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Intestinal enteroendocrine cells rely on ryanodine and IP < sub > 3 < /sub > calcium store receptors for mechanotransduction
This study has found that the signal amplification involves calcium induced calcium release (CICR) mechanisms activated through intracellular stores receptors, RyR3 and IP3Rs. Activation of these receptors leads to large and sustained increase in Ca2+ that results in the release of serotonin (5-HT) that plays an important role in many local and systemic processes. This article is protected by copyright. All rights reserved.PMID:36428286 | DOI:10.1113/JP283383
Source: The Journal of Physiology - November 26, 2022 Category: Physiology Authors: Kaitlyn R Knutson Sara T Whiteman Constanza Alcaino Arnaldo Mercado-Perez Isabelle Finholm Hannah K Serlin Shreya S Bellampalli David R Linden Gianrico Farrugia Arthur Beyder Source Type: research

The mechanosensitive Piezo1 channels contribute to the arterial medial calcification
Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as has the role of intracellular Ca2+ in regulating SMC function. Increased intracellular calcium concentration ([Ca2+]i) in vascular SMC has been proposed to stimulate VC. However, the contribution of the non-selective Piezo1 mechanosensitive cation channels to the elevation of [Ca2+]i, and consequently to the process of VC has never been examined. In this work the essential contribution of Piezo1 channels to arterial medial cal...
Source: Frontiers in Physiology - November 10, 2022 Category: Physiology Source Type: research

Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research

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