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Total 77 results found since Jan 2013.
A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy
In this study, we synthesized a hyaluronan-based ROS-sensitive polymer which was expected to release loaded chemical drugs in inflammatory environment and further developed a stable and nontoxic co-delivery nanosystem of siRNA targeting autophagy suppressive gene and chemotherapeutic agents. The in vitro transfection study of this nanosystem revealed improved intracellular accumulation of siRNA and excellent gene silencing efficacy comparable to that of conventional cationic liposome. Moreover, the mRNA expression of inflammatory cytokines was remarkably decreased by our nanosystem. Considering its biocompatibility, transf...
Source: Carbohydrate Polymers - May 3, 2018 Category: Biomedical Science Source Type: research
Specifically-sized hyaluronan (35 kDa) prevents ethanol-induced disruption of epithelial tight junctions through a Layilin-dependent mechanism in Caco-2 cells.
CONCLUSION: Taken together, these data indicate that HA35 interacts with Layilin on intestinal epithelial cells and maintains intestinal tight junction integrity during short-term ethanol exposure. This article is protected by copyright. All rights reserved.
PMID: 31237689 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - June 24, 2019 Category: Addiction Authors: Bellos DA, Sharma D, McMullen MR, Wat J, Saikia P, de la Motte CA, Nagy LE Tags: Alcohol Clin Exp Res Source Type: research
Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation
ConclusionCollectively, these results show that targeting endothelial TXNIP in metabolic disorders is essential to maintaining endothelial function, vascular function and improving ischemia-induced revascularisation, making TXNIP a potential therapeutic target for therapy of vascular complications related to metabolic disorders.
Source: Angiogenesis - January 2, 2020 Category: Molecular Biology Source Type: research
RNA-Seq reveals the potential molecular mechanisms of bovine KLF6 gene in the regulation of adipogenesis
This study aims to investigate the influence of KLF6 (Kruppel Like Factor 6) and associated molecular mechanisms on lipid metabolism in bovine adipocytes. In the current study, KLF6 gene expression was down regulated via siRNA (small interfering RNA) in bovine adipocytes in vitro. Subsequently, adipogenic cells were collected from the culture media after 9 days, and subjected to fluorescent imaging and RNA sequencing. After confirming that KLF6 was down regulated in bovine adipocytes by siRNA, differential gene expression analysis was used to characterize the infuence of KLF6 on gene expression profiles in bovine adipocyte...
Source: International Journal of Biological Macromolecules - December 10, 2021 Category: Biochemistry Authors: Sayed Haidar Abbas Raza Rajwali Khan Gong Cheng Feng Long Sun Bing Ahmed A Easa Nicola M Schreurs Sameer D Pant Wenzhen Zhang Anning Li Linsen Zan Source Type: research
CLEC4A and CLEC12B C-type lectin receptors mediate interactions with < em > Pneumocystis < /em > cell wall components
Conclusion. The data presented here provide new members of the CLRs family recognizing Pneumocystis. Future studies using CLEC4A and/or CLEC12B deficient mice in the PCP mouse model should provide further insights into the host immunological response to Pneumocystis.PMID:37294293 | DOI:10.1099/jmm.0.001714
Source: Journal of Medical Microbiology - June 9, 2023 Category: Microbiology Authors: Theodore J Kottom Eva M Carmona Kyle Schaefbauer Andrew H Limper Source Type: research
Abstract 1199: Systems-based approach identifies altered carbohydrate metabolism as a predictor of a malignant phenotype in ovarian cancer
Conclusions: Here, we present a novel systems-based approach using altered metabolites and genes to predict a malignant phenotype specific to HGSOC patients. Altered metabolism, coupled with genomic analyses, identified the most interconnected gene-biochemical networks that will lead to novel biomarkers and therapeutic targets.Citation Format: Rebecca A. Previs, Tyler J. Moss, Behrouz Zand, Rajesha Rupaimoole, Heather J. Dalton, Jean M. Hansen, Guillermo Armaiz-Pena, Susan Lutgendorf, Robert L. Coleman, Pratip Bhattacharya, Prahlad Ram, Anil K. Sood. Systems-based approach identifies altered carbohydrate metabolism as a pr...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Previs, R. A., Moss, T. J., Zand, B., Rupaimoole, R., Dalton, H. J., Hansen, J. M., Armaiz-Pena, G., Lutgendorf, S., Coleman, R. L., Bhattacharya, P., Ram, P., Sood, A. K. Tags: Molecular and Cellular Biology Source Type: research
Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer
Publication date: Available online 8 July 2018Source: International Journal of PharmaceuticsAuthor(s): Shubhangi Mahajan, Abhimanyu Patharkar, Kaushik Kuche, Rahul Maheshwari, Pran Kishore Deb, Kiran Kalia, Rakesh K. TekadeAbstractIn recent time, carbon nanotubes (CNTs) have gained vital importance for pharmaceutical formulation scientist for delivering drugs and genes, owing to their excellent surface properties. For example, their aspect ratio is thought to be responsible for their excellent cell penetration aptitude; anisotropic conductivity/semi-conductivity along their axis is ideal for integration with nervous and mu...
Source: International Journal of Pharmaceutics - July 8, 2018 Category: Drugs & Pharmacology Source Type: research
