoD induces spontaneous adipogenesis in skeletal muscle progenitor cell culture
AbstractThe degree of intramuscular adipose tissue accumulation is one of the factors affecting meat quality. Accumulation of adipocytes is also observed under the pathological condition of skeletal muscle such as muscular dystrophy and sarcopenia. The origin of adipocytes seen in skeletal muscle is mesenchymal progenitor cells that can give rise to both adipocytes and fibroblasts. In the present study, we demonstrated that siRNA-mediated suppression of MyoD expression in rat skeletal muscle progenitor cell culture, which comprises both myogenic satellite cells and mesenchymal progenitor cells, resulted in diminished myotu...
Source: Animal Science Journal - July 7, 2021 Category: Zoology Authors: Keitaro Yamanouchi, Katsuyuki Nakamura, Shiho Takeuchi, Tohru Hosoyama, Takashi Matsuwaki, Masugi Nishihara Tags: RESEARCH ARTICLE Source Type: research

Genes, Vol. 11, Pages 453: AQP3 Facilitates Proliferation and Adipogenic Differentiation of Porcine Intramuscular Adipocytes
In this study, the AQP3 protein of the AQP family was mainly studied in the adipogenic function of intramuscular adipocytes in pigs. Here, we found that AQP3 was increased at both mRNA and protein levels upon adipogenic stimuli in porcine intramuscular adipocytes in vitro. Western blot results showed knockdown of AQP3 by siRNA significantly suppressed the expression of adipogenic genes (PPARγ, aP2, etc.), repressed Akt phosphorylation, as well as reducing lipid accumulation. Furthermore, deletion of AQP3 by siRNA significantly downregulated expression of cell cycle genes (cyclin D, E), and decreased the numbe...
Source: Genes - April 21, 2020 Category: Genetics & Stem Cells Authors: Xiaoyu Wang Jing Yang Ying Yao Xin ’E Shi Gongshe Yang Xiao Li Tags: Article Source Type: research

RXR α cooperates with KLF8 to promote the differentiation of intramuscular preadipocytes in goat.
RXRα cooperates with KLF8 to promote the differentiation of intramuscular preadipocytes in goat. Anim Biotechnol. 2020 Feb 27;:1-11 Authors: Xu Q, Wang Y, Zhang Y, Zhu J, Lin Y Abstract Retinoid X receptor α (RXRα) is thought to be a key regulator in lipid metabolism, glucose metabolism, adipogenic differentiation, gene expression, and inflammatory response. However, it is not clear whether RXRα has any role in intramuscular preadipocyte of goat. In the current investigation, we report that adenovirus overexpression of RXRα promotes lipid accumulation in intramuscular adipocyte and up-regulates t...
Source: Animal Biotechnology - February 26, 2020 Category: Biotechnology Authors: Xu Q, Wang Y, Zhang Y, Zhu J, Lin Y Tags: Anim Biotechnol Source Type: research

RNA-seq reveal role of bovine TORC2 in the regulation of adipogenesis.
In conclusion, our results suggest that TORC2 at least in part regulates lipid metabolism in bovine adipocytes. The results of this study provide a basis for studying the function and molecular mechanism of the TORC2 gene in regulating adipogenesis. PMID: 31893525 [PubMed - as supplied by publisher]
Source: Archives of Biochemistry and Biophysics - December 28, 2019 Category: Biochemistry Authors: Khan R, Abbas Raza SH, Junjvlieke Z, Wang H, Cheng G, Smith SB, Zhongliang J, Li A, Zan L Tags: Arch Biochem Biophys Source Type: research