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Anti-inflammatory effects of novel polygonum multiflorum compound via inhibiting NF- κB/MAPK and upregulating the Nrf2 pathways in LPS-stimulated microglia
Publication date: 9 June 2017 Source:Neuroscience Letters, Volume 651 Author(s): Sun Young Park, Mei Ling Jin, Nam Jun Kang, Geuntae Park, Young-Whan Choi The incorporation of Polygonum multiflorum into the diet can result in anti-aging effects owing to its wide range of biological and pharmaceutical properties. We investigated the anti-neuroinflammatory properties of CRPE56IGIH isolated from P. multiflorum by focusing on its role in the induction of phase II antioxidant enzymes and the modulation of upstream signaling pathways. In microglia, CRPE56IGIH significantly inhibited lipopolysaccharide (LPS)-stimulated nitric ox...
Source: Neuroscience Letters - May 7, 2017 Category: Neuroscience Source Type: research

Anti-neuroinflammatory Effect of Emodin in LPS-Stimulated Microglia: Involvement of AMPK/Nrf2 Activation.
This study examined whether emodin can activate AMPK/Nrf2 signaling and induce the expression of genes targeted by this pathway. In addition, the anti-neuroinflammatory properties of emodin in lipopolysaccharide (LPS)-stimulated microglia were examined. In microglia, the emodin treatment increased the levels of LKB1, CaMKII, and AMPK phosphorylation. Emodin increased the translocation and transactivity of Nrf2 and enhanced the levels of HO-1 and NQO1. In addition, the emodin-mediated expression of HO-1 and NQO1 was attenuated completely by an AMPK inhibitor (compound C). Moreover, emodin decreased dramatically the LPS-indu...
Source: Neurochemical Research - August 18, 2016 Category: Neuroscience Authors: Park SY, Jin ML, Ko MJ, Park G, Choi YW Tags: Neurochem Res Source Type: research

Tetrahydroxystilbene Glucoside Improves TNF-α-Induced Endothelial Dysfunction: Involvement of TGFβ/Smad Pathway and Inhibition of Vimentin Expression.
Abstract Endothelial dysfunction plays an important role in the pathogenesis of atherogenesis. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component of the rhizome extract from Polygonum multiflorum (PM), exhibits significant anti-atherosclerotic activity. Here, we used human umbilical vein endothelial cells (HUVECs) induced by tumor necrosis factor-α (TNF-α) in vitro to investigate the cytoprotective effects of TSG on TNF-α-induced endothelial injury and the related mechanisms. Pretreatment with 50 and 100 μM TSG markedly attenuated TNF-α-induced loss of cell viability and release of la...
Source: The American Journal of Chinese Medicine - January 8, 2015 Category: Complementary Medicine Authors: Yao W, Gu C, Shao H, Meng G, Wang H, Jing X, Zhang W Tags: Am J Chin Med Source Type: research